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Angel1 angel homolog 1 [ Mus musculus (house mouse) ]

Gene ID: 68737, updated on 5-Mar-2024

Summary

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Official Symbol
Angel1provided by MGI
Official Full Name
angel homolog 1provided by MGI
Primary source
MGI:MGI:1915987
See related
Ensembl:ENSMUSG00000021257 AllianceGenome:MGI:1915987
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0759; 1110030H02Rik
Summary
Predicted to enable 3'-5'-exoribonuclease activity; eukaryotic initiation factor 4E binding activity; and protein domain specific binding activity. Predicted to be located in several cellular components, including cis-Golgi network; endoplasmic reticulum; and perinuclear region of cytoplasm. Is expressed in cerebral cortex marginal layer; dorsal root ganglion; orbito-sphenoid; and trigeminal ganglion. Orthologous to human ANGEL1 (angel homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 73.7) and cerebellum adult (RPKM 4.0) See more
Orthologs
human all
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Genomic context

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Location:
12 D2; 12 40.86 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (86740185..86781075, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (86699719..86734303, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:88000594-88000875 Neighboring gene poly(rC) binding protein 2 pseudogene Neighboring gene predicted gene, 22004 Neighboring gene STARR-seq mESC enhancer starr_32830 Neighboring gene vasohibin 1 Neighboring gene pyruvate kinase, muscle pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5342 Neighboring gene predicted gene, 32755 Neighboring gene leucine rich repeat containing 74A Neighboring gene STARR-positive B cell enhancer ABC_E5343 Neighboring gene STARR-positive B cell enhancer ABC_E1448 Neighboring gene STARR-seq mESC enhancer starr_32839 Neighboring gene predicted gene, 53733

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0759

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic initiation factor 4E binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein angel homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144524.2 → NP_653107.2  protein angel homolog 1

    See identical proteins and their annotated locations for NP_653107.2

    Status: VALIDATED

    Source sequence(s)
    AK143549, BQ175854, BY194341, CF173918
    Consensus CDS
    CCDS26067.1
    UniProtKB/Swiss-Prot
    Q5DU16, Q8VCU0
    Related
    ENSMUSP00000021682.9, ENSMUST00000021682.9
    Conserved Domains (1) summary
    cl00490
    Location:245 → 660
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    86740185..86781075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516199.5 → XP_006516262.1  protein angel homolog 1 isoform X2

    See identical proteins and their annotated locations for XP_006516262.1

    Conserved Domains (1) summary
    cl00490
    Location:258 → 673
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. XM_030246896.2 → XP_030102756.1  protein angel homolog 1 isoform X2

    Conserved Domains (1) summary
    cl00490
    Location:258 → 673
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  3. XM_011244169.3 → XP_011242471.1  protein angel homolog 1 isoform X1

    Conserved Domains (1) summary
    cl00490
    Location:268 → 683
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  4. XM_006516200.5 → XP_006516263.1  protein angel homolog 1 isoform X3

    Conserved Domains (1) summary
    cl00490
    Location:199 → 614
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCU0.2 GenPept UniProtKB/Swiss-Prot:Q8VCU0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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