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Aar2 AAR2 splicing factor homolog [ Mus musculus (house mouse) ]

Gene ID: 68295, updated on 5-Mar-2024

Summary

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Official Symbol
Aar2provided by MGI
Official Full Name
AAR2 splicing factor homologprovided by MGI
Primary source
MGI:MGI:1915545
See related
Ensembl:ENSMUSG00000027628 AllianceGenome:MGI:1915545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610011L14Rik
Summary
Predicted to be involved in spliceosomal tri-snRNP complex assembly. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be part of spliceosomal complex. Is expressed in gonad. Orthologous to human AAR2 (AAR2 splicing factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 10.4), ovary adult (RPKM 9.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H1; 2 77.54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156389496..156410892)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156547560..156568972)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37a pseudogene Neighboring gene erythrocyte membrane protein band 4.1 like 1 Neighboring gene STARR-seq mESC enhancer starr_06170 Neighboring gene STARR-seq mESC enhancer starr_06171 Neighboring gene predicted gene, 33977 Neighboring gene STARR-seq mESC enhancer starr_06172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156373177-156373360 Neighboring gene predicted gene 14169 Neighboring gene DLG associated protein 4 Neighboring gene predicted gene 14172

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A proteomics strategy for the enrichment of receptor-associated complexes. Cross M, et al. Proteomics, 2005 Dec. PMID 16267818
  2. Large-scale screen for genes involved in gonad development. Wertz K, et al. Mech Dev, 2000 Nov. PMID 11044607
  3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal tri-snRNP complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein AAR2 homolog
Names
novel transcript

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164818.1 → NP_001158290.1  protein AAR2 homolog

    See identical proteins and their annotated locations for NP_001158290.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK028890, AK169526, CJ152371
    Consensus CDS
    CCDS16967.1
    UniProtKB/Swiss-Prot
    Q3TEN8, Q3TM16, Q8VBU9, Q9D2V5
    UniProtKB/TrEMBL
    Q8C161
    Related
    ENSMUSP00000105198.2, ENSMUST00000109570.8
    Conserved Domains (1) summary
    pfam05282
    Location:17 → 363
    AAR2; AAR2 protein

  2. NM_026661.4 → NP_080937.3  protein AAR2 homolog

    See identical proteins and their annotated locations for NP_080937.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AK018741, AK028890, CJ152371
    Consensus CDS
    CCDS16967.1
    UniProtKB/Swiss-Prot
    Q3TEN8, Q3TM16, Q8VBU9, Q9D2V5
    UniProtKB/TrEMBL
    Q8C161
    Related
    ENSMUSP00000029158.4, ENSMUST00000029158.4
    Conserved Domains (1) summary
    pfam05282
    Location:17 → 363
    AAR2; AAR2 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    156389496..156410892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500097.5 → XP_006500160.1  protein AAR2 homolog isoform X1

    See identical proteins and their annotated locations for XP_006500160.1

    UniProtKB/Swiss-Prot
    Q3TEN8, Q3TM16, Q8VBU9, Q9D2V5
    UniProtKB/TrEMBL
    Q8C161
    Conserved Domains (1) summary
    pfam05282
    Location:17 → 363
    AAR2; AAR2 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2V5.3 GenPept UniProtKB/Swiss-Prot:Q9D2V5

Gene LinkOut

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