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Fam135a family with sequence similarity 135, member A [ Mus musculus (house mouse) ]

Gene ID: 68187, updated on 3-Apr-2024

Summary

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Official Symbol
Fam135aprovided by MGI
Official Full Name
family with sequence similarity 135, member Aprovided by MGI
Primary source
MGI:MGI:1915437
See related
Ensembl:ENSMUSG00000026153 AllianceGenome:MGI:1915437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921533L14Rik
Summary
Predicted to be involved in cellular lipid metabolic process. Is expressed in neural retinal epithelium; peripheral nervous system; retina layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human FAM135A (family with sequence similarity 135 member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 8.2), limb E14.5 (RPKM 7.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 A5; 1 9.87 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (24049824..24139444, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (24010758..24100484, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene beta-1,3-glucuronyltransferