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Ankrd13a ankyrin repeat domain 13a [ Mus musculus (house mouse) ]

Gene ID: 68420, updated on 30-Apr-2024

Summary

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Official Symbol
Ankrd13aprovided by MGI
Official Full Name
ankyrin repeat domain 13aprovided by MGI
Primary source
MGI:MGI:1915670
See related
Ensembl:ENSMUSG00000041870 AllianceGenome:MGI:1915670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ANKRD13; 1100001D10Rik
Summary
Predicted to enable ubiquitin-dependent protein binding activity. Predicted to be involved in negative regulation of protein localization to endosome and negative regulation of receptor internalization. Predicted to be located in late endosome; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in acoustic ganglion; endolymphatic appendage; and otocyst. Orthologous to human ANKRD13A (ankyrin repeat domain 13A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 63.8), colon adult (RPKM 53.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 55.99 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (114913009..114943882)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114774948..114805821)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene trichoplein, keratin filament binding Neighboring gene microRNA 7028 Neighboring gene GIT ArfGAP 2 Neighboring gene RIKEN cDNA 4930515G01 gene Neighboring gene STARR-positive B cell enhancer ABC_E3602 Neighboring gene STARR-positive B cell enhancer ABC_E3603 Neighboring gene STARR-seq mESC enhancer starr_14089 Neighboring gene RIKEN cDNA 1500011B03 gene Neighboring gene RIKEN cDNA 2610524H06 gene Neighboring gene STARR-seq mESC enhancer starr_14090

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB. Won M, et al. Cell Death Differ, 2022 Jun. PMID 34839354, Free PMC Article
  2. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102
  3. Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. McLelland GL, et al. Elife, 2018 Apr 20. PMID 29676259, Free PMC Article
  4. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118502

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin-modified protein reader activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of protein localization to endosome ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 13A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378897.1 → NP_001365826.1  ankyrin repeat domain-containing protein 13A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087330
    UniProtKB/TrEMBL
    Q3U0V3
    Conserved Domains (3) summary
    sd00045
    Location:12 → 38
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:156 → 469
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:13 → 96
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_026718.2 → NP_080994.2  ankyrin repeat domain-containing protein 13A isoform 1

    See identical proteins and their annotated locations for NP_080994.2

    Status: VALIDATED

    Source sequence(s)
    BC061692
    Consensus CDS
    CCDS19572.1
    UniProtKB/Swiss-Prot
    Q2VPQ7, Q6P7F2, Q80UP5
    UniProtKB/TrEMBL
    Q3U0V3
    Related
    ENSMUSP00000099638.5, ENSMUST00000102578.11
    Conserved Domains (4) summary
    cd00204
    Location:4 → 101
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam11904
    Location:156 → 468
    GPCR_chapero_1; GPCR-chaperone
    pfam13637
    Location:41 → 90
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:12 → 38
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    114913009..114943882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80UP5.2 GenPept UniProtKB/Swiss-Prot:Q80UP5

Gene LinkOut

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