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Lrriq4 leucine-rich repeats and IQ motif containing 4 [ Mus musculus (house mouse) ]

Gene ID: 68307, updated on 5-Mar-2024

Summary

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Official Symbol
Lrriq4provided by MGI
Official Full Name
leucine-rich repeats and IQ motif containing 4provided by MGI
Primary source
MGI:MGI:1915557
See related
Ensembl:ENSMUSG00000027703 AllianceGenome:MGI:1915557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930558O21Rik
Summary
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to human LRRIQ4 (leucine rich repeats and IQ motif containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 12.1) See more
Orthologs
human all
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Genomic context

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Location:
3 A3; 3 14.27 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (30698636..30726583)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (30644487..30672434)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2661 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:30500978-30501161 Neighboring gene nuclear encoded tRNA valine 8 (anticodon AAC) Neighboring gene myoneurin Neighboring gene leucine rich repeat containing 34 Neighboring gene STARR-seq mESC enhancer starr_07297 Neighboring gene STARR-seq mESC enhancer starr_07298 Neighboring gene STARR-seq mESC enhancer starr_07299 Neighboring gene leucine rich repeat containing 31 Neighboring gene predicted gene 15462 Neighboring gene STARR-seq mESC enhancer starr_07301 Neighboring gene sterile alpha motif domain containing 7 Neighboring gene predicted gene, 33590

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine-rich repeat and IQ domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290510.2 → NP_001277439.1  leucine-rich repeat and IQ domain-containing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001277439.1

    Status: VALIDATED

    Source sequence(s)
    AC120377
    Consensus CDS
    CCDS71229.1
    UniProtKB/TrEMBL
    Q9D2F4
    Related
    ENSMUSP00000103900.3, ENSMUST00000108265.3
    Conserved Domains (4) summary
    cd00116
    Location:221 → 382
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:257 → 279
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:420 → 459
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:420 → 477
    LRR_8; Leucine rich repeat

  2. NM_026668.3 → NP_080944.2  leucine-rich repeat and IQ domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_080944.2

    Status: VALIDATED

    Source sequence(s)
    AC120377
    Consensus CDS
    CCDS38406.1
    UniProtKB/Swiss-Prot
    A6H6A4, Q9D5Q5
    UniProtKB/TrEMBL
    Q9D2F4
    Related
    ENSMUSP00000103902.2, ENSMUST00000108267.8
    Conserved Domains (4) summary
    cd00116
    Location:236 → 397
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:272 → 294
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:435 → 474
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:435 → 492
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    30698636..30726583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249709.3 → XP_011248011.1  leucine-rich repeat and IQ domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    Q9D2F4
    Conserved Domains (4) summary
    smart00015
    Location:543 → 563
    IQ; Calmodulin-binding motif
    COG4886
    Location:228 → 521
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:275 → 297
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:48 → 309
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  2. XM_011249710.3 → XP_011248012.1  leucine-rich repeat and IQ domain-containing protein 4 isoform X2

    Conserved Domains (2) summary
    COG4886
    Location:169 → 414
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:206 → 228
    LRR_RI; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6H6A4.1 GenPept UniProtKB/Swiss-Prot:A6H6A4

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