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Uckl1 uridine-cytidine kinase 1-like 1 [ Mus musculus (house mouse) ]

Gene ID: 68556, updated on 11-Apr-2024

Summary

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Official Symbol
Uckl1provided by MGI
Official Full Name
uridine-cytidine kinase 1-like 1provided by MGI
Primary source
MGI:MGI:1915806
See related
Ensembl:ENSMUSG00000089917 AllianceGenome:MGI:1915806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Urkl1; 1110007H10Rik
Summary
Predicted to enable ATP binding activity and uridine kinase activity. Predicted to be involved in nucleoside metabolic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in central nervous system; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human UCKL1 (uridine-cytidine kinase 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 15.0), thymus adult (RPKM 14.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H4; 2 103.66 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181210942..181223820, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181569149..181582027, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene tumor protein D52-like 2 Neighboring gene predicted gene, 25184 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 Neighboring gene STARR-positive B cell enhancer ABC_E3426 Neighboring gene uridine-cytidine kinase 1-like 1, opposite strand Neighboring gene zinc finger protein 512B Neighboring gene microRNA 7006 Neighboring gene sterile alpha motif domain containing 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancer.
    Title: Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancer.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables uridine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uridine-cytidine kinase-like 1
Names
uridine kinase-like 1
NP_001365934.1
NP_081041.2
XP_006500767.1
XP_006500768.1
XP_006500769.1
XP_006500772.1
XP_006500773.1
XP_011238262.1
XP_030107893.1
XP_030107894.1
XP_030107895.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379005.1 → NP_001365934.1  uridine-cytidine kinase-like 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL844529
    Conserved Domains (2) summary
    cd02023
    Location:101 → 299
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:330 → 533
    UPRTase; Uracil phosphoribosyltransferase

  2. NM_026765.3 → NP_081041.2  uridine-cytidine kinase-like 1 isoform 2

    See identical proteins and their annotated locations for NP_081041.2

    Status: VALIDATED

    Source sequence(s)
    AL844529
    Consensus CDS
    CCDS17216.1
    UniProtKB/Swiss-Prot
    Q91YL3
    Related
    ENSMUSP00000050398.9, ENSMUST00000057816.15
    Conserved Domains (3) summary
    COG0572
    Location:93 → 306
    Udk; Uridine kinase [Nucleotide transport and metabolism]
    cd02023
    Location:101 → 299
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:329 → 532
    UPRTase; Uracil phosphoribosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    181210942..181223820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500709.4 → XP_006500772.1  uridine-cytidine kinase-like 1 isoform X7

    See identical proteins and their annotated locations for XP_006500772.1

    Conserved Domains (2) summary
    cd02023
    Location:1 → 183
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:214 → 417
    UPRTase; Uracil phosphoribosyltransferase

  2. XM_030252033.1 → XP_030107893.1  uridine-cytidine kinase-like 1 isoform X1

    Conserved Domains (2) summary
    cd02023
    Location:100 → 298
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:329 → 532
    UPRTase; Uracil phosphoribosyltransferase

  3. XM_030252034.1 → XP_030107894.1  uridine-cytidine kinase-like 1 isoform X2

    Conserved Domains (2) summary
    cd02023
    Location:100 → 298
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:328 → 531
    UPRTase; Uracil phosphoribosyltransferase

  4. XM_006500704.4 → XP_006500767.1  uridine-cytidine kinase-like 1 isoform X3

    Conserved Domains (2) summary
    cd02023
    Location:86 → 284
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:315 → 518
    UPRTase; Uracil phosphoribosyltransferase

  5. XM_006500705.4 → XP_006500768.1  uridine-cytidine kinase-like 1 isoform X4

    Conserved Domains (2) summary
    cd02023
    Location:86 → 284
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:314 → 517
    UPRTase; Uracil phosphoribosyltransferase

  6. XM_006500706.5 → XP_006500769.1  uridine-cytidine kinase-like 1 isoform X5

    Conserved Domains (2) summary
    cd02023
    Location:85 → 283
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:314 → 517
    UPRTase; Uracil phosphoribosyltransferase

  7. XM_030252035.2 → XP_030107895.1  uridine-cytidine kinase-like 1 isoform X6

    Conserved Domains (2) summary
    cd02023
    Location:85 → 283
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:313 → 516
    UPRTase; Uracil phosphoribosyltransferase

  8. XM_006500710.5 → XP_006500773.1  uridine-cytidine kinase-like 1 isoform X7

    See identical proteins and their annotated locations for XP_006500773.1

    Conserved Domains (2) summary
    cd02023
    Location:1 → 183
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    pfam14681
    Location:214 → 417
    UPRTase; Uracil phosphoribosyltransferase

  9. XM_011239960.3 → XP_011238262.1  uridine-cytidine kinase-like 1 isoform X8

    Conserved Domains (2) summary
    pfam14681
    Location:109 → 312
    UPRTase; Uracil phosphoribosyltransferase
    cl17190
    Location:1 → 78
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YL3.1 GenPept UniProtKB/Swiss-Prot:Q91YL3

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