U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mocos molybdenum cofactor sulfurase [ Mus musculus (house mouse) ]

Gene ID: 68591, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Mocosprovided by MGI
Official Full Name
molybdenum cofactor sulfuraseprovided by MGI
Primary source
MGI:MGI:1915841
See related
Ensembl:ENSMUSG00000039616 AllianceGenome:MGI:1915841
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MCS; MOS; HMCS; 1110018O12Rik
Summary
Predicted to enable Mo-molybdopterin cofactor sulfurase activity. Predicted to be involved in molybdopterin cofactor metabolic process. Is expressed in naris and olfactory epithelium. Human ortholog(s) of this gene implicated in xanthinuria. Orthologous to human MOCOS (molybdenum cofactor sulfurase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 11.8), small intestine adult (RPKM 5.9) and 19 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
18 A2; 18 13.18 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (24786538..24834634)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (24653492..24701577)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8706 Neighboring gene solute carrier family 39 (metal ion transporter), member 6 Neighboring gene STARR-positive B cell enhancer mm9_chr18:24835661-24835962 Neighboring gene elongator acetyltransferase complex subunit 2 Neighboring gene formin homology 2 domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_44073 Neighboring gene 39S ribosomal protein L42, mitochondrial pseudogene Neighboring gene STARR-seq mESC enhancer starr_44075 Neighboring gene tubulin polyglutamylase complex subunit 2 Neighboring gene expressed sequence AW554918

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Deletion of Mocos Induces Xanthinuria with Obstructive Nephropathy and Major Metabolic Disorders in Mice. Sedda D, et al. Kidney360, 2021 Nov 25. PMID 35372998, Free PMC Article
  2. Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II. Ichida K, et al. Biochem Biophys Res Commun, 2001 Apr 20. PMID 11302742
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Mo-molybdopterin cofactor sulfurase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Mo-molybdopterin cofactor sulfurase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables molybdenum cofactor sulfurtransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables molybdenum ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in Mo-molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in molybdopterin cofactor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in molybdopterin cofactor metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in molybdopterin cofactor metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

Go to the top of the page Help
Preferred Names
molybdenum cofactor sulfurase
Names
moCo sulfurase
molybdenum cofactor sulfurtransferase
NP_081055.1
XP_006526274.1
XP_011245296.1
XP_036017163.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026779.1 → NP_081055.1  molybdenum cofactor sulfurase

    See identical proteins and their annotated locations for NP_081055.1

    Status: PROVISIONAL

    Source sequence(s)
    BC113180
    Consensus CDS
    CCDS37750.1
    UniProtKB/Swiss-Prot
    Q14CH1
    Related
    ENSMUSP00000063609.8, ENSMUST00000068006.9
    Conserved Domains (4) summary
    PLN02724
    Location:28 → 854
    PLN02724; Molybdenum cofactor sulfurase
    pfam03473
    Location:720 → 852
    MOSC; MOSC domain
    pfam03476
    Location:572 → 688
    MOSC_N; MOSC N-terminal beta barrel domain
    cl18945
    Location:50 → 482
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    24786538..24834634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526211.5 → XP_006526274.1  molybdenum cofactor sulfurase isoform X1

    Conserved Domains (1) summary
    PLN02724
    Location:28 → 824
    PLN02724; Molybdenum cofactor sulfurase

  2. XM_011246994.4 → XP_011245296.1  molybdenum cofactor sulfurase isoform X2

    Conserved Domains (1) summary
    PLN02724
    Location:28 → 744
    PLN02724; Molybdenum cofactor sulfurase

  3. XM_036161270.1 → XP_036017163.1  molybdenum cofactor sulfurase isoform X3

    Related
    ENSMUST00000234253.2
    Conserved Domains (1) summary
    PLN02724
    Location:28 → 712
    PLN02724; Molybdenum cofactor sulfurase

RNA

  1. XR_877139.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14CH1.1 GenPept UniProtKB/Swiss-Prot:Q14CH1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous