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Ldah lipid droplet associated hydrolase [ Mus musculus (house mouse) ]

Gene ID: 68832, updated on 11-Apr-2024

Summary

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Official Symbol
Ldahprovided by MGI
Official Full Name
lipid droplet associated hydrolaseprovided by MGI
Primary source
MGI:MGI:1916082
See related
Ensembl:ENSMUSG00000037669 AllianceGenome:MGI:1916082
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mLDAH; 1110057K04Rik
Summary
Enables lipase activity. Predicted to be involved in lipid storage. Located in lipid droplet. Is expressed in brain; brown fat; colon; small intestine; and testis. Orthologous to human LDAH (lipid droplet associated hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 10.8), large intestine adult (RPKM 7.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 A1.1; 12 3.85 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (8258095..8350811)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (8208095..8300811)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53751 Neighboring gene apolipoprotein B Neighboring gene STARR-seq mESC enhancer starr_31489 Neighboring gene predicted gene, 33037 Neighboring gene STARR-seq mESC enhancer starr_31490 Neighboring gene STARR-seq mESC enhancer starr_31491 Neighboring gene STARR-seq mESC enhancer starr_31492 Neighboring gene STARR-positive B cell enhancer ABC_E8885 Neighboring gene STARR-seq mESC enhancer starr_31493 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:8320448-8320557 Neighboring gene STARR-positive B cell enhancer mm9_chr12:8333629-8333930 Neighboring gene growth differentiation factor 7 Neighboring gene HCLS1 binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_31498 Neighboring gene predicted gene, 48071 Neighboring gene predicted gene, 33134

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism. Kory N, et al. J Lipid Res, 2017 Jan. PMID 27836991, Free PMC Article
  2. Loss of LDAH associated with prostate cancer and hearing loss. Currall BB, et al. Hum Mol Genet, 2018 Dec 15. PMID 30169630, Free PMC Article
  3. Novel lipid droplet-associated serine hydrolase regulates macrophage cholesterol mobilization. Goo YH, et al. Arterioscler Thromb Vasc Biol, 2014 Feb. PMID 24357060, Free PMC Article
  4. The evolutionarily conserved protein CG9186 is associated with lipid droplets, required for their positioning and for fat storage. Thiel K, et al. J Cell Sci, 2013 May 15. PMID 23525007, Free PMC Article
  5. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We then amassed convergent genomic evidence showing population level associations between LDAHexpression and occurrence of prostate cancer . We further identified loss of LDAH in both tissues and cell lines derived from human prostate cancer, and generated Ldah-/- mouse model, which recapitulated many of the clinical findings in DGAP056.
    Title: Loss of LDAH associated with prostate cancer and hearing loss.
  2. Our data suggest that LDAH is not a major cholesterol ester hydrolase, and an alternative metabolic function may be responsible for its possible effect on development of prostate cancer.
    Title: Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism.
  3. The data identify LDAH a candidate target to promote reverse cholesterol transport from atherosclerotic lesions.
    Title: Novel lipid droplet-associated serine hydrolase regulates macrophage cholesterol mobilization.
  4. this study identified a novel lipid droplets -associated protein family, represented by the Drosophila protein CG9186 and its murine homolog MGI:1916082.
    Title: The evolutionarily conserved protein CG9186 is associated with lipid droplets, required for their positioning and for fat storage.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables sterol esterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in foam cell differentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in lipid storage IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lipid droplet-associated hydrolase
Names
LD-associated hydrolase
UPF0554 protein C2orf43 homolog
lipid droplet-associated serine hydrolase
NP_001161239.1
NP_001161240.1
NP_001351189.1
NP_001351190.1
NP_765989.3
XP_006515264.2
XP_006515265.2
XP_030102758.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167767.2 → NP_001161239.1  lipid droplet-associated hydrolase isoform 2

    See identical proteins and their annotated locations for NP_001161239.1

    Status: VALIDATED

    Source sequence(s)
    AC122860, AI746795, BC057311
    Consensus CDS
    CCDS49023.1
    UniProtKB/TrEMBL
    A0A0F6AIX6
    Related
    ENSMUSP00000129424.2, ENSMUST00000169104.3
    Conserved Domains (1) summary
    cl21494
    Location:43 → 236
    Abhydrolase; alpha/beta hydrolases

