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Trir telomerase RNA component interacting RNase [ Mus musculus (house mouse) ]

Gene ID: 68544, updated on 5-Mar-2024

Summary

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Official Symbol
Trirprovided by MGI
Official Full Name
telomerase RNA component interacting RNaseprovided by MGI
Primary source
MGI:MGI:1922833
See related
Ensembl:ENSMUSG00000041203 AllianceGenome:MGI:1922833
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110002H14Rik; 2310036O22Rik
Summary
Predicted to enable 3'-5' exonuclease activity and 5'-3' exonuclease activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, exonucleolytic and rRNA catabolic process. Orthologous to human TRIR (telomerase RNA component interacting RNase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 80.0), CNS E14 (RPKM 55.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Trir in Genome Data Viewer
Location:
8 C3; 8 41.49 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85753440..85756920)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (85026811..85030291)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene bestrophin 2 Neighboring gene STARR-seq mESC enhancer starr_22148 Neighboring gene guided entry of tail-anchored proteins factor 3, ATPase Neighboring gene STARR-positive B cell enhancer ABC_E884 Neighboring gene STARR-positive B cell enhancer ABC_E8254 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87560506-87560689 Neighboring gene transportin 2 (importin 3, karyopherin beta 2b) Neighboring gene RIKEN cDNA A230103J11 gene Neighboring gene predicted gene, 25506 Neighboring gene STARR-seq mESC enhancer starr_22150 Neighboring gene F-box and WD-40 domain protein 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan). White RA, et al. Blood Cells Mol Dis, 2009 Sep-Oct. PMID 19409822
  2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5' exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables 5'-3' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-3' exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in rRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
telomerase RNA component interacting RNase
Names
exoribonuclease Trir
exoribonuclease TrirR
uncharacterized protein C19orf43 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026760.3 → NP_081036.2  telomerase RNA component interacting RNase

    See identical proteins and their annotated locations for NP_081036.2

    Status: VALIDATED

    Source sequence(s)
    AC163703
    Consensus CDS
    CCDS22490.1
    UniProtKB/Swiss-Prot
    Q9D1N3, Q9D735
    Related
    ENSMUSP00000044129.9, ENSMUST00000047281.10

RNA

  1. NR_160793.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163703

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85753440..85756920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243748.1 → XP_030099608.1  telomerase RNA component interacting RNase isoform X2

  2. XM_030243747.2 → XP_030099607.1  telomerase RNA component interacting RNase isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D735.1 GenPept UniProtKB/Swiss-Prot:Q9D735

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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