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Spindoc spindlin interactor and repressor of chromatin binding [ Mus musculus (house mouse) ]

Gene ID: 68229, updated on 5-Mar-2024

Summary

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Official Symbol
Spindocprovided by MGI
Official Full Name
spindlin interactor and repressor of chromatin bindingprovided by MGI
Primary source
MGI:MGI:2147611
See related
Ensembl:ENSMUSG00000024970 AllianceGenome:MGI:2147611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SPIN-DOC; 1700105P06Rik
Summary
Involved in negative regulation of transcription, DNA-templated. Orthologous to human SPINDOC (spindlin interactor and repressor of chromatin binding). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 16.5), thymus adult (RPKM 10.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 5.32 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7333828..7364491, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7356463..7384302, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene REST corepressor 2 Neighboring gene MAP/microtubule affinity regulating kinase 2 Neighboring gene predicted gene 17227 Neighboring gene STARR-seq mESC enhancer starr_45463 Neighboring gene STARR-seq mESC enhancer starr_45464 Neighboring gene STARR-seq mESC enhancer starr_45465 Neighboring gene RIKEN cDNA 1700105P06 gene Neighboring gene STARR-positive B cell enhancer ABC_E3240 Neighboring gene RAB11B, member RAS oncogene family, pseudogene 2 Neighboring gene predicted gene, 18842

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Spin1 interactor, Spindoc, is dispensable for meiotic division, but essential for haploid spermatid development in mice. Jiang X, et al. Reprod Biol Endocrinol, 2021 Sep 15. PMID 34526015, Free PMC Article
  2. SPINDOC binds PARP1 to facilitate PARylation. Yang F, et al. Nat Commun, 2021 Nov 4. PMID 34737271, Free PMC Article
  3. A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1. Bae N, et al. J Biol Chem, 2017 Dec 22. PMID 29061846, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Spin1 interactor, Spindoc, is dispensable for meiotic division, but essential for haploid spermatid development in mice.
    Title: The Spin1 interactor, Spindoc, is dispensable for meiotic division, but essential for haploid spermatid development in mice.
  2. SPINDOC binds PARP1 to facilitate PARylation.
    Title: SPINDOC binds PARP1 to facilitate PARylation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein ADP-ribosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
spindlin interactor and repressor of chromatin-binding protein
Names
SPIN1-docking protein
uncharacterized protein C11orf84 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033139.4 → NP_001028311.2  spindlin interactor and repressor of chromatin-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001028311.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC129188
    Consensus CDS
    CCDS29523.1
    UniProtKB/Swiss-Prot
    Q05AH6, Q3TI49, Q3TQH2
    Related
    ENSMUSP00000025924.3, ENSMUST00000025924.4

  2. NM_001167831.2 → NP_001161303.1  spindlin interactor and repressor of chromatin-binding protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC129188
    UniProtKB/TrEMBL
    A0A494BBB2
    Related
    ENSMUST00000236817.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    7333828..7364491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251065.2 → XP_030106925.1  spindlin interactor and repressor of chromatin-binding protein isoform X3

    Conserved Domains (1) summary
    pfam18658
    Location:71 → 135
    zf-C2H2_12; Zinc-finger C2H2-type

  2. XM_011247332.4 → XP_011245634.1  spindlin interactor and repressor of chromatin-binding protein isoform X2

    Conserved Domains (1) summary
    pfam18658
    Location:110 → 174
    zf-C2H2_12; Zinc-finger C2H2-type

  3. XM_011247331.4 → XP_011245633.1  spindlin interactor and repressor of chromatin-binding protein isoform X1

    Conserved Domains (1) summary
    pfam18658
    Location:110 → 174
    zf-C2H2_12; Zinc-finger C2H2-type

RNA

  1. XR_003952811.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05AH6.1 GenPept UniProtKB/Swiss-Prot:Q05AH6

Gene LinkOut

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