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Tmem86b transmembrane protein 86B [ Mus musculus (house mouse) ]

Gene ID: 68255, updated on 11-Apr-2024

Summary

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Official Symbol
Tmem86bprovided by MGI
Official Full Name
transmembrane protein 86Bprovided by MGI
Primary source
MGI:MGI:1915505
See related
Ensembl:ENSMUSG00000045282 AllianceGenome:MGI:1915505
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C330014O21Rik
Summary
Predicted to enable alkenylglycerophosphocholine hydrolase activity; alkenylglycerophosphoethanolamine hydrolase activity; and identical protein binding activity. Predicted to be involved in ether lipid metabolic process. Predicted to be located in cytoplasm and membrane. Is expressed in several structures, including brain; genitourinary system; gut gland; thymus; and trachea. Orthologous to human TMEM86B (transmembrane protein 86B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 95.9), duodenum adult (RPKM 74.9) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A1; 7 2.67 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4631039..4634211, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4628040..4631404, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene hematological and neurological expressed 1-like pseudogene Neighboring gene predicted gene 9463 Neighboring gene protein phosphatase 6, regulatory subunit 1 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:4605526-4605679 Neighboring gene STARR-positive B cell enhancer ABC_E3695 Neighboring gene HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 Neighboring gene STARR-positive B cell enhancer ABC_E2219

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptional inhibition of the murine erythropoietin receptor gene by an upstream repetitive element. Youssoufian H, et al. Mol Cell Biol, 1993 Jan. PMID 8417366, Free PMC Article
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC118389

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-lysine 5,6-aminomutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-lysine 5,6-aminomutase activity ISO
Inferred from Sequence Orthology
more info
  
enables alkenylglycerophosphocholine hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alkenylglycerophosphocholine hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ether lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ether lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lysoplasmalogenase TMEM86B
Names
lysoplasmalogenase
NP_075929.1
XP_011248988.1
XP_011248989.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023440.3 → NP_075929.1  lysoplasmalogenase TMEM86B

    See identical proteins and their annotated locations for NP_075929.1

    Status: VALIDATED

    Source sequence(s)
    AC161197
    Consensus CDS
    CCDS20739.1
    UniProtKB/Swiss-Prot
    Q497J1
    UniProtKB/TrEMBL
    A0A0U1RQ11
    Related
    ENSMUSP00000060237.7, ENSMUST00000055085.8
    Conserved Domains (1) summary
    pfam07947
    Location:47 → 217
    YhhN; YhhN-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4631039..4634211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250687.3 → XP_011248989.1  lysoplasmalogenase TMEM86B isoform X2

    UniProtKB/TrEMBL
    A0A0U1RQ11
    Conserved Domains (1) summary
    pfam07947
    Location:53 → 222
    YhhN; YhhN family

  2. XM_011250686.3 → XP_011248988.1  lysoplasmalogenase TMEM86B isoform X1

    UniProtKB/TrEMBL
    A0A0U1RQ11
    Conserved Domains (1) summary
    pfam07947
    Location:75 → 244
    YhhN; YhhN family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q497J1.1 GenPept UniProtKB/Swiss-Prot:Q497J1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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