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Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase [ Mus musculus (house mouse) ]

Gene ID: 68501, updated on 11-Apr-2024

Summary

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Official Symbol
Nsmce2provided by MGI
Official Full Name
NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligaseprovided by MGI
Primary source
MGI:MGI:1915751
See related
Ensembl:ENSMUSG00000059586 AllianceGenome:MGI:1915751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110014D18Rik
Summary
Predicted to enable SUMO ligase activity. Predicted to be involved in several processes, including DNA recombination; positive regulation of cell cycle process; and protein sumoylation. Predicted to act upstream of or within DNA recombination; DNA repair; and cell division. Predicted to be located in PML body and chromosome, telomeric region. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Is expressed in brain; spermatocyte; and testis. Used to study Bloom syndrome. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.9), placenta adult (RPKM 4.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D1; 15 25.19 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (59246047..59473538)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (59374198..59601689)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene squalene epoxidase Neighboring gene WASH complex subunit 5 Neighboring gene STARR-positive B cell enhancer ABC_E8593 Neighboring gene STARR-seq mESC enhancer starr_38785 Neighboring gene STARR-seq mESC enhancer starr_38787 Neighboring gene STARR-seq mESC enhancer starr_38788 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:59356284-59356467 Neighboring gene STARR-seq mESC enhancer starr_38791 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:59403555-59403708 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:59429020-59429203 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:59429225-59429438 Neighboring gene STARR-seq mESC enhancer starr_38794 Neighboring gene STARR-seq mESC enhancer starr_38795 Neighboring gene STARR-positive B cell enhancer ABC_E7372 Neighboring gene predicted gene, 36677 Neighboring gene STARR-seq mESC enhancer starr_38797 Neighboring gene tribbles pseudokinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The E3 SUMO ligase Nse2 regulates sumoylation and nuclear-to-cytoplasmic translocation of skNAC-Smyd1 in myogenesis. Berkholz J, et al. J Cell Sci, 2014 Sep 1. PMID 25002400
  2. SUMO E3 ligase HIGH PLOIDY2 regulates endocycle onset and meristem maintenance in Arabidopsis. Ishida T, et al. Plant Cell, 2009 Aug. PMID 19666737, Free PMC Article
  3. NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity. Jacome A, et al. EMBO J, 2015 Nov 3. PMID 26443207, Free PMC Article
  4. SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes. Hwang G, et al. Development, 2017 May 1. PMID 28302748, Free PMC Article
  5. Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase. Gur I, et al. PLoS One, 2014. PMID 24911587, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUMO- and BLM-independent activities of NSMCE2 limit recombination and facilitate chromosome segregation.
    Title: NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular senescence ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of maintenance of mitotic sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance via recombination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
part_of Smc5-Smc6 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Smc5-Smc6 complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 SUMO-protein ligase NSE2
Names
E3 SUMO-protein transferase NSE2
MMS21 homolog
non-SMC element 2 homolog (MMS21, S. cerevisiae)
non-structural maintenance of chromosomes element 2 homolog
NP_001158076.1
NP_001361697.1
NP_081022.2
XP_006521380.1
XP_017172226.1
XP_030104584.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164604.1 → NP_001158076.1  E3 SUMO-protein ligase NSE2 isoform 2

    See identical proteins and their annotated locations for NP_001158076.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK051277, BE991399, DV057668
    Consensus CDS
    CCDS49611.1
    UniProtKB/Swiss-Prot
    Q91VT1
    Related
    ENSMUSP00000128893.2, ENSMUST00000168722.3

  2. NM_001374768.1 → NP_001361697.1  E3 SUMO-protein ligase NSE2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC107764, AC113269, AC161172
    Consensus CDS
    CCDS88769.1
    UniProtKB/TrEMBL
    A0A2I3BS18
    Related
    ENSMUSP00000154811.2, ENSMUST00000227173.2
    Conserved Domains (1) summary
    cd16651
    Location:193 → 262
    SPL-RING_NSE2; SPL-RING finger found in E3 SUMO-protein ligase NSE2 and similar proteins

  3. NM_026746.3 → NP_081022.2  E3 SUMO-protein ligase NSE2 isoform 1

    See identical proteins and their annotated locations for NP_081022.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1).
    Source sequence(s)
    AK003685, AW489283, DV057668
    Consensus CDS
    CCDS27498.1
    UniProtKB/Swiss-Prot
    Q8BQ88, Q91VT1, Q9D1D3
    Related
    ENSMUSP00000078641.4, ENSMUST00000079703.11
    Conserved Domains (1) summary
    pfam11789
    Location:156 → 216
    zf-Nse; Zinc-finger of the MIZ type in Nse subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    59246047..59473538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316737.3 → XP_017172226.1  E3 SUMO-protein ligase NSE2 isoform X2

    Conserved Domains (1) summary
    cl17238
    Location:182 → 231
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_030248724.2 → XP_030104584.1  E3 SUMO-protein ligase NSE2 isoform X3

    Conserved Domains (1) summary
    cl17238
    Location:156 → 205
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_006521317.5 → XP_006521380.1  E3 SUMO-protein ligase NSE2 isoform X1

    Conserved Domains (1) summary
    cd16651
    Location:192 → 261
    SPL-RING_NSE2; SPL-RING finger found in E3 SUMO-protein ligase NSE2 and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VT1.1 GenPept UniProtKB/Swiss-Prot:Q91VT1

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