Nrn1 neuritin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nrn1provided by MGI
Official Full Name: neuritin 1provided by MGI
Primary source: MGI:MGI:1915654
See related: Ensembl:ENSMUSG00000039114 AllianceGenome:MGI:1915654
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nrn; Cpg15; 0710008J23Rik
Summary: Enables identical protein binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within neuron projection extension. Located in extracellular space. Is anchored component of plasma membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb mesenchyme; and liver. Orthologous to human NRN1 (neuritin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 84.3), cortex adult (RPKM 52.3) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A3.3; 13 14.44 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (36909596..36918451, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (36725622..36734477, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of Cpg15 Alleviates the Oxidative Stress in Neuronal Cells Via Regulating Redox Enzymes and Nrf2 Antioxidative Pathway.
Title: Overexpression of Cpg15 Alleviates the Oxidative Stress in Neuronal Cells Via Regulating Redox Enzymes and Nrf2 Antioxidative Pathway.
Neuritin improves the neurological functional recovery after experimental intracerebral hemorrhage in mice.
Title: Neuritin improves the neurological functional recovery after experimental intracerebral hemorrhage in mice.
Neuritin inhibits astrogliosis to ameliorate diabetic cognitive dysfunction.
Title: Neuritin inhibits astrogliosis to ameliorate diabetic cognitive dysfunction.
Ezh1 regulates expression of Cpg15/Neuritin in mouse cortical neurons.
Title: Ezh1 regulates expression of Cpg15/Neuritin in mouse cortical neurons.
Decreased cpg15 augments oxidative stress in sleep deprived mouse brain.
Title: Decreased cpg15 augments oxidative stress in sleep deprived mouse brain.
Optic nerve injury induced upregulation of neuritin mRNA in the retina of WT mice. Inner retinal degeneration following optic nerve injury was more severe in neuritin KO mice.
Title: Role of neuritin in retinal ganglion cell death in adult mice following optic nerve injury.
Following cerebral ischemia there is an increase in cpg15 expression in hippocampal astrocytes.
Title: Soluble cpg15 from Astrocytes Ameliorates Neurite Outgrowth Recovery of Hippocampal Neurons after Mouse Cerebral Ischemia.
Ca(2+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT) c4 axis is required for neuritin-induced Kv4.2 transcriptional expression and potentiation of IA densities in cerebellum granule neurons.
Title: Neuritin Up-regulates Kv4.2 α-Subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway.
Neuritin prevents extremely low-frequency electromagnetic fields-exposure-induced memory deficit by increasing the hippocampal spine density.
Title: Neuritin reverses deficits in murine novel object associative recognition memory caused by exposure to extremely low-frequency (50 Hz) electromagnetic fields.
Neuritin can normalize neural deficits of Alzheimer's disease.
Title: Neuritin can normalize neural deficits of Alzheimer's disease.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

Nrn1 (e-PCR), detects polymorphism
- UniSTS:531349

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info	PubMed
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron projection extension	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuritin

Names: candidate plasticity gene 15 protein; candidate plasticity-related gene 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.