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Rnf166 ring finger protein 166 [ Mus musculus (house mouse) ]

Gene ID: 68718, updated on 5-Mar-2024

Summary

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Official Symbol
Rnf166provided by MGI
Official Full Name
ring finger protein 166provided by MGI
Primary source
MGI:MGI:1915968
See related
Ensembl:ENSMUSG00000014470 AllianceGenome:MGI:1915968
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp313l; 1110031E24Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within autophagy and innate immune response. Predicted to be located in cytoplasm. Orthologous to human RNF166 (ring finger protein 166). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 75.7), adrenal adult (RPKM 60.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf166 in Genome Data Viewer
Location:
8 E1; 8 71.17 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123192884..123202813, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122466145..122476074, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9330133O14 gene Neighboring gene predicted gene, 20735 Neighboring gene snail family zinc finger 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:124993848-124994115 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:124994651-124994852 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:124997832-124998091 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:124999099-124999282 Neighboring gene cytosolic thiouridylase subunit 2 Neighboring gene piezo-type mechanosensitive ion channel component 1 Neighboring gene predicted gene, 26497

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RING-finger protein 166 plays a novel pro-apoptotic role in neurotoxin-induced neurodegeneration via ubiquitination of XIAP. Oh CK, et al. Cell Death Dis, 2020 Oct 31. PMID 33130818, Free PMC Article
  2. Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family. Manzanares M, et al. Dev Genes Evol, 2004 Jan. PMID 14655014
  3. RNF166 plays a dual role for Lys63-linked ubiquitination and sumoylation of its target proteins. Hwang IY, et al. J Neural Transm (Vienna), 2022 Jun. PMID 34837535
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF166
Names
RING-type E3 ubiquitin transferase RNF166
zinc finger protein 313; zinc finger protein 228
NP_001028314.1
NP_001355299.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033142.3 → NP_001028314.1  E3 ubiquitin-protein ligase RNF166 isoform 1

    See identical proteins and their annotated locations for NP_001028314.1

    Status: VALIDATED

    Source sequence(s)
    AC114917
    Consensus CDS
    CCDS22740.1
    UniProtKB/Swiss-Prot
    Q3U9F6
    UniProtKB/TrEMBL
    A2RS02
    Related
    ENSMUSP00000014614.4, ENSMUST00000014614.4
    Conserved Domains (3) summary
    cd16549
    Location:30 → 76
    RING-HC_RNF166; RING finger, HC subclass, found in RING finger protein 166 (RNF166) and similar proteins
    pfam05605
    Location:149 → 208
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam18574
    Location:92 → 124
    zf_C2HC_14; C2HC Zing finger domain

  2. NM_001368370.1 → NP_001355299.1  E3 ubiquitin-protein ligase RNF166 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114917
    Conserved Domains (1) summary
    pfam05605
    Location:40 → 99
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    123192884..123202813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U9F6.1 GenPept UniProtKB/Swiss-Prot:Q3U9F6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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