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Zdhhc21 zinc finger, DHHC domain containing 21 [ Mus musculus (house mouse) ]

Gene ID: 68268, updated on 5-Mar-2024

Summary

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Official Symbol
Zdhhc21provided by MGI
Official Full Name
zinc finger, DHHC domain containing 21provided by MGI
Primary source
MGI:MGI:1915518
See related
Ensembl:ENSMUSG00000028403 AllianceGenome:MGI:1915518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
dep; DHHC21; 9130404H11Rik; D130004H04Rik
Summary
Enables protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including peptidyl-L-cysteine S-palmitoylation; regulation of establishment of endothelial barrier; and regulation of vascular associated smooth muscle contraction. Acts upstream of or within hair follicle development; protein palmitoylation; and sebaceous gland development. Predicted to be located in plasma membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in early conceptus; eye; inner cell mass; oocyte; and trunk somite. Orthologous to human ZDHHC21 (zinc finger DHHC-type palmitoyltransferase 21). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 3.3), CNS E18 (RPKM 3.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 39.4 cM; 4 C3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (82716975..82778892, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (82798738..82859897, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA histidine 10 (anticodon GTG) Neighboring gene predicted gene 11269 Neighboring gene STARR-seq mESC enhancer starr_10625 Neighboring gene STARR-seq mESC enhancer starr_10626 Neighboring gene VISTA enhancer mm56 Neighboring gene cerberus 1, DAN family BMP antagonist Neighboring gene Fras1 related extracellular matrix protein 1 Neighboring gene predicted gene, 33260

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ca2+-dependent protein acyltransferase DHHC21 controls activation of CD4+ T cells. Bieerkehazhi S, et al. J Cell Sci, 2022 Mar 1. PMID 34080635, Free PMC Article
  2. DHHC21 deficiency attenuates renal dysfunction during septic injury. Yang X, et al. Sci Rep, 2021 May 27. PMID 34045489, Free PMC Article
  3. Regulation of T cell receptor signaling by protein acyltransferase DHHC21. Fan Y, et al. Mol Biol Rep, 2020 Aug. PMID 32789573, Free PMC Article
  4. Targeting palmitoyl acyltransferase ZDHHC21 improves gut epithelial barrier dysfunction resulting from burn-induced systemic inflammation. Haines RJ, et al. Am J Physiol Gastrointest Liver Physiol, 2017 Dec 1. PMID 28838985, Free PMC Article
  5. The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics. Marin EP, et al. Arterioscler Thromb Vasc Biol, 2016 Feb. PMID 26715683, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DHHC21 deficiency attenuates renal dysfunction during septic injury.
    Title: DHHC21 deficiency attenuates renal dysfunction during septic injury.
  2. Ca2+-dependent protein acyltransferase DHHC21 controls activation of CD4+ T cells.
    Title: Ca2+-dependent protein acyltransferase DHHC21 controls activation of CD4+ T cells.
  3. Regulation of T cell receptor signaling by protein acyltransferase DHHC21.
    Title: Regulation of T cell receptor signaling by protein acyltransferase DHHC21.
  4. Results suggest an important role of ZDHHC21 in mediating gut hyperpermeability resulting from thermal injury.
    Title: Targeting palmitoyl acyltransferase ZDHHC21 improves gut epithelial barrier dysfunction resulting from burn-induced systemic inflammation.
  5. ZDHHC21 F233Delta diminishes the function of vascular alpha1 adrenergic receptors, leading to reduced vascular tone, which manifests in vivo as hypotension and tachycardia.
    Title: The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics.
  6. the Src-family kinase, Fyn, involved in keratinocyte differentiation, is a direct palmitoylation target of Zdhhc21 and is mislocalized in mutant follicles
    Title: Palmitoylation regulates epidermal homeostasis and hair follicle differentiation.
Submit: New GeneRIF Correction

Phenotypes

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Associated conditions

Description Tests
depilated
GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adrenergic receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hair follicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein palmitoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of establishment of endothelial barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of leukocyte adhesion to arterial endothelial cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of vascular associated smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sebaceous gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC21
Names
DHHC domain-containing cysteine-rich protein 21
DHHC-21
GABA-A receptor-associated membrane protein 3
probable palmitoyltransferase ZDHHC21
zinc finger DHHC domain-containing protein 21
NP_080923.2
XP_006538279.1
XP_011248395.1
XP_011248396.1
XP_036020274.1
XP_036020275.1
XP_036020276.1
XP_036020277.1
XP_036020278.1
XP_036020279.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026647.4 → NP_080923.2  palmitoyltransferase ZDHHC21

