Gpihbp1 GPI-anchored HDL-binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpihbp1provided by MGI
Official Full Name: GPI-anchored HDL-binding protein 1provided by MGI
Primary source: MGI:MGI:1915703
See related: Ensembl:ENSMUSG00000022579 AllianceGenome:MGI:1915703
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GPI-HBP1; 1110002J19Rik
Summary: Enables lipase binding activity; lipoprotein particle binding activity; and protein transporter activity. Involved in several processes, including lipid homeostasis; positive regulation of chylomicron remnant clearance; and protein transport. Acts upstream of or within lipid transport. Located in apical plasma membrane; basolateral plasma membrane; and external side of plasma membrane. Is anchored component of plasma membrane. Human ortholog(s) of this gene implicated in familial GPIHBP1 deficiency. Orthologous to human GPIHBP1 (glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 157.2), subcutaneous fat pad adult (RPKM 146.6) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 34.59 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (75468479..75470062)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (75596630..75598213)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AAV-mediated hepatic LPL expression ameliorates severe hypertriglyceridemia and acute pancreatitis in Gpihbp1 deficient mice and rats.
Title: AAV-mediated hepatic LPL expression ameliorates severe hypertriglyceridemia and acute pancreatitis in Gpihbp1 deficient mice and rats.
Severe hypertriglyceridemia caused by Gpihbp1 deficiency facilitates vascular remodeling through increasing endothelial activation and oxidative stress.
Title: Severe hypertriglyceridemia caused by Gpihbp1 deficiency facilitates vascular remodeling through increasing endothelial activation and oxidative stress.
GPIHBP1, a partner protein for lipoprotein lipase, is expressed only in capillary endothelial cells.
Title: GPIHBP1, a partner protein for lipoprotein lipase, is expressed only in capillary endothelial cells.
The reduced expression of GPIHBP1 was insufficient to prevent LPL from reaching the capillary lumen, and it did not lead to hypertriglyceridemia-even when mice were fed a high-fat diet.
Title: An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner.
Gpihbp1 deficiency accelerates the development of atherosclerosis in the aorta, and the instability of plaques in Ldlr knockout mice and diabetes promotes these pathologic processes with coronary atherosclerosis
Title: Gpihbp1 deficiency accelerates atherosclerosis and plaque instability in diabetic Ldlr(-/-) mice.
GPIHBP1 expression in gliomas facilitates triglyceride-rich lipoproteins processing and provides a source of lipid nutrients for glioma cells.
Title: GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients.
GPIHBP1-independent pathway for clearance of plasma TGs in Angptl4(-/-)Gpihbp1(-/-) mice
Title: Novel GPIHBP1-independent pathway for clearance of plasma TGs in Angptl4(-/-)Gpihbp1(-/-) mice.
we assessed visceral adipose tissue GPIHBP1 protein expression in type 2 diabetes Lepr db/db mouse model as well as in subjects with ranging levels of insulin resistance. We report that insulin reduces the expression of GPIHBP1 protein in HMVECs. Furthermore, GPIHBP1 protein expression in visceral adipose tissue in Lepr db/db mice is significantly reduced as is the active monomeric form of GPIHBP1 as compared to Leprdb/m
Title: Decreased GPIHBP1 protein levels in visceral adipose tissue partly underlie the hypertriglyceridemic phenotype in insulin resistance.
the negatively charged IDR of GPIHBP1 traverses a vast space, facilitating capture of LPL by capillary endothelial cells and simultaneously contributing to GPIHBP1's ability to preserve LPL structure and activity.
Title: A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase.
mutation of a conserved cysteine in GPIHBP1 abolishes the ability of GPIHBP1 to bind LPL
Title: Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylcholine receptor inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables chylomicron binding	IBA Inferred from Biological aspect of Ancestor more info
enables chylomicron binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables chylomicron binding	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle binding	IDA Inferred from Direct Assay more info	PubMed
enables lipase binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipase binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipase binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipoprotein lipase activator activity	ISO Inferred from Sequence Orthology more info
enables lipoprotein particle binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables protein transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within cholesterol transport	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular protein transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lipid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chylomicron remnant clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chylomicron remodeling	IC Inferred by Curator more info	PubMed
involved_in positive regulation of lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of lipoprotein lipase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lipoprotein lipase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lipoprotein lipase activity	ISO Inferred from Sequence Orthology more info
involved_in protein import	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to cell surface	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in response to heparin	ISO Inferred from Sequence Orthology more info
involved_in transcytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of catalytic complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Names: high density lipoprotein-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347039.2 → NP_001333968.1 glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC119264

Consensus CDS

CCDS84173.1

UniProtKB/TrEMBL

A0A087WNV7

Related

ENSMUSP00000139511.2, ENSMUST00000189944.7
NM_001361294.1 → NP_001348223.1 glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC119264, AK050431, BC061225

Consensus CDS

CCDS88781.1

UniProtKB/TrEMBL

A0A087WPI6

Related

ENSMUSP00000139792.2, ENSMUST00000189874.2

Conserved Domains (1) summary

cl10471
Location:61 → 106

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
NM_026730.2 → NP_081006.1 glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_081006.1

Status: VALIDATED

Source sequence(s)

AC119264, BC061225

Consensus CDS

CCDS27545.1

UniProtKB/Swiss-Prot

Q9D1N2

Related

ENSMUSP00000023243.5, ENSMUST00000023243.11

Conserved Domains (1) summary

cd00117
Location:61 → 138

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...