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Rbm28 RNA binding motif protein 28 [ Mus musculus (house mouse) ]

Gene ID: 68272, updated on 26-Mar-2024

Summary

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Official Symbol
Rbm28provided by MGI
Official Full Name
RNA binding motif protein 28provided by MGI
Primary source
MGI:MGI:2655711
See related
Ensembl:ENSMUSG00000029701 AllianceGenome:MGI:2655711
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810480G15Rik
Summary
Predicted to enable RNA binding activity. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleolus. Predicted to be part of spliceosomal complex. Is expressed in central nervous system and sensory organ. Human ortholog(s) of this gene implicated in alopecia, neurologic defects, and endocrinopathy syndrome. Orthologous to human RBM28 (RNA binding motif protein 28). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 20.2), CNS E18 (RPKM 15.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Rbm28 in Genome Data Viewer
Location:
6 A3.3; 6 12.33 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29123572..29164975, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29123573..29164724, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene Lep proximal promoter region Neighboring gene leptin Neighboring gene STARR-seq mESC enhancer starr_15433 Neighboring gene predicted gene, 25589 Neighboring gene STARR-positive B cell enhancer ABC_E3646 Neighboring gene proline-rich transmembrane protein 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29155327-29155436 Neighboring gene STARR-positive B cell enhancer ABC_E8096 Neighboring gene inosine monophosphate dehydrogenase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sox2-Evf2 lncRNA-mediated mechanisms of chromosome topological control in developing forebrain. Cajigas I, et al. Development, 2021 Mar 15. PMID 33593819, Free PMC Article
  2. The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially Organizes Megabase Distant Genes in the Developing Forebrain. Cajigas I, et al. Mol Cell, 2018 Sep 20. PMID 30146317, Free PMC Article
  3. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
  4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC12075, MGC38664

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA-binding protein 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133925.2 → NP_598686.2  RNA-binding protein 28

    See identical proteins and their annotated locations for NP_598686.2

    Status: VALIDATED

    Source sequence(s)
    AA212598, AK087628, AK161670, AK167050, AW123167
    Consensus CDS
    CCDS51733.1
    UniProtKB/Swiss-Prot
    E9QKF8, Q3U0K5, Q8BG25, Q8CGC6, Q8VEJ8, Q9CS22, Q9CSE6
    Related
    ENSMUSP00000007993.10, ENSMUST00000007993.16
    Conserved Domains (5) summary
    PTZ00108
    Location:563 → 740
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd12413
    Location:5 → 81
    RRM1_RBM28_like; RNA recognition motif 1 (RRM1) found in RNA-binding protein 28 (RBM28) and similar proteins
    cd12414
    Location:115 → 190
    RRM2_RBM28_like; RNA recognition motif 2 (RRM2) found in RNA-binding protein 28 (RBM28) and similar proteins
    cd12415
    Location:325 → 407
    RRM3_RBM28_like; RNA recognition motif 3 (RRM3) found in RNA-binding protein 28 (RBM28) and similar proteins
    cd12416
    Location:477 → 571
    RRM4_RBM28_like; RNA recognition motif 4 (RRM4) found in RNA-binding protein 28 (RBM28) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    29123572..29164975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152280.1 → XP_036008173.1  RNA-binding protein 28 isoform X1

    Conserved Domains (3) summary
    TIGR01628
    Location:82 → 330
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12416
    Location:104 → 198
    RRM4_RBM28_like; RNA recognition motif 4 (RRM4) found in RNA-binding protein 28 (RBM28) and similar proteins
    cl17169
    Location:2 → 34
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_030255573.2 → XP_030111433.1  RNA-binding protein 28 isoform X1

    Conserved Domains (3) summary
    TIGR01628
    Location:82 → 330
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12416
    Location:104 → 198
    RRM4_RBM28_like; RNA recognition motif 4 (RRM4) found in RNA-binding protein 28 (RBM28) and similar proteins
    cl17169
    Location:2 → 34
    RRM_SF; RNA recognition motif (RRM) superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_026650.1: Suppressed sequence

    Description
    NM_026650.1: This RefSeq was temporarily suppressed because the CDS was partial, and there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CGC6.4 GenPept UniProtKB/Swiss-Prot:Q8CGC6

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