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Tmem214 transmembrane protein 214 [ Mus musculus (house mouse) ]

Gene ID: 68796, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem214provided by MGI
Official Full Name
transmembrane protein 214provided by MGI
Primary source
MGI:MGI:1916046
See related
Ensembl:ENSMUSG00000038828 AllianceGenome:MGI:1916046
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110039B18Rik; 4921530J21Rik
Summary
Predicted to act upstream of or within apoptotic process. Predicted to be located in cytoplasmic microtubule and cytosol. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in axial skeleton; chondrocranium; otic capsule; and rib. Orthologous to human TMEM214 (transmembrane protein 214). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 69.9), testis adult (RPKM 47.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem214 in Genome Data Viewer
Location:
5 B1; 5 16.9 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31026923..31034813)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30869579..30877469)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene dihydropyrimidinase-like 5 Neighboring gene STARR-seq mESC enhancer starr_12761 Neighboring gene predicted gene, 46907 Neighboring gene microtubule-associated protein, RP/EB family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E10311 Neighboring gene STARR-seq mESC enhancer starr_12763 Neighboring gene nuclear encoded tRNA alanine 15 (anticodon AGC) Neighboring gene nuclear encoded tRNA tyrosine 9 (anticodon GTA) Neighboring gene predicted gene, 35795 Neighboring gene ATP/GTP binding protein-like 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA-splicing factors during adipogenesis. Mugabo Y, et al. J Biol Chem, 2018 May 4. PMID 29530978, Free PMC Article
  2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20254

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 214

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144525.4 → NP_653108.2  transmembrane protein 214

    See identical proteins and their annotated locations for NP_653108.2

    Status: VALIDATED

    Source sequence(s)
    AC109606, AK034883
    Consensus CDS
    CCDS19164.1
    UniProtKB/Swiss-Prot
    Q3TLH3, Q3UPX9, Q78HK3, Q8BM55, Q8R0D5, Q8R237, Q8VC05
    UniProtKB/TrEMBL
    D3Z6S1
    Related
    ENSMUSP00000144615.2, ENSMUST00000201203.4
    Conserved Domains (1) summary
    pfam10151
    Location:217 → 683
    DUF2359; uncharacterized conserved protein (DUF2359)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31026923..31034813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165466.1 → XP_036021359.1  transmembrane protein 214 isoform X1

    Related
    ENSMUST00000202008.2
    Conserved Domains (1) summary
    pfam10151
    Location:1 → 378
    TMEM214; C-terminal, caspase 4 activator
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BM55.1 GenPept UniProtKB/Swiss-Prot:Q8BM55

Gene LinkOut

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