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Fam98b family with sequence similarity 98, member B [ Mus musculus (house mouse) ]

Gene ID: 68215, updated on 5-Mar-2024

Summary

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Official Symbol
Fam98bprovided by MGI
Official Full Name
family with sequence similarity 98, member Bprovided by MGI
Primary source
MGI:MGI:1915465
See related
Ensembl:ENSMUSG00000027349 AllianceGenome:MGI:1915465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610510H03Rik
Summary
Predicted to enable identical protein binding activity and protein methyltransferase activity. Predicted to be involved in positive regulation of cell population proliferation; positive regulation of gene expression; and protein methylation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of tRNA-splicing ligase complex. Is expressed in cerebral cortex ventricular layer. Orthologous to human FAM98B (family with sequence similarity 98 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 18.3), CNS E14 (RPKM 16.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Fam98b in Genome Data Viewer
Location:
2 E5; 2 59.15 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (117080150..117102021)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (117249713..117271540)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RAS related protein 1a, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E2635 Neighboring gene predicted gene, 25189 Neighboring gene RAS guanyl releasing protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr2:117129704-117130005 Neighboring gene STARR-seq mESC enhancer starr_05451 Neighboring gene STARR-positive B cell enhancer ABC_E3392 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:117168575-117168758 Neighboring gene predicted gene, 32020

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin. Zhou X, et al. J Cell Biol, 2015 Sep 14. PMID 26370502, Free PMC Article
  2. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  3. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  4. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  5. The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3. Sánchez-Bellver L, et al. Int J Mol Sci, 2022 Oct 19. PMID 36293380, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA-Gm9866 promotes liver fibrosis by activating TGFbeta/Smad signaling via targeting Fam98b.
    Title: LncRNA-Gm9866 promotes liver fibrosis by activating TGFβ/Smad signaling via targeting Fam98b.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in protein methylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of tRNA-splicing ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tRNA-splicing ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein FAM98B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026620.3 → NP_080896.2  protein FAM98B

    See identical proteins and their annotated locations for NP_080896.2

    Status: VALIDATED

    Source sequence(s)
    AK019190, AL928959
    Consensus CDS
    CCDS16571.1
    UniProtKB/Swiss-Prot
    A2ATZ4, Q80VD1, Q9CS28, Q9CS37
    Related
    ENSMUSP00000028825.5, ENSMUST00000028825.5
    Conserved Domains (1) summary
    pfam10239
    Location:17 → 330
    DUF2465; Protein of unknown function (DUF2465)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    117080150..117102021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500096.5 → XP_006500159.1  protein FAM98B isoform X1

    Conserved Domains (1) summary
    pfam10239
    Location:17 → 303
    DUF2465; Protein of unknown function (DUF2465)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80VD1.1 GenPept UniProtKB/Swiss-Prot:Q80VD1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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