  2. NM_001167768.2 → NP_001161240.1  lipid droplet-associated hydrolase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK162914, AW049235, BB168827, BB626438
    Consensus CDS
    CCDS88307.1
    UniProtKB/Swiss-Prot
    Q3TRE7, Q5RL52, Q6PG15, Q8BVA5, Q8BVV0
    UniProtKB/TrEMBL
    A0A1W2P7C8
    Related
    ENSMUSP00000151612.2, ENSMUST00000218086.2
    Conserved Domains (1) summary
    pfam10230
    Location:43 → 266
    DUF2305; uncharacterized conserved protein (DUF2305)

  3. NM_001364260.1 → NP_001351189.1  lipid droplet-associated hydrolase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122860
    Consensus CDS
    CCDS25798.1
    UniProtKB/Swiss-Prot
    Q3TRE7, Q5RL52, Q6PG15, Q8BVA5, Q8BVV0
    UniProtKB/TrEMBL
    A0A0F6AIX5
    Conserved Domains (1) summary
    pfam10230
    Location:43 → 304
    LIDHydrolase; Lipid-droplet associated hydrolase

  4. NM_001364261.1 → NP_001351190.1  lipid droplet-associated hydrolase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122860
    Consensus CDS
    CCDS25798.1
    UniProtKB/Swiss-Prot
    Q3TRE7, Q5RL52, Q6PG15, Q8BVA5, Q8BVV0
    UniProtKB/TrEMBL
    A0A0F6AIX5
    Conserved Domains (1) summary
    pfam10230
    Location:43 → 304
    LIDHydrolase; Lipid-droplet associated hydrolase

  5. NM_172401.5 → NP_765989.3  lipid droplet-associated hydrolase isoform 1

    See identical proteins and their annotated locations for NP_765989.3

    Status: VALIDATED

    Source sequence(s)
    AC122860
    Consensus CDS
    CCDS25798.1
    UniProtKB/Swiss-Prot
    Q3TRE7, Q5RL52, Q6PG15, Q8BVA5, Q8BVV0
    UniProtKB/TrEMBL
    A0A0F6AIX5
    Related
    ENSMUSP00000042285.6, ENSMUST00000037383.13
    Conserved Domains (1) summary
    pfam10230
    Location:43 → 304
    LIDHydrolase; Lipid-droplet associated hydrolase

RNA

  1. NR_157106.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122860

  2. NR_157107.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122860, AK076460

  3. NR_157108.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122860, AK086717
    Related
    ENSMUST00000219043.2

  4. NR_157109.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122860, AK162850
    Related
    ENSMUST00000219058.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    8258095..8350811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246898.2 → XP_030102758.1  lipid droplet-associated hydrolase isoform X1

    UniProtKB/Swiss-Prot
    Q3TRE7, Q5RL52, Q6PG15, Q8BVA5, Q8BVV0
    Conserved Domains (1) summary
    pfam10230
    Location:48 → 256
    LIDHydrolase; Lipid-droplet associated hydrolase

  2. XM_006515202.3 → XP_006515265.2  lipid droplet-associated hydrolase isoform X2

    UniProtKB/Swiss-Prot
    Q3TRE7, Q5RL52, Q6PG15, Q8BVA5, Q8BVV0
    Conserved Domains (1) summary
    pfam10230
    Location:43 → 263
    LIDHydrolase; Lipid-droplet associated hydrolase

  3. XM_006515201.5 → XP_006515264.2  lipid droplet-associated hydrolase isoform X1

    UniProtKB/Swiss-Prot
    Q3TRE7, Q5RL52, Q6PG15, Q8BVA5, Q8BVV0
    Conserved Domains (1) summary
    pfam10230
    Location:48 → 256
    LIDHydrolase; Lipid-droplet associated hydrolase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVA5.1 GenPept UniProtKB/Swiss-Prot:Q8BVA5

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