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Entrep3 endosomal transmembrane epsin interactor 3 [ Mus musculus (house mouse) ]

Gene ID: 68521, updated on 5-Mar-2024

Summary

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Official Symbol
Entrep3provided by MGI
Official Full Name
endosomal transmembrane epsin interactor 3provided by MGI
Primary source
MGI:MGI:1915771
See related
Ensembl:ENSMUSG00000032657 AllianceGenome:MGI:1915771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam189b; 1110013L07Rik
Summary
Predicted to enable WW domain binding activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human FAM189B (family with sequence similarity 189 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 29.1), limb E14.5 (RPKM 19.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F1; 3 39.01 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89089996..89096598)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89183143..89189291)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene pyruvate kinase liver and red blood cell Neighboring gene hyperpolarization-activated, cyclic nucleotide-gated K+ 3 Neighboring gene predicted gene, 45927 Neighboring gene CDC-like kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E2079 Neighboring gene secretory carrier membrane protein 3 Neighboring gene predicted gene 16069 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:88994426-88994609 Neighboring gene STARR-positive B cell enhancer ABC_E275 Neighboring gene STARR-positive B cell enhancer ABC_E10196 Neighboring gene predicted gene, 23269 Neighboring gene glucosylceramidase beta 1 Neighboring gene metaxin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ectopic overexpression of COTE1 promotes cellular invasion of hepatocellular carcinoma. Zhang H, et al. Asian Pac J Cancer Prev, 2012. PMID 23317259
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein ENTREP3
Names
family with sequence similarity 189, member B
protein FAM189B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014995.2 → NP_001014995.1  protein ENTREP3 isoform 1

    See identical proteins and their annotated locations for NP_001014995.1

    Status: VALIDATED

    Source sequence(s)
    AC161600, BC088990
    Consensus CDS
    CCDS17492.1
    UniProtKB/Swiss-Prot
    Q5HZJ5
    UniProtKB/TrEMBL
    E9Q6P6
    Related
    ENSMUSP00000039261.7, ENSMUST00000041913.13
    Conserved Domains (1) summary
    pfam04103
    Location:36 → 196
    CD20; CD20-like family

  2. NM_001355760.1 → NP_001342689.1  protein ENTREP3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161600, BC085505
    UniProtKB/TrEMBL
    E9Q6P6
    Conserved Domains (1) summary
    pfam04103
    Location:1 → 90
    CD20; CD20-like family

  3. NM_001355765.1 → NP_001342694.1  protein ENTREP3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC161600, BC068123

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89089996..89096598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163265.1 → XP_036019158.1  protein ENTREP3 isoform X1

    UniProtKB/Swiss-Prot
    Q5HZJ5
    UniProtKB/TrEMBL
    E9Q6P6
    Conserved Domains (1) summary
    pfam04103
    Location:36 → 196
    CD20; CD20-like family

  2. XM_006501981.3 → XP_006502044.1  protein ENTREP3 isoform X7

  3. XM_030252778.2 → XP_030108638.1  protein ENTREP3 isoform X5

    UniProtKB/TrEMBL
    E9Q6P6
    Conserved Domains (1) summary
    pfam04103
    Location:1 → 90
    CD20; CD20-like family

  4. XM_030252777.2 → XP_030108637.1  protein ENTREP3 isoform X6

    UniProtKB/TrEMBL
    E9Q6P6
    Conserved Domains (1) summary
    pfam04103
    Location:1 → 90
    CD20; CD20-like family

  5. XM_006501977.5 → XP_006502040.1  protein ENTREP3 isoform X2

    See identical proteins and their annotated locations for XP_006502040.1

    UniProtKB/TrEMBL
    E9Q6P6
    Related
    ENSMUSP00000113579.2, ENSMUST00000119707.2
    Conserved Domains (1) summary
    pfam04103
    Location:36 → 196
    CD20; CD20-like family

  6. XM_006501978.5 → XP_006502041.1  protein ENTREP3 isoform X3

    UniProtKB/TrEMBL
    E9Q6C9, E9Q6P6
    Related
    ENSMUSP00000113706.2, ENSMUST00000117278.8
    Conserved Domains (1) summary
    pfam04103
    Location:36 → 177
    CD20; CD20-like family

  7. XM_030252776.2 → XP_030108636.1  protein ENTREP3 isoform X4

    UniProtKB/TrEMBL
    E9Q6P6
    Conserved Domains (1) summary
    pfam04103
    Location:36 → 177
    CD20; CD20-like family

  8. XM_036163266.1 → XP_036019159.1  protein ENTREP3 isoform X7

RNA

  1. XR_001783738.3 RNA Sequence

    Related
    ENSMUST00000147696.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5HZJ5.1 GenPept UniProtKB/Swiss-Prot:Q5HZJ5

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