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Dnajc8 DnaJ heat shock protein family (Hsp40) member C8 [ Mus musculus (house mouse) ]

Gene ID: 68598, updated on 5-Mar-2024

Summary

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Official Symbol
Dnajc8provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C8provided by MGI
Primary source
MGI:MGI:1915848
See related
Ensembl:ENSMUSG00000054405 AllianceGenome:MGI:1915848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110021D09Rik; 2010009J04Rik
Summary
Predicted to enable Hsp70 protein binding activity. Predicted to be located in cytosol; intercellular bridge; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system and retina. Orthologous to human DNAJC8 (DnaJ heat shock protein family (Hsp40) member C8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 60.5), liver E14 (RPKM 51.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.3; 4 65.52 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132262859..132281053)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132535559..132553742)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11570 Neighboring gene STARR-seq mESC enhancer starr_11571 Neighboring gene STARR-seq mESC enhancer starr_11572 Neighboring gene nuclear encoded tRNA alanine 8 (anticodon AGC) Neighboring gene STARR-positive B cell enhancer ABC_E9240 Neighboring gene STARR-positive B cell enhancer ABC_E9013 Neighboring gene ATP synthase inhibitory factor subunit 1 Neighboring gene predicted gene, 24762 Neighboring gene predicted gene, 54261 Neighboring gene STARR-positive B cell enhancer ABC_E10263 Neighboring gene platelet-activating factor receptor Neighboring gene STARR-seq mESC enhancer starr_11574 Neighboring gene STARR-seq mESC enhancer starr_11575 Neighboring gene STARR-seq mESC enhancer starr_11576 Neighboring gene EYA transcriptional coactivator and phosphatase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article
  2. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
  3. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
  4. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
  5. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 8
Names
DnaJ (Hsp40) homolog, subfamily C, member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172400.3 → NP_765988.2  dnaJ homolog subfamily C member 8

    See identical proteins and their annotated locations for NP_765988.2

    Status: VALIDATED

    Source sequence(s)
    AK168645, BC064732, BY754536
    Consensus CDS
    CCDS51319.1
    UniProtKB/Swiss-Prot
    Q6NZB0, Q6PG72, Q8C2M6
    UniProtKB/TrEMBL
    A2ALF0, A2ALF2
    Related
    ENSMUSP00000092242.4, ENSMUST00000094657.10
    Conserved Domains (2) summary
    cd06257
    Location:57 → 112
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    COG2214
    Location:51 → 238
    CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132262859..132281053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164392.1 → XP_036020285.1  dnaJ homolog subfamily C member 8 isoform X1

    Conserved Domains (2) summary
    cd06257
    Location:76 → 131
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    COG2214
    Location:70 → 257
    CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NZB0.2 GenPept UniProtKB/Swiss-Prot:Q6NZB0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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