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Ppp1r14a protein phosphatase 1, regulatory inhibitor subunit 14A [ Mus musculus (house mouse) ]

Gene ID: 68458, updated on 5-Mar-2024

Summary

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Official Symbol
Ppp1r14aprovided by MGI
Official Full Name
protein phosphatase 1, regulatory inhibitor subunit 14Aprovided by MGI
Primary source
MGI:MGI:1931139
See related
Ensembl:ENSMUSG00000037166 AllianceGenome:MGI:1931139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cpi17; CPI-17; 1110001M11Rik
Summary
Predicted to enable protein serine/threonine phosphatase inhibitor activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be located in cytoplasm. Is expressed in several structures, including cardiovascular system; embryo endoderm; gut; nervous system; and respiratory system. Orthologous to human PPP1R14A (protein phosphatase 1 regulatory inhibitor subunit 14A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 168.4), lung adult (RPKM 163.0) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B1; 7 16.94 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28988732..28992817)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29289320..29293390)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene serine protease inhibitor, Kunitz type 2 Neighboring gene predicted gene, 45977 Neighboring gene STARR-seq mESC enhancer starr_18467 Neighboring gene double PHD fingers 1 Neighboring gene signal-induced proliferation-associated 1 like 3 Neighboring gene STARR-seq mESC enhancer starr_18469 Neighboring gene STARR-seq mESC enhancer starr_18470 Neighboring gene STARR-seq mESC enhancer starr_18474 Neighboring gene STARR-seq mESC enhancer starr_18476 Neighboring gene RIKEN cDNA 4932431P20 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:30303585-30303694

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CPI-17-mediated contraction of vascular smooth muscle is essential for the development of hypertension in obese mice. Sun J, et al. J Genet Genomics, 2019 Mar 20. PMID 30948334
  2. The essential role of phospho-T38 CPI-17 in the maintenance of physiological blood pressure using genetically modified mice. Yang Q, et al. FASEB J, 2018 Apr. PMID 29229685
  3. Smooth muscle-selective CPI-17 expression increases vascular smooth muscle contraction and blood pressure. Su W, et al. Am J Physiol Heart Circ Physiol, 2013 Jul 1. PMID 23604714, Free PMC Article
  4. The contribution of protein kinase C and CPI-17 signaling pathways to hypercontractility in murine experimental colitis. Ihara E, et al. Neurogastroenterol Motil, 2012 Jan. PMID 22093175
  5. Actions downstream of cyclic GMP/protein kinase G can reverse protein kinase C-mediated phosphorylation of CPI-17 and Ca²⁺ sensitization in smooth muscle. Bonnevier J, et al. J Biol Chem, 2004 Jul 9. PMID 15123611

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. upregulation of CPI-17-mediated calcium-sensitized vasocontraction by obesity contributes to the development of obesity-related hypertension
    Title: CPI-17-mediated contraction of vascular smooth muscle is essential for the development of hypertension in obese mice.
  2. These data provide a novel mechanism of the transcriptional control of CPI-17 in vascular smooth muscle cells under inflammatory conditions. Mechanistically, 2 GC boxes were identified as TNF response element in the CPI-17 promoter and KLF4 was upregulated by TNF, competed with Sp1 for the binding to the GC boxes in the CPI-17 promoter, and repressed CPI-17 transcription through histone deacetylase.
    Title: Transcriptional Suppression of CPI-17 Gene Expression in Vascular Smooth Muscle Cells by Tumor Necrosis Factor, Krüppel-Like Factor 4, and Sp1 Is Associated with Lipopolysaccharide-Induced Vascular Hypocontractility, Hypotension, and Mortality.
  3. CPI-17 phosphorylation at T38 is essential for the maintenance of physiological blood pressure.
    Title: The essential role of phospho-T38 CPI-17 in the maintenance of physiological blood pressure using genetically modified mice.
  4. Enhanced vasorelaxation in early endotoxemia is mediated by redox signaling through PKG-1alpha but in later endotoxemia by myosin phosphatase isoform shifts enhancing sensitivity to NO/cGMP as well as smooth muscle atrophy.
    Title: Redox signaling and splicing dependent change in myosin phosphatase underlie early versus late changes in NO vasodilator reserve in a mouse LPS model of sepsis.
  5. The study characterized the CPI-17 promoter and identified binding sites for GATA-6 and nuclear factor kappa B (NF-kappaB).
    Title: GATA-6 and NF-κB activate CPI-17 gene transcription and regulate Ca2+ sensitization of smooth muscle contraction.
  6. a novel signaling cascade that links RhoA-mediated calcium sensitivity to MEF2-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK, PP1alpha, and CPI-17.
    Title: A novel RhoA/ROCK-CPI-17-MEF2C signaling pathway regulates vascular smooth muscle cell gene expression.
  7. Data suggest that CPI-17 and both conventional and novel PKC isozymes contribute to the phasic and tonic contractile components of BALB/c colonic circular smooth muscle.
    Title: The contribution of protein kinase C and CPI-17 signaling pathways to hypercontractility in murine experimental colitis.
  8. Organ-specific mechanisms involving MYPT1, M-RIP, and CPI-17 are critical to regulating basal LC20 phosphorylation in gastrointestinal smooth muscles.
    Title: Regulation of basal LC20 phosphorylation by MYPT1 and CPI-17 in murine gastric antrum, gastric fundus, and proximal colon smooth muscles.
  9. calcium-independent phospholipase A2beta has a role in high glucose-induced activation of RhoA, Rho kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals
    Title: Role of calcium-independent phospholipase A2beta in high glucose-induced activation of RhoA, Rho kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals.
  10. CPI-17 expression is reversibly controlled in response to the phenotype transition of smooth muscle cells that restricts the signal to differentiated smooth muscle cells and particular cell types.
    Title: Expression of CPI-17 in smooth muscle during embryonic development and in neointimal lesion formation.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 14A
Names
17 kDa PKC-potentiated inhibitory protein of PP1
protein kinase C-potentiated inhibitor protein of 17 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418823.1 → NP_001405752.1  protein phosphatase 1 regulatory subunit 14A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166079

  2. NM_001418824.1 → NP_001405753.1  protein phosphatase 1 regulatory subunit 14A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166079
    UniProtKB/TrEMBL
    A0A140LI58
    Related
    ENSMUSP00000146684.2, ENSMUST00000207714.2

  3. NM_001418825.1 → NP_001405754.1  protein phosphatase 1 regulatory subunit 14A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC166079

  4. NM_026731.4 → NP_081007.2  protein phosphatase 1 regulatory subunit 14A isoform 1

    See identical proteins and their annotated locations for NP_081007.2

    Status: VALIDATED

    Source sequence(s)
    AC166079
    Consensus CDS
    CCDS21070.1
    UniProtKB/Swiss-Prot
    Q91VC7, Q99MB9
    Related
    ENSMUSP00000035642.5, ENSMUST00000048187.6
    Conserved Domains (1) summary
    pfam05361
    Location:1 → 134
    PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28988732..28992817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VC7.1 GenPept UniProtKB/Swiss-Prot:Q91VC7

Gene LinkOut

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