    See identical proteins and their annotated locations for NP_080923.2

    Status: VALIDATED

    Source sequence(s)
    AK020293, AL671005, BC043110, BP753906
    Consensus CDS
    CCDS18294.1
    UniProtKB/Swiss-Prot
    Q6EMK1, Q80XQ3, Q9D270
    Related
    ENSMUSP00000030110.9, ENSMUST00000030110.15
    Conserved Domains (1) summary
    pfam01529
    Location:92 → 217
    DHHC; DHHC palmitoyltransferase

RNA

  1. NR_149737.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671005, BC043110, BP753906, CJ102811

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    82716975..82778892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164381.1 → XP_036020274.1  palmitoyltransferase ZDHHC21 isoform X1

    UniProtKB/Swiss-Prot
    Q6EMK1, Q80XQ3, Q9D270
    Conserved Domains (1) summary
    pfam01529
    Location:92 → 217
    DHHC; DHHC palmitoyltransferase

  2. XM_036164383.1 → XP_036020276.1  palmitoyltransferase ZDHHC21 isoform X1

    UniProtKB/Swiss-Prot
    Q6EMK1, Q80XQ3, Q9D270
    Related
    ENSMUSP00000102859.2, ENSMUST00000107239.8
    Conserved Domains (1) summary
    pfam01529
    Location:92 → 217
    DHHC; DHHC palmitoyltransferase

  3. XM_011250094.4 → XP_011248396.1  palmitoyltransferase ZDHHC21 isoform X1

    See identical proteins and their annotated locations for XP_011248396.1

    UniProtKB/Swiss-Prot
    Q6EMK1, Q80XQ3, Q9D270
    Conserved Domains (1) summary
    pfam01529
    Location:92 → 217
    DHHC; DHHC palmitoyltransferase

  4. XM_036164382.1 → XP_036020275.1  palmitoyltransferase ZDHHC21 isoform X1

    UniProtKB/Swiss-Prot
    Q6EMK1, Q80XQ3, Q9D270
    Conserved Domains (1) summary
    pfam01529
    Location:92 → 217
    DHHC; DHHC palmitoyltransferase

  5. XM_006538216.4 → XP_006538279.1  palmitoyltransferase ZDHHC21 isoform X1

    See identical proteins and their annotated locations for XP_006538279.1

    UniProtKB/Swiss-Prot
    Q6EMK1, Q80XQ3, Q9D270
    Conserved Domains (1) summary
    pfam01529
    Location:92 → 217
    DHHC; DHHC palmitoyltransferase

  6. XM_036164386.1 → XP_036020279.1  palmitoyltransferase ZDHHC21 isoform X2

    Conserved Domains (1) summary
    pfam01529
    Location:2 → 120
    DHHC; DHHC palmitoyltransferase

  7. XM_011250093.4 → XP_011248395.1  palmitoyltransferase ZDHHC21 isoform X1

    See identical proteins and their annotated locations for XP_011248395.1

    UniProtKB/Swiss-Prot
    Q6EMK1, Q80XQ3, Q9D270
    Conserved Domains (1) summary
    pfam01529
    Location:92 → 217
    DHHC; DHHC palmitoyltransferase

  8. XM_036164385.1 → XP_036020278.1  palmitoyltransferase ZDHHC21 isoform X1

    UniProtKB/Swiss-Prot
    Q6EMK1, Q80XQ3, Q9D270
    Conserved Domains (1) summary
    pfam01529
    Location:92 → 217
    DHHC; DHHC palmitoyltransferase

  9. XM_036164384.1 → XP_036020277.1  palmitoyltransferase ZDHHC21 isoform X1

    UniProtKB/Swiss-Prot
    Q6EMK1, Q80XQ3, Q9D270
    Conserved Domains (1) summary
    pfam01529
    Location:92 → 217
    DHHC; DHHC palmitoyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D270.2 GenPept UniProtKB/Swiss-Prot:Q9D270

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