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Gpr155 G protein-coupled receptor 155 [ Mus musculus (house mouse) ]

Gene ID: 68526, updated on 5-Mar-2024

Summary

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Official Symbol
Gpr155provided by MGI
Official Full Name
G protein-coupled receptor 155provided by MGI
Primary source
MGI:MGI:1915776
See related
Ensembl:ENSMUSG00000041762 AllianceGenome:MGI:1915776
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PGR22; DEPDC3; LYCHOS; 1110017O10Rik; F730029F15Rik
Summary
Predicted to be involved in cognition. Is expressed in several structures, including brain; genitourinary system; liver; spinal cord; and spleen. Orthologous to human GPR155 (G protein-coupled receptor 155). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 5.0), genital fat pad adult (RPKM 4.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Gpr155 in Genome Data Viewer
Location:
2 C3; 2 43.59 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (73171850..73216842, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (73341506..73386521, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene corepressor interacting with RBPJ, 1 Neighboring gene STARR-positive B cell enhancer ABC_E2622 Neighboring gene secernin 3 Neighboring gene STARR-seq mESC enhancer starr_04837 Neighboring gene predicted gene 13709 Neighboring gene STARR-positive B cell enhancer mm9_chr2:73224453-73224754 Neighboring gene predicted gene 13707 Neighboring gene STARR-positive B cell enhancer ABC_E2623 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:73288549-73288732 Neighboring gene WAS/WASL interacting protein family, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E4467 Neighboring gene STARR-positive B cell enhancer ABC_E1245 Neighboring gene STARR-positive B cell enhancer ABC_E5934 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:73324434-73324587 Neighboring gene STARR-positive B cell enhancer ABC_E2038 Neighboring gene predicted gene, 54162

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GPR155: Gene organization, multiple mRNA splice variants and expression in mouse central nervous system. Trifonov S, et al. Biochem Biophys Res Commun, 2010 Jul 16. PMID 20537985
  2. Searching for genomic region of high-fat diet-induced type 2 diabetes in mouse chromosome 2 by analysis of congenic strains. Kobayashi M, et al. PLoS One, 2014. PMID 24789282, Free PMC Article
  3. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • 1110017O10Rik, F730029F15Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to cholesterol ISO
Inferred from Sequence Orthology
more info
  
involved_in cognition ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysosomal cholesterol signaling protein
Names
integral membrane protein GPR155

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190297.2 → NP_001177226.1  lysosomal cholesterol signaling protein isoform 1

    See identical proteins and their annotated locations for NP_001177226.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL954713, AV115983, HM161763
    Consensus CDS
    CCDS50606.1
    UniProtKB/Swiss-Prot
    A2AWR2, A2AWR3, D7RXL9, D7RXM0, Q14BN5, Q80UC0, Q8R0W2
    Related
    ENSMUSP00000075788.6, ENSMUST00000076463.12
    Conserved Domains (2) summary
    cd04443
    Location:749 → 831
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:36 → 364
    Mem_trans; Membrane transport protein

  2. NM_001276443.1 → NP_001263372.1  lysosomal cholesterol signaling protein isoform 3

    See identical proteins and their annotated locations for NP_001263372.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL954713, AV115983, HM161764
    UniProtKB/TrEMBL
    D7RXL9
    Conserved Domains (2) summary
    cl02442
    Location:749 → 776
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
    cl22894
    Location:36 → 364
    Mem_trans; Membrane transport protein

  3. NM_001276444.1 → NP_001263373.1  lysosomal cholesterol signaling protein isoform 4

    See identical proteins and their annotated locations for NP_001263373.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1.
    Source sequence(s)
    AL954713, AV115983, HM161766
    Consensus CDS
    CCDS71075.1
    UniProtKB/TrEMBL
    A2AWR2
    Related
    ENSMUSP00000107675.2, ENSMUST00000112044.8
    Conserved Domains (2) summary
    cd04443
    Location:721 → 803
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:36 → 364
    Mem_trans; Membrane transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    73171850..73216842 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500106.3 → XP_006500169.1  lysosomal cholesterol signaling protein isoform X2

    See identical proteins and their annotated locations for XP_006500169.1

    UniProtKB/Swiss-Prot
    A2AWR2, A2AWR3, D7RXL9, D7RXM0, Q14BN5, Q80UC0, Q8R0W2
    Conserved Domains (2) summary
    cd04443
    Location:749 → 831
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:36 → 364
    Mem_trans; Membrane transport protein

  2. XM_006500104.3 → XP_006500167.1  lysosomal cholesterol signaling protein isoform X1

    See identical proteins and their annotated locations for XP_006500167.1

    Conserved Domains (2) summary
    cd04443
    Location:762 → 844
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:49 → 377
    Mem_trans; Membrane transport protein

  3. XM_006500105.3 → XP_006500168.1  lysosomal cholesterol signaling protein isoform X1

    See identical proteins and their annotated locations for XP_006500168.1

    Conserved Domains (2) summary
    cd04443
    Location:762 → 844
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:49 → 377
    Mem_trans; Membrane transport protein

  4. XM_006500107.4 → XP_006500170.1  lysosomal cholesterol signaling protein isoform X3

    Related
    ENSMUST00000048504.10
    Conserved Domains (2) summary
    cl22894
    Location:49 → 377
    Mem_trans; Membrane transport protein
    cl02442
    Location:762 → 789
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

  5. XM_006500108.5 → XP_006500171.1  lysosomal cholesterol signaling protein isoform X4

    Conserved Domains (2) summary
    cl22894
    Location:49 → 377
    Mem_trans; Membrane transport protein
    cl02442
    Location:762 → 790
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080707.1: Suppressed sequence

    Description
    NM_001080707.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AWR3.1 GenPept UniProtKB/Swiss-Prot:A2AWR3

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