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Gucd1 guanylyl cyclase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 68778, updated on 5-Mar-2024

Summary

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Official Symbol
Gucd1provided by MGI
Official Full Name
guanylyl cyclase domain containing 1provided by MGI
Primary source
MGI:MGI:1916028
See related
Ensembl:ENSMUSG00000033416 AllianceGenome:MGI:1916028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110038D17Rik
Summary
Is expressed in liver lobe and metanephros. Orthologous to human GUCD1 (guanylyl cyclase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine adult (RPKM 37.8), duodenum adult (RPKM 36.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gucd1 in Genome Data Viewer
Location:
10 C1; 10 38.53 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75342648..75353806, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75506814..75517972, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ureidopropionase, beta Neighboring gene STARR-positive B cell enhancer ABC_E9345 Neighboring gene RIKEN cDNA 4933407G14 gene Neighboring gene STARR-positive B cell enhancer ABC_E6873 Neighboring gene STARR-positive B cell enhancer ABC_E9793 Neighboring gene small nuclear ribonucleoprotein D3 Neighboring gene predicted gene, 35061 Neighboring gene leucine rich repeat containing 75B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice. Endoh-Yamagami S, et al. Dev Biol, 2010 Apr 1. PMID 20096683
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
protein GUCD1
Names
guanylyl cyclase domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347201.1 → NP_001334130.1  protein GUCD1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC144461, AK034509, BE952992
    Consensus CDS
    CCDS83713.1
    UniProtKB/TrEMBL
    A0A0R4J1X3, Q05CJ4
    Related
    ENSMUSP00000113976.2, ENSMUST00000118936.8
    Conserved Domains (1) summary
    pfam09778
    Location:1 → 196
    Guanylate_cyc_2; Guanylylate cyclase

  2. NM_175133.2 → NP_780342.1  protein GUCD1 isoform 1

    See identical proteins and their annotated locations for NP_780342.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC144461, AK034509, AK040832, BE952992
    Consensus CDS
    CCDS35936.1
    UniProtKB/Swiss-Prot
    Q147V8, Q3TZX7, Q80XN8, Q8BLZ0, Q8BZI6
    UniProtKB/TrEMBL
    A0A0R4J1X3
    Related
    ENSMUSP00000043000.8, ENSMUST00000039796.14
    Conserved Domains (1) summary
    pfam09778
    Location:22 → 235
    Guanylate_cyc_2; Guanylylate cyclase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    75342648..75353806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514034.4 → XP_006514097.2  protein GUCD1 isoform X1

    UniProtKB/TrEMBL
    A0A0R4J1X3, Q05CJ4
    Conserved Domains (1) summary
    pfam09778
    Location:1 → 196
    Guanylate_cyc_2; Guanylylate cyclase

  2. XM_030245248.2 → XP_030101108.1  protein GUCD1 isoform X2

    Conserved Domains (1) summary
    pfam09778
    Location:1 → 161
    Guanylate_cyc_2; Guanylylate cyclase

  3. XM_036155978.1 → XP_036011871.1  protein GUCD1 isoform X2

    Conserved Domains (1) summary
    pfam09778
    Location:1 → 161
    Guanylate_cyc_2; Guanylylate cyclase

  4. XM_030245249.2 → XP_030101109.1  protein GUCD1 isoform X2

    Conserved Domains (1) summary
    pfam09778
    Location:1 → 161
    Guanylate_cyc_2; Guanylylate cyclase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZI6.2 GenPept UniProtKB/Swiss-Prot:Q8BZI6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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