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Cilp2 cartilage intermediate layer protein 2 [ Mus musculus (house mouse) ]

Gene ID: 68709, updated on 5-Mar-2024

Summary

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Official Symbol
Cilp2provided by MGI
Official Full Name
cartilage intermediate layer protein 2provided by MGI
Primary source
MGI:MGI:1915959
See related
Ensembl:ENSMUSG00000044006 AllianceGenome:MGI:1915959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CLIP-2; 1110031K21Rik
Summary
Predicted to enable carbohydrate binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including heart; liver; lung; musculoskeletal system; and spleen. Orthologous to human CILP2 (cartilage intermediate layer protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 6.0), whole brain E14.5 (RPKM 3.6) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Cilp2 in Genome Data Viewer
Location:
8 B3.3; 8 34.01 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70333016..70340042, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69880366..69887392, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene lysophosphatidic acid receptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E2867 Neighboring gene pre B cell leukemia homeobox 4 Neighboring gene STARR-seq mESC enhancer starr_21749 Neighboring gene predicted gene, 33746 Neighboring gene YjeF N-terminal domain containing 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit A13 Neighboring gene STARR-positive B cell enhancer ABC_E10503 Neighboring gene testis-specific serine kinase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis. Bernardo BC, et al. J Biol Chem, 2011 Oct 28. PMID 21880736, Free PMC Article
  2. O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Du J, et al. Dev Biol, 2010 Oct 1. PMID 20637190, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis.
    Title: Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cartilage intermediate layer protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026818.2 → NP_081094.2  cartilage intermediate layer protein 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC158564
    Consensus CDS
    CCDS40363.1
    UniProtKB/Swiss-Prot
    D3Z7H8
    Related
    ENSMUSP00000061544.8, ENSMUST00000057831.8
    Conserved Domains (5) summary
    smart00408
    Location:307 → 367
    IGc2; Immunoglobulin C-2 Type
    pfam07679
    Location:293 → 375
    I-set; Immunoglobulin I-set domain
    pfam13330
    Location:58 → 143
    Mucin2_WxxW; Mucin-2 protein WxxW repeating region
    pfam13620
    Location:213 → 287
    CarboxypepD_reg; Carboxypeptidase regulatory-like domain
    pfam13715
    Location:476 → 527
    CarbopepD_reg_2; CarboxypepD_reg-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70333016..70340042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3Z7H8.1 GenPept UniProtKB/Swiss-Prot:D3Z7H8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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