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Arel1 apoptosis resistant E3 ubiquitin protein ligase 1 [ Mus musculus (house mouse) ]

Gene ID: 68497, updated on 5-Mar-2024

Summary

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Official Symbol
Arel1provided by MGI
Official Full Name
apoptosis resistant E3 ubiquitin protein ligase 1provided by MGI
Primary source
MGI:MGI:1915747
See related
Ensembl:ENSMUSG00000042350 AllianceGenome:MGI:1915747
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110018G07Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Involved in protein ubiquitination; regulation of inflammatory response; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 22.2), CNS E18 (RPKM 18.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 D1; 12 39.46 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84964914..85017674, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84918140..84970878, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene iron-sulfur cluster assembly 2 Neighboring gene latent transforming growth factor beta binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_32756 Neighboring gene STARR-seq mESC enhancer starr_32757 Neighboring gene RIKEN cDNA D030025P21 gene Neighboring gene STARR-positive B cell enhancer ABC_E7160 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86311736-86311923 Neighboring gene STARR-positive B cell enhancer ABC_E1446 Neighboring gene STARR-seq mESC enhancer starr_32760 Neighboring gene FCF1 rRNA processing protein Neighboring gene STARR-seq mESC enhancer starr_32761 Neighboring gene YLP motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_32762

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KIAA0317 regulates pulmonary inflammation through SOCS2 degradation. Lear TB, et al. JCI Insight, 2019 Oct 3. PMID 31578312, Free PMC Article
  2. Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4. Lear T, et al. J Exp Med, 2016 May 30. PMID 27162139, Free PMC Article
  3. Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS. Kim JB, et al. J Biol Chem, 2013 Apr 26. PMID 23479728, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • Kiaa0317, mKIAA0317

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K33-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
apoptosis-resistant E3 ubiquitin protein ligase 1
Names
apoptosis-resistant HECT-type E3 ubiquitin transferase 1
NP_001351118.1
NP_001351119.1
NP_835166.3
XP_006516254.1
XP_030102751.1
XP_030102752.1
XP_036013493.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364189.1 → NP_001351118.1  apoptosis-resistant E3 ubiquitin protein ligase 1

    Status: VALIDATED

    Source sequence(s)
    CR974585
    Consensus CDS
    CCDS26051.1
    UniProtKB/Swiss-Prot
    Q6P9Q1, Q80YC4, Q8C5W5, Q8CHG5
    UniProtKB/TrEMBL
    Q3U3Y1
    Conserved Domains (2) summary
    cd00078
    Location:464 → 821
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00630
    Location:56 → 154
    Filamin; Filamin/ABP280 repeat

  2. NM_001364190.1 → NP_001351119.1  apoptosis-resistant E3 ubiquitin protein ligase 1

    Status: VALIDATED

    Source sequence(s)
    AK077015, AK147491, CR974585
    Consensus CDS
    CCDS26051.1
    UniProtKB/Swiss-Prot
    Q6P9Q1, Q80YC4, Q8C5W5, Q8CHG5
    UniProtKB/TrEMBL
    Q3U3Y1
    Conserved Domains (2) summary
    cd00078
    Location:464 → 821
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00630
    Location:56 → 154
    Filamin; Filamin/ABP280 repeat

  3. NM_178065.5 → NP_835166.3  apoptosis-resistant E3 ubiquitin protein ligase 1

    See identical proteins and their annotated locations for NP_835166.3

    Status: VALIDATED

    Source sequence(s)
    AW045956, BC060658, BC079590, CJ128427
    Consensus CDS
    CCDS26051.1
    UniProtKB/Swiss-Prot
    Q6P9Q1, Q80YC4, Q8C5W5, Q8CHG5
    UniProtKB/TrEMBL
    Q3U3Y1
    Related
    ENSMUSP00000048780.8, ENSMUST00000043169.14
    Conserved Domains (2) summary
    cd00078
    Location:464 → 821
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00630
    Location:56 → 154
    Filamin; Filamin/ABP280 repeat

RNA

  1. NR_157097.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CR974585
    Related
    ENSMUST00000163231.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    84964914..85017674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516191.5 → XP_006516254.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2

    UniProtKB/TrEMBL
    Q3U3Y1
    Conserved Domains (2) summary
    cd00078
    Location:454 → 811
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00630
    Location:56 → 143
    Filamin; Filamin/ABP280 repeat

  2. XM_030246892.2 → XP_030102752.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2

    UniProtKB/TrEMBL
    Q3U3Y1
    Conserved Domains (2) summary
    cd00078
    Location:454 → 811
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00630
    Location:56 → 143
    Filamin; Filamin/ABP280 repeat

  3. XM_036157600.1 → XP_036013493.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6P9Q1, Q80YC4, Q8C5W5, Q8CHG5
    UniProtKB/TrEMBL
    Q3U3Y1
    Conserved Domains (2) summary
    cd00078
    Location:464 → 821
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00630
    Location:56 → 154
    Filamin; Filamin/ABP280 repeat

  4. XM_030246891.1 → XP_030102751.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6P9Q1, Q80YC4, Q8C5W5, Q8CHG5
    UniProtKB/TrEMBL
    Q3U3Y1
    Conserved Domains (2) summary
    cd00078
    Location:464 → 821
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00630
    Location:56 → 154
    Filamin; Filamin/ABP280 repeat

RNA

  1. XR_872717.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CHG5.2 GenPept UniProtKB/Swiss-Prot:Q8CHG5

Gene LinkOut

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