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Btbd10 BTB domain containing 10 [ Mus musculus (house mouse) ]

Gene ID: 68815, updated on 5-Mar-2024

Summary

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Official Symbol
Btbd10provided by MGI
Official Full Name
BTB domain containing 10provided by MGI
Primary source
MGI:MGI:1916065
See related
Ensembl:ENSMUSG00000038187 AllianceGenome:MGI:1916065
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gmrp1; 1110056N09Rik
Summary
Involved in negative regulation of neuron death and positive regulation of phosphorylation. Located in cytoplasm. Orthologous to human BTBD10 (BTB domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 11.6), CNS E18 (RPKM 7.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F1; 7 59.18 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (112914838..112970734, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (113315631..113371527, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930543E12 gene Neighboring gene STARR-seq mESC enhancer starr_19892 Neighboring gene STARR-seq mESC enhancer starr_19896 Neighboring gene STARR-seq mESC enhancer starr_19898 Neighboring gene STARR-positive B cell enhancer ABC_E157 Neighboring gene basic helix-loop-helix ARNT like 1 Neighboring gene STARR-seq mESC enhancer starr_19903 Neighboring gene STARR-seq mESC enhancer starr_19904 Neighboring gene predicted gene, 33721 Neighboring gene STARR-positive B cell enhancer ABC_E11364 Neighboring gene STARR-positive B cell enhancer ABC_E3744 Neighboring gene STARR-positive B cell enhancer ABC_E9297 Neighboring gene parathyroid hormone Neighboring gene STARR-seq mESC enhancer starr_19909 Neighboring gene BCL2-associated transcription factor 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. Nawa M, et al. Cell Signal, 2008 Mar. PMID 18160256
  2. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BTBD10 appears to behave as a suppressor of cell death including neuronal cell death related to amyotrophic lateral sclerosis and an enhancer of cell growth via its positive regulation of Akt phosphorylation.
    Title: A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing protein 10
Names
BTB (POZ) domain containing 10
K+ channel tetramerization protein
glucose metabolism-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133700.3 → NP_598461.1  BTB/POZ domain-containing protein 10

    See identical proteins and their annotated locations for NP_598461.1

    Status: VALIDATED

    Source sequence(s)
    AC156605, AC156987
    Consensus CDS
    CCDS21755.1
    UniProtKB/Swiss-Prot
    Q80X66
    Related
    ENSMUSP00000048530.8, ENSMUST00000047091.14
    Conserved Domains (1) summary
    cd18385
    Location:165 → 274
    BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    112914838..112970734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508162.3 → XP_006508225.1  BTB/POZ domain-containing protein 10 isoform X3

    See identical proteins and their annotated locations for XP_006508225.1

    UniProtKB/TrEMBL
    E9Q6L8
    Related
    ENSMUSP00000113632.2, ENSMUST00000119278.8
    Conserved Domains (1) summary
    cd18385
    Location:117 → 226
    BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

  2. XM_006508160.3 → XP_006508223.1  BTB/POZ domain-containing protein 10 isoform X2

    See identical proteins and their annotated locations for XP_006508223.1

    UniProtKB/Swiss-Prot
    Q80X66
    Conserved Domains (1) summary
    cd18385
    Location:165 → 274
    BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

  3. XM_006508161.3 → XP_006508224.1  BTB/POZ domain-containing protein 10 isoform X3

    See identical proteins and their annotated locations for XP_006508224.1

    UniProtKB/TrEMBL
    E9Q6L8
    Conserved Domains (1) summary
    cd18385
    Location:117 → 226
    BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

  4. XM_006508163.3 → XP_006508226.1  BTB/POZ domain-containing protein 10 isoform X3

    See identical proteins and their annotated locations for XP_006508226.1

    UniProtKB/TrEMBL
    E9Q6L8
    Conserved Domains (1) summary
    cd18385
    Location:117 → 226
    BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

  5. XM_011241890.3 → XP_011240192.1  BTB/POZ domain-containing protein 10 isoform X2

    See identical proteins and their annotated locations for XP_011240192.1

    UniProtKB/Swiss-Prot
    Q80X66
    Conserved Domains (1) summary
    cd18385
    Location:165 → 274
    BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

  6. XM_006508159.5 → XP_006508222.1  BTB/POZ domain-containing protein 10 isoform X1

    UniProtKB/TrEMBL
    E9Q6Y9
    Related
    ENSMUSP00000113496.2, ENSMUST00000117577.8
    Conserved Domains (1) summary
    cd18385
    Location:173 → 282
    BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80X66.1 GenPept UniProtKB/Swiss-Prot:Q80X66

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