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Mrpl14 mitochondrial ribosomal protein L14 [ Mus musculus (house mouse) ]

Gene ID: 68463, updated on 5-Mar-2024

Summary

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Official Symbol
Mrpl14provided by MGI
Official Full Name
mitochondrial ribosomal protein L14provided by MGI
Primary source
MGI:MGI:1333864
See related
Ensembl:ENSMUSG00000023939 AllianceGenome:MGI:1333864
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rpml32; MRP-L32; 1110006I11Rik
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL14 (mitochondrial ribosomal protein L14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 36.7), stomach adult (RPKM 34.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 C; 17 22.59 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (45991689..46009421)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (45685722..45698495)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52283 Neighboring gene STARR-positive B cell enhancer ABC_E9955 Neighboring gene predicted gene, 25008 Neighboring gene STARR-positive B cell enhancer ABC_E10956 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45775877-45776144 Neighboring gene calpain 11 Neighboring gene transmembrane protein 63b Neighboring gene STARR-positive B cell enhancer ABC_E7534 Neighboring gene predicted gene, 35456 Neighboring gene RIKEN cDNA 1600014C23 gene Neighboring gene cDNA sequence BE949265

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death. Roth KA, et al. Proc Natl Acad Sci U S A, 2000 Jan 4. PMID 10618441, Free PMC Article
  2. Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. Goldschmidt-Reisin S, et al. J Biol Chem, 1998 Dec 25. PMID 9857009
  3. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
  4. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  5. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein uL14m
Names
39S ribosomal protein L14, mitochondrial
L14mt
MRP-L14
mitochondrial ribosomal protein L32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026732.3 → NP_081008.1  large ribosomal subunit protein uL14m precursor

    See identical proteins and their annotated locations for NP_081008.1

    Status: VALIDATED

    Source sequence(s)
    AI844611, AK050273, BY085715
    Consensus CDS
    CCDS28815.1
    UniProtKB/Swiss-Prot
    Q3UNL3, Q9D1I6
    Related
    ENSMUSP00000024734.8, ENSMUST00000024734.8
    Conserved Domains (1) summary
    cl00328
    Location:33 → 141
    Ribosomal_L14; Ribosomal protein L14p/L23e

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    45991689..46009421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524843.4 → XP_006524906.1  large ribosomal subunit protein uL14m isoform X1

    See identical proteins and their annotated locations for XP_006524906.1

    UniProtKB/Swiss-Prot
    Q3UNL3, Q9D1I6
    Conserved Domains (1) summary
    cl00328
    Location:33 → 141
    Ribosomal_L14; Ribosomal protein L14p/L23e

  2. XM_006524844.5 → XP_006524907.1  large ribosomal subunit protein uL14m isoform X1

    See identical proteins and their annotated locations for XP_006524907.1

    UniProtKB/Swiss-Prot
    Q3UNL3, Q9D1I6
    Conserved Domains (1) summary
    cl00328
    Location:33 → 141
    Ribosomal_L14; Ribosomal protein L14p/L23e

  3. XM_017317618.3 → XP_017173107.1  large ribosomal subunit protein uL14m isoform X2

    Conserved Domains (1) summary
    cl00328
    Location:2 → 108
    Ribosomal_L14; Ribosomal protein L14p/L23e
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D1I6.1 GenPept UniProtKB/Swiss-Prot:Q9D1I6

Gene LinkOut

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