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Mturn maturin, neural progenitor differentiation regulator homolog (Xenopus) [ Mus musculus (house mouse) ]

Gene ID: 68235, updated on 5-Mar-2024

Summary

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Official Symbol
Mturnprovided by MGI
Official Full Name
maturin, neural progenitor differentiation regulator homolog (Xenopus)provided by MGI
Primary source
MGI:MGI:1915485
See related
Ensembl:ENSMUSG00000038065 AllianceGenome:MGI:1915485
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410066E13Rik; B230212L03Rik
Summary
Involved in positive regulation of megakaryocyte differentiation. Predicted to be located in cytoplasm. Is expressed in several structures, including central nervous system; ileum; male reproductive gland or organ; notochord; and retina. Orthologous to human MTURN (maturin, neural progenitor differentiation regulator homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 30.4), CNS E14 (RPKM 17.3) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B3; 6 27.07 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (54658609..54680840)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (54681624..54703855)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene FK506 binding protein 14 Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 Neighboring gene STARR-seq mESC enhancer starr_15954 Neighboring gene predicted gene, 34249 Neighboring gene STARR-seq mESC enhancer starr_15956 Neighboring gene STARR-seq mESC enhancer starr_15957 Neighboring gene predicted gene, 44008 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:54760023-54760206 Neighboring gene STARR-positive B cell enhancer ABC_E10381 Neighboring gene zinc and ring finger 2 Neighboring gene STARR-seq mESC enhancer starr_15969 Neighboring gene nucleotide-binding oligomerization domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. C-Jun/C7ORF41/NF-κB axis mediates hepatic inflammation and lipid accumulation in NAFLD. Yan FJ, et al. Biochem J, 2020 Feb 14. PMID 31957809
  2. C7ORF41 Regulates Inflammation by Inhibiting NF-κB Signaling Pathway. Zhou J, et al. Biomed Res Int, 2021. PMID 33506033, Free PMC Article
  3. Novel function of the chromosome 7 open reading frame 41 gene to promote leukemic megakaryocyte differentiation by modulating TPA-induced signaling. Sun X, et al. Blood Cancer J, 2014 Mar 28. PMID 24681962, Free PMC Article
  4. Maturin is a novel protein required for differentiation during primary neurogenesis. Martinez-De Luna RI, et al. Dev Biol, 2013 Dec 1. PMID 24095902, Free PMC Article
  5. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron development ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of megakaryocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of megakaryocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
maturin
Names
UPF0452 protein C7orf41 homolog
maturin neural progenitor differentiation regulator protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289740.1 → NP_001276669.1  maturin isoform a

    See identical proteins and their annotated locations for NP_001276669.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (a).
    Source sequence(s)
    AC084800, BC052467, BY266709
    Consensus CDS
    CCDS20158.2
    UniProtKB/Swiss-Prot
    Q8CGA4
    Related
    ENSMUSP00000140586.2, ENSMUST00000190641.7
    Conserved Domains (1) summary
    pfam15167
    Location:4 → 131
    DUF4581; Domain of unknown function (DUF4581)

  2. NM_001289741.1 → NP_001276670.1  maturin isoform b

    See identical proteins and their annotated locations for NP_001276670.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 3' exon structure, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is longer than isoform a.
    Source sequence(s)
    AC084800, BC052467, BY266709
    Consensus CDS
    CCDS80537.1
    UniProtKB/TrEMBL
    A0A087WQV4
    Related
    ENSMUSP00000140358.2, ENSMUST00000187701.2
    Conserved Domains (1) summary
    pfam15167
    Location:4 → 129
    DUF4581; Domain of unknown function (DUF4581)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    54658609..54680840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241447.3 → XP_011239749.1  maturin isoform X1

    See identical proteins and their annotated locations for XP_011239749.1

    UniProtKB/TrEMBL
    A0A087WQV4
    Conserved Domains (1) summary
    pfam15167
    Location:4 → 129
    DUF4581; Domain of unknown function (DUF4581)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_026629.3: Suppressed sequence

    Description
    NM_026629.3: This RefSeq was permanently suppressed because currently there is insufficient support for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CGA4.1 GenPept UniProtKB/Swiss-Prot:Q8CGA4

Gene LinkOut

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