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Zfand2b zinc finger, AN1 type domain 2B [ Mus musculus (house mouse) ]

Gene ID: 68818, updated on 5-Mar-2024

Summary

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Official Symbol
Zfand2bprovided by MGI
Official Full Name
zinc finger, AN1 type domain 2Bprovided by MGI
Primary source
MGI:MGI:1916068
See related
Ensembl:ENSMUSG00000026197 AllianceGenome:MGI:1916068
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110060O18Rik
Summary
Enables K48-linked polyubiquitin modification-dependent protein binding activity and ubiquitin binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein targeting to ER; and regulation of insulin-like growth factor receptor signaling pathway. Located in endoplasmic reticulum. Is anchored component of membrane. Part of proteasome complex. Orthologous to human ZFAND2B (zinc finger AN1-type containing 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 27.4), large intestine adult (RPKM 24.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C4; 1 38.61 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75145290..75148270)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75168646..75171626)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cyclin Pas1/PHO80 domain containing 1 Neighboring gene reticulophagy regulator family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E1550 Neighboring gene ATP-binding cassette, sub-family B member 6 Neighboring gene STARR-positive B cell enhancer ABC_E8982 Neighboring gene autophagy related 9A Neighboring gene STARR-positive B cell enhancer ABC_E321

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Selective Binding of AIRAPL Tandem UIMs to Lys48-Linked Tri-Ubiquitin Chains. Rahighi S, et al. Structure, 2016 Mar 1. PMID 26876100, Free PMC Article
  2. Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex. Glinka T, et al. Biochem J, 2014 Jan 15. PMID 24160817
  3. Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans. Yun C, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18467495, Free PMC Article
  4. Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling. Osorio FG, et al. Nat Med, 2016 Jan. PMID 26692333
  5. Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. McLelland GL, et al. Elife, 2018 Apr 20. PMID 29676259, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K48-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables K48-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane, translocation ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to ER IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to ER ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
AN1-type zinc finger protein 2B
Names
AIRAP-like protein
arsenite-inducible RNA-associated protein-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159905.1 → NP_001153377.1  AN1-type zinc finger protein 2B

    See identical proteins and their annotated locations for NP_001153377.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three transcripts encode the same protein.
    Source sequence(s)
    AK151430, BX633014, CX217579
    Consensus CDS
    CCDS15064.1
    UniProtKB/Swiss-Prot
    Q91X58, Q9D0W4
    UniProtKB/TrEMBL
    E0CY18
    Related
    ENSMUSP00000125086.2, ENSMUST00000160439.8
    Conserved Domains (2) summary
    pfam01428
    Location:100 → 136
    zf-AN1; AN1-like Zinc finger
    pfam02809
    Location:197 → 213
    UIM; Ubiquitin interaction motif

  2. NM_001159906.1 → NP_001153378.1  AN1-type zinc finger protein 2B

    See identical proteins and their annotated locations for NP_001153378.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three transcripts encode the same protein.
    Source sequence(s)
    AK151430, BX633014, BY197482
    Consensus CDS
    CCDS15064.1
    UniProtKB/Swiss-Prot
    Q91X58, Q9D0W4
    UniProtKB/TrEMBL
    E0CY18
    Related
    ENSMUSP00000124552.2, ENSMUST00000162768.8
    Conserved Domains (2) summary
    pfam01428
    Location:100 → 136
    zf-AN1; AN1-like Zinc finger
    pfam02809
    Location:197 → 213
    UIM; Ubiquitin interaction motif

  3. NM_026846.3 → NP_081122.2  AN1-type zinc finger protein 2B

    See identical proteins and their annotated locations for NP_081122.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three transcripts encode the same protein.
    Source sequence(s)
    AK151430, BX633014
    Consensus CDS
    CCDS15064.1
    UniProtKB/Swiss-Prot
    Q91X58, Q9D0W4
    UniProtKB/TrEMBL
    E0CY18
    Related
    ENSMUSP00000027394.6, ENSMUST00000027394.12
    Conserved Domains (2) summary
    pfam01428
    Location:100 → 136
    zf-AN1; AN1-like Zinc finger
    pfam02809
    Location:197 → 213
    UIM; Ubiquitin interaction motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    75145290..75148270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91X58.1 GenPept UniProtKB/Swiss-Prot:Q91X58

Gene LinkOut

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