U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc25a22 solute carrier family 25 (mitochondrial carrier, glutamate), member 22 [ Mus musculus (house mouse) ]

Gene ID: 68267, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Slc25a22provided by MGI
Official Full Name
solute carrier family 25 (mitochondrial carrier, glutamate), member 22provided by MGI
Primary source
MGI:MGI:1915517
See related
Ensembl:ENSMUSG00000019082 AllianceGenome:MGI:1915517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gc1; 1300006L01Rik
Summary
Predicted to enable L-aspartate transmembrane transporter activity and L-glutamate transmembrane transporter activity. Predicted to be involved in L-glutamate transmembrane transport; aspartate transmembrane transport; and malate-aspartate shuttle. Located in mitochondrion. Is expressed in alimentary system; eye; liver; and nervous system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 3. Orthologous to human SLC25A22 (solute carrier family 25 member 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 89.8), duodenum adult (RPKM 85.7) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7 F5; 7 86.78 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141009662..141017787, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141429749..141437874, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene glutamine amidotransferase like class 1 domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3761 Neighboring gene cell cycle exit and neuronal differentiation 1 Neighboring gene STARR-positive B cell enhancer ABC_E4986 Neighboring gene p53 induced death domain protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1097 Neighboring gene ribosomal protein lateral stalk subunit P2 Neighboring gene small nucleolar RNA, H/ACA box 52

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance. Wong CC, et al. Gastroenterology, 2020 Dec. PMID 32814111
  2. Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion. Casimir M, et al. J Biol Chem, 2009 Sep 11. PMID 19584051, Free PMC Article
  3. Transposon vectors for gene-trap insertional mutagenesis in vertebrates. Clark KJ, et al. Genesis, 2004 Aug. PMID 15286994
  4. Transposon mutagenesis of the mouse germline. Carlson CM, et al. Genetics, 2003 Sep. PMID 14504232, Free PMC Article
  5. The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters. Aleidi SM, et al. J Biol Chem, 2015 Oct 2. PMID 26296893, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance.
    Title: In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-aspartate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-glutamate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables amino acid:proton symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-glutamate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-glutamate transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in aspartate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in malate-aspartate shuttle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
mitochondrial glutamate carrier 1
Names
glutamate/H(+) symporter 1
solute carrier family 25 member 22

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177576.1 → NP_001171047.1  mitochondrial glutamate carrier 1 isoform a

    See identical proteins and their annotated locations for NP_001171047.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AK010193, AK162400, BC050887, BY296753
    Consensus CDS
    CCDS22013.1
    UniProtKB/Swiss-Prot
    Q3TRY1, Q9D6M3
    Related
    ENSMUSP00000101629.4, ENSMUST00000106007.10
    Conserved Domains (2) summary
    PTZ00169
    Location:3 → 289
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:6 → 96
    Mito_carr; Mitochondrial carrier protein

  2. NM_001360723.1 → NP_001347652.1  mitochondrial glutamate carrier 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC158224
    Consensus CDS
    CCDS22013.1
    UniProtKB/Swiss-Prot
    Q3TRY1, Q9D6M3
    Conserved Domains (2) summary
    PTZ00169
    Location:3 → 289
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:6 → 96
    Mito_carr; Mitochondrial carrier protein

  3. NM_001360724.1 → NP_001347653.1  mitochondrial glutamate carrier 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC158224
    Related
    ENSMUST00000140602.8
    Conserved Domains (1) summary
    pfam00153
    Location:19 → 128
    Mito_carr; Mitochondrial carrier protein

  4. NM_026646.3 → NP_080922.1  mitochondrial glutamate carrier 1 isoform a

    See identical proteins and their annotated locations for NP_080922.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC158224, AK010193, BC050887
    Consensus CDS
    CCDS22013.1
    UniProtKB/Swiss-Prot
    Q3TRY1, Q9D6M3
    Related
    ENSMUSP00000019226.8, ENSMUST00000019226.14
    Conserved Domains (2) summary
    PTZ00169
    Location:3 → 289
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:6 → 96
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141009662..141017787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242948.1 → XP_030098808.1  mitochondrial glutamate carrier 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3TRY1, Q9D6M3
    Conserved Domains (2) summary
    PTZ00169
    Location:3 → 289
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:6 → 96
    Mito_carr; Mitochondrial carrier protein

  2. XM_030242950.1 → XP_030098810.1  mitochondrial glutamate carrier 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3TRY1, Q9D6M3
    Conserved Domains (2) summary
    PTZ00169
    Location:3 → 289
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:6 → 96
    Mito_carr; Mitochondrial carrier protein

  3. XM_030242949.2 → XP_030098809.1  mitochondrial glutamate carrier 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3TRY1, Q9D6M3
    Conserved Domains (2) summary
    PTZ00169
    Location:3 → 289
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:6 → 96
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D6M3.1 GenPept UniProtKB/Swiss-Prot:Q9D6M3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous