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H2al2a H2A histone family member L2A [ Mus musculus (house mouse) ]

Gene ID: 68231, updated on 4-Jan-2025

Summary

Official Symbol
H2al2aprovided by MGI
Official Full Name
H2A histone family member L2Aprovided by MGI
Primary source
MGI:MGI:1915481
See related
Ensembl:ENSMUSG00000062651 AllianceGenome:MGI:1915481
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H2ab1; H2al2; Tseg1; H2afb1; TSEG-1; H2A.Bbd; H2A.L.2; 1700113O17Rik
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]
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Genomic context

See H2al2a in Genome Data Viewer
Location:
2 A3; 2 12.81 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (18001228..18001769, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (17996417..17996958, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene nebulette Neighboring gene STARR-seq mESC enhancer starr_03772 Neighboring gene STARR-seq mESC enhancer starr_03773 Neighboring gene microRNA 6419 Neighboring gene STARR-seq mESC enhancer starr_03774 Neighboring gene STARR-seq mESC enhancer starr_03776 Neighboring gene STARR-seq mESC enhancer starr_03777 Neighboring gene predicted gene 13323 Neighboring gene STARR-seq mESC enhancer starr_03784 Neighboring gene STARR-seq mESC enhancer starr_03791 Neighboring gene STARR-seq mESC enhancer starr_03792 Neighboring gene STARR-seq mESC enhancer starr_03793 Neighboring gene RIKEN cDNA A930004D18 gene Neighboring gene STARR-seq mESC enhancer starr_03796 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:17949221-17949330 Neighboring gene predicted gene, 33085 Neighboring gene predicted gene, 17762 Neighboring gene SKI/DACH domain containing 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding  
enables histone binding PubMed 
enables protein binding PubMed 
enables protein heterodimerization activity  
enables structural constituent of chromatin  
enables structural constituent of chromatin  
Component Evidence Code Pubs
part_of nucleosome  
part_of nucleosome PubMed 
part_of nucleosome  
is_active_in nucleus  
located_in nucleus PubMed 
located_in pericentric heterochromatin PubMed 

General protein information

Preferred Names
histone H2A-Bbd type 1
Names
H2A Barr body-deficient
H2A histone family, member B1
histone H2A-like 2
histone H2Alike 2
histone variant H2al2
testis-specific expressed gene 1 protein
testis-specific expressed protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026627.2NP_080903.1  histone H2A-Bbd type 1

    See identical proteins and their annotated locations for NP_080903.1

    Status: REVIEWED

    Source sequence(s)
    AL928589
    Consensus CDS
    CCDS38050.1
    UniProtKB/Swiss-Prot
    Q9CQ70, Q9D9Q5
    Related
    ENSMUSP00000100618.3, ENSMUST00000105001.4
    Conserved Domains (1) summary
    cl23907
    Location:1399
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    18001228..18001769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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