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Elac2 elaC ribonuclease Z 2 [ Mus musculus (house mouse) ]

Gene ID: 68626, updated on 21-Apr-2024

Summary

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Official Symbol
Elac2provided by MGI
Official Full Name
elaC ribonuclease Z 2provided by MGI
Primary source
MGI:MGI:1890496
See related
Ensembl:ENSMUSG00000020549 AllianceGenome:MGI:1890496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hpc2; D11Wsu80e; 1110017O07Rik
Summary
Predicted to enable 3'-tRNA processing endoribonuclease activity and tRNA-specific ribonuclease activity. Predicted to be involved in mitochondrial tRNA 3'-trailer cleavage, endonucleolytic. Located in mitochondrial nucleoid. Is expressed in extraembryonic component. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 17. Orthologous to human ELAC2 (elaC ribonuclease Z 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 8.5), ovary adult (RPKM 7.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B3; 11 40.42 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (64869856..64892906)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (64979030..65002080)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30305 Neighboring gene predicted gene 12292 Neighboring gene predicted gene, 40025 Neighboring gene STARR-seq mESC enhancer starr_29760 Neighboring gene STARR-positive B cell enhancer ABC_E2356 Neighboring gene Rho GTPase activating protein 44 Neighboring gene STARR-seq mESC enhancer starr_29762 Neighboring gene STARR-seq mESC enhancer starr_29763 Neighboring gene RIKEN cDNA 1700086D15 gene Neighboring gene predicted gene, 53042 Neighboring gene peroxiredoxin 6 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Concerted regulation of mitochondrial and nuclear non-coding RNAs by a dual-targeted RNase Z. Siira SJ, et al. EMBO Rep, 2018 Oct. PMID 30126926, Free PMC Article
  2. ELAC2 Functions as a Key Gene in the Early Development of Placental Formation Based on WGCNA. Liang J, et al. Cells, 2023 Feb 14. PMID 36831280, Free PMC Article
  3. Functional analyses for tRNase Z variants: an aspartate and a histidine in the active site are essential for the catalytic activity. Elbarbary RA, et al. Biochim Biophys Acta, 2008 Dec. PMID 18809514
  4. A candidate prostate cancer susceptibility gene at chromosome 17p. Tavtigian SV, et al. Nat Genet, 2001 Feb. PMID 11175785
  5. Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids. Bogenhagen DF, et al. Cell Metab, 2014 Apr 1. PMID 24703694

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-tRNA processing endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial tRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc phosphodiesterase ELAC protein 2
Names
RNase Z 2
elaC homolog 2
elaC homolog protein 2
putative prostate cancer susceptibility protein
ribonuclease Z 2
tRNA 3 endonuclease 2
tRNase Z 2
tRNase Z(L)
NP_001349911.1
NP_001349912.1
NP_001349913.1
NP_075968.2
XP_006534128.1
XP_006534129.1
XP_006534130.1
XP_006534131.1
XP_030102124.1
XP_036012824.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362982.1 → NP_001349911.1  zinc phosphodiesterase ELAC protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL663045
    UniProtKB/TrEMBL
    B1ATP7
    Conserved Domains (2) summary
    cd07718
    Location:479 → 689
    RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
    cd16296
    Location:52 → 307
    RNaseZ_ELAC2-N-term-like_MBL-fold; Ribonuclease Z, N-terminus of human ELAC2 and related proteins; MBL-fold metallo-hydrolase domain

  2. NM_001362983.1 → NP_001349912.1  zinc phosphodiesterase ELAC protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL663045
    Consensus CDS
    CCDS88171.1
    UniProtKB/TrEMBL
    B1ATP7
    Related
    ENSMUSP00000098610.3, ENSMUST00000101049.9
    Conserved Domains (2) summary
    cd07718
    Location:479 → 684
    RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
    cd16296
    Location:52 → 307
    RNaseZ_ELAC2-N-term-like_MBL-fold; Ribonuclease Z, N-terminus of human ELAC2 and related proteins; MBL-fold metallo-hydrolase domain

  3. NM_001362984.1 → NP_001349913.1  zinc phosphodiesterase ELAC protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL663045
    Related
    ENSMUST00000140369.2
    Conserved Domains (1) summary
    cd07718
    Location:111 → 316
    RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain

  4. NM_023479.3 → NP_075968.2  zinc phosphodiesterase ELAC protein 2 isoform 1

    See identical proteins and their annotated locations for NP_075968.2

    Status: VALIDATED

    Source sequence(s)
    AL663045, BC048235
    Consensus CDS
    CCDS24841.1
    UniProtKB/Swiss-Prot
    B1ATP6, Q80Y81, Q99MF0, Q99MF1, Q9CTA2, Q9D1A8, Q9EPZ2
    UniProtKB/TrEMBL
    B1ATP7, Q3U0M8
    Related
    ENSMUSP00000071788.6, ENSMUST00000071891.12
    Conserved Domains (3) summary
    COG1234
    Location:478 → 748
    ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]
    cd07718
    Location:479 → 684
    RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
    cd16296
    Location:52 → 307
    RNaseZ_ELAC2-N-term-like_MBL-fold; Ribonuclease Z, N-terminus of human ELAC2 and related proteins; MBL-fold metallo-hydrolase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    64869856..64892906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534065.3 → XP_006534128.1  zinc phosphodiesterase ELAC protein 2 isoform X1

    UniProtKB/TrEMBL
    B1ATP7
    Conserved Domains (2) summary
    cd07718
    Location:479 → 689
    RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
    cd16296
    Location:52 → 307
    RNaseZ_ELAC2-N-term-like_MBL-fold; Ribonuclease Z, N-terminus of human ELAC2 and related proteins; MBL-fold metallo-hydrolase domain

  2. XM_006534067.3 → XP_006534130.1  zinc phosphodiesterase ELAC protein 2 isoform X4

    Conserved Domains (1) summary
    cd07718
    Location:111 → 321
    RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain

  3. XM_006534068.2 → XP_006534131.1  zinc phosphodiesterase ELAC protein 2 isoform X5

    Conserved Domains (1) summary
    cd07718
    Location:111 → 316
    RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain

  4. XM_006534066.4 → XP_006534129.1  zinc phosphodiesterase ELAC protein 2 isoform X2

    UniProtKB/TrEMBL
    B1ATP7
    Conserved Domains (2) summary
    cd07718
    Location:375 → 585
    RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
    cl23716
    Location:1 → 203
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

  5. XM_036156931.1 → XP_036012824.1  zinc phosphodiesterase ELAC protein 2 isoform X4

    Conserved Domains (1) summary
    cd07718
    Location:111 → 321
    RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain

  6. XM_030246264.2 → XP_030102124.1  zinc phosphodiesterase ELAC protein 2 isoform X3

    UniProtKB/TrEMBL
    B1ATP7
    Conserved Domains (2) summary
    cd07718
    Location:375 → 580
    RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
    cl23716
    Location:1 → 203
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80Y81.1 GenPept UniProtKB/Swiss-Prot:Q80Y81

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