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Acss1 acyl-CoA synthetase short-chain family member 1 [ Mus musculus (house mouse) ]

Gene ID: 68738, updated on 5-Mar-2024

Summary

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Official Symbol
Acss1provided by MGI
Official Full Name
acyl-CoA synthetase short-chain family member 1provided by MGI
Primary source
MGI:MGI:1915988
See related
Ensembl:ENSMUSG00000027452 AllianceGenome:MGI:1915988
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acas2; Acas2l; AceCS2; 1110032O15Rik
Summary
Enables acetate-CoA ligase activity and propionate-CoA ligase activity. Acts upstream of or within acetyl-CoA biosynthetic process. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ACSS1 (acyl-CoA synthetase short chain family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 106.8), heart adult (RPKM 84.4) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 G3; 2 74.74 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (150460031..150510160, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (150618111..150668240, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:150404413-150404596 Neighboring gene cystatin F (leukocystatin) Neighboring gene adipocyte plasma membrane associated protein Neighboring gene STARR-positive B cell enhancer ABC_E2647 Neighboring gene predicted gene, 52532 Neighboring gene STARR-seq mESC enhancer starr_06012 Neighboring gene RIKEN cDNA E130215H24 gene Neighboring gene STARR-positive B cell enhancer ABC_E4509 Neighboring gene STARR-seq mESC enhancer starr_06014 Neighboring gene visual system homeobox 1 Neighboring gene STARR-positive B cell enhancer ABC_E2053 Neighboring gene STARR-positive B cell enhancer ABC_E1604 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. Sakakibara I, et al. Cell Metab, 2009 Feb. PMID 19187775
  2. A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2. Yamamoto J, et al. J Biol Chem, 2004 Apr 23. PMID 14960588
  3. Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1. Sahar S, et al. J Biol Chem, 2014 Feb 28. PMID 24425865, Free PMC Article
  4. Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate. Fujino T, et al. J Biol Chem, 2001 Apr 6. PMID 11150295
  5. Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Hallows WC, et al. Proc Natl Acad Sci U S A, 2006 Jul 5. PMID 16790548, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models.
    Title: Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models.
  2. Activation of acetyl-CoA synthetase 2 mediates kidney injury in diabetic nephropathy.
    Title: Activation of acetyl-CoA synthetase 2 mediates kidney injury in diabetic nephropathy.
  3. acetylation of AceCS1 is cyclic and that its rhythmicity requires a functional circadian clock and the NAD(+)-dependent deacetylase SIRT1.
    Title: Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1.
  4. Findings demonstrate that activation of acetate by AceCS2 plays a pivotal role in thermogenesis, especially under low-glucose or ketogenic conditions, and is crucially required for survival.
    Title: Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.
  5. together with the trans-activation of the AceCS2 promoter, it is suggested that fasting-induced AceCS2 expression is largely contributed by KLF15
    Title: A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AMP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables propionate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in acetyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acetyl-CoA biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in acetyl-CoA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in acetyl-CoA biosynthetic process from acetate IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in propionate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
acetyl-coenzyme A synthetase 2-like, mitochondrial
Names
acetate--CoA ligase 2
acetyl-CoA synthetase 2
propionate--CoA ligase
NP_542142.1
XP_036018418.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080575.2 → NP_542142.1  acetyl-coenzyme A synthetase 2-like, mitochondrial precursor

    See identical proteins and their annotated locations for NP_542142.1

    Status: VALIDATED

    Source sequence(s)
    AK146568, AK173275
    Consensus CDS
    CCDS16859.1
    UniProtKB/Swiss-Prot
    Q8K0M6, Q99NB1
    UniProtKB/TrEMBL
    Q3TZ45, Q3UJ89, Q69Z91
    Related
    ENSMUSP00000028944.4, ENSMUST00000028944.4
    Conserved Domains (1) summary
    TIGR02188
    Location:45 → 670
    Ac_CoA_lig_AcsA; acetate--CoA ligase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    150460031..150510160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162525.1 → XP_036018418.1  acetyl-coenzyme A synthetase 2-like, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl17068
    Location:46 → 355
    AFD_class_I; Adenylate forming domain, Class I superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99NB1.1 GenPept UniProtKB/Swiss-Prot:Q99NB1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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