Fendrr Foxf1 adjacent non-coding developmental regulatory RNA [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fendrrprovided by MGI
Official Full Name: Foxf1 adjacent non-coding developmental regulatory RNAprovided by MGI
Primary source: MGI:MGI:1916040
See related: Ensembl:ENSMUSG00000097336 AllianceGenome:MGI:1916040
Gene type: ncRNA
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LL66; lincFoxf1; linc-Foxf1a; 1110050K14Rik
Summary: This gene encodes a spliced long non-coding RNA transcribed from a bidirectional promoter shared with Foxf1 on the opposite strand. The encoded transcript is essential for normal development of the heart and body wall. It is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It plays a role in cell fate determination in tissues derived from the lateral plate mesoderm. Knockout models reveal loss of this gene is lethal in mice. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2014]
Expression: Biased expression in lung adult (RPKM 90.0), bladder adult (RPKM 43.2) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 70.28 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (121781621..121809849, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (121054882..121083110, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fendrr synergizes with Wnt signalling to regulate fibrosis related genes during lung development via its RNA:dsDNA triplex element.
Title: Fendrr synergizes with Wnt signalling to regulate fibrosis related genes during lung development via its RNA:dsDNA triplex element.
LncRNA Fendrr: involvement in the protective role of nucleolin against H2O2-induced injury in cardiomyocytes.
Title: LncRNA Fendrr: involvement in the protective role of nucleolin against H(2)O(2)-induced injury in cardiomyocytes.
LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation.
Title: LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation.
LncRNA FENDRR promotes apoptosis of Leydig cells in late-onset hypogonadism by facilitating the degradation of Nrf2.
Title: LncRNA FENDRR promotes apoptosis of Leydig cells in late-onset hypogonadism by facilitating the degradation of Nrf2.
Long Non-coding RNA FENDRR Modulates Autophagy Through Epigenetic Suppression of ATG7 via Binding PRC2 in Acute Pancreatitis.
Title: Long Non-coding RNA FENDRR Modulates Autophagy Through Epigenetic Suppression of ATG7 via Binding PRC2 in Acute Pancreatitis.
LncRNA-Fendrr protects against the ubiquitination and degradation of NLRC4 protein through HERC2 to regulate the pyroptosis of microglia.
Title: LncRNA-Fendrr protects against the ubiquitination and degradation of NLRC4 protein through HERC2 to regulate the pyroptosis of microglia.
Long non-coding RNA FENDRR regulates IFNgamma-induced M1 phenotype in macrophages.
Title: Long non-coding RNA FENDRR regulates IFNγ-induced M1 phenotype in macrophages.
Fendrr involves in the pathogenesis of cardiac fibrosis via regulating miR-106b/SMAD3 axis.
Title: Fendrr involves in the pathogenesis of cardiac fibrosis via regulating miR-106b/SMAD3 axis.
FENDRR could promote the apoptosis of human brain microvascular endothelial cells via miR-126 regulating VEGFA in hypertensive intracerebral hemorrhage
Title: LncRNA-FENDRR mediates VEGFA to promote the apoptosis of brain microvascular endothelial cells via regulating miR-126 in mice with hypertensive intracerebral hemorrhage.
The lncRNA Fendrr is transiently expressed in lateral mesoderm of mid-gestational mouse embryos and interacts with PRC2 and TrxG/Mll complexes in vivo. Gene targeting revealed that loss of Fendrr results in impaired differentiation of tissues derived from lateral mesoderm, the heart and the body wall, ultimately leading to embryonic death.
Title: The long non-coding RNA Fendrr links epigenetic control mechanisms to gene regulatory networks in mammalian embryogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within respiratory system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IC Inferred by Curator more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_045471.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an internal exon and uses an alternate 3' structure, resulting in a shorter transcript compared to variant 1.

Source sequence(s)

AC124170, AK087264, JQ973641

Related

ENSMUST00000181530.8
NR_130109.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript.

Source sequence(s)

AC124170, AK004221, JQ973641

Related

ENSMUST00000182264.2