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Mphosph6 M phase phosphoprotein 6 [ Mus musculus (house mouse) ]

Gene ID: 68533, updated on 5-Mar-2024

Summary

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Official Symbol
Mphosph6provided by MGI
Official Full Name
M phase phosphoprotein 6provided by MGI
Primary source
MGI:MGI:1915783
See related
Ensembl:ENSMUSG00000031843 AllianceGenome:MGI:1915783
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110001M01Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA. Predicted to act upstream of or within rRNA processing. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of nuclear exosome (RNase complex). Is expressed in left lung; orbito-sphenoid; right lung; and testis. Orthologous to human MPHOSPH6 (M-phase phosphoprotein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 17.2), CNS E11.5 (RPKM 15.7) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 65.09 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (118518376..118528713, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (117791637..117801974, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 2 Neighboring gene predicted gene, 31774 Neighboring gene STARR-positive B cell enhancer mm9_chr8:120303396-120303696 Neighboring gene STARR-positive B cell enhancer ABC_E9744 Neighboring gene predicted gene, 39261 Neighboring gene STARR-positive B cell enhancer ABC_E1377 Neighboring gene predicted gene, 39262 Neighboring gene predicted gene, 25200

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The 5.8S pre-rRNA maturation factor, M-phase phosphoprotein 6, is a female fertility factor required for oocyte quality and meiosis. Peng RR, et al. Cell Prolif, 2020 Mar. PMID 32003502, Free PMC Article
  2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of 5.8S rRNA ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
M-phase phosphoprotein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357232.1 → NP_001344161.1  M-phase phosphoprotein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122036
    Conserved Domains (1) summary
    pfam10175
    Location:1 → 118
    MPP6; M-phase phosphoprotein 6

  2. NM_001357233.1 → NP_001344162.1  M-phase phosphoprotein 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122036
    Conserved Domains (1) summary
    pfam10175
    Location:8 → 134
    MPP6; M-phase phosphoprotein 6

  3. NM_026758.4 → NP_081034.1  M-phase phosphoprotein 6 isoform 1

    See identical proteins and their annotated locations for NP_081034.1

    Status: VALIDATED

    Source sequence(s)
    AC122036, AK003245, AU022509, CJ084018, DV660881
    Consensus CDS
    CCDS22702.1
    UniProtKB/Swiss-Prot
    Q9D1Q1
    Related
    ENSMUSP00000034303.2, ENSMUST00000034303.3
    Conserved Domains (1) summary
    pfam10175
    Location:8 → 136
    MPP6; M-phase phosphoprotein 6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    118518376..118528713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D1Q1.1 GenPept UniProtKB/Swiss-Prot:Q9D1Q1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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