Klk5 kallikrein related-peptidase 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klk5provided by MGI
Official Full Name: kallikrein related-peptidase 5provided by MGI
Primary source: MGI:MGI:1915918
See related: Ensembl:ENSMUSG00000074155 AllianceGenome:MGI:1915918
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110030O19Rik
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including amelogenesis; extracellular matrix disassembly; and positive regulation of antibacterial peptide production. Predicted to be located in epidermal lamellar body and extracellular space. Predicted to be active in secretory granule. Orthologous to human KLK5 (kallikrein related peptidase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward stomach adult (RPKM 13.7) See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 28.3 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43483581..43500605)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (43834157..43851181)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KLK5 is associated with the radioresistance, aggression, and progression of cervical cancer.
Title: KLK5 is associated with the radioresistance, aggression, and progression of cervical cancer.
Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis.
Title: Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis.
Exacerbated dandruff in the absence of kallikrein-related peptidase 5 protease.
Title: Exacerbated dandruff in the absence of kallikrein-related peptidase 5 protease.
The epidermis of Klk5-/- mice displays increased number of desmosomes and enhanced mechanical strength. The Klk5-/- mice are resistant to chemically-induced skin tumorigenesis.
Title: Elimination of KLK5 inhibits early skin tumorigenesis by reducing epidermal proteolysis and reinforcing epidermal microstructure.
Ablation of KLK5 is not sufficient to rescue the lethal effect of LEKTI-deficiency. Double deficiency of both KLK5 and KLK7 completely rescues Netherton Syndrome-like phenotype.
Title: KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.
the pruritogenic action of KLK5 may be primarily mediated by PAR2 receptors
Title: Increase in pruritogenic kallikrein 5 in the skin of NC mice with chronic dermatitis.
findings illustrate the crucial role of protease regulation in skin homeostasis and inflammation, and establish KLK5 inhibition as a major therapeutic target for NS
Title: KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome.
The cloning and characteriazation of recombinant Klk5 is reported.
Title: Characterization of mouse tissue kallikrein 5.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amelogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of antibacterial peptide production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of antibacterial peptide production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in epidermal lamellar body	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kallikrein-5

Names: kallikrein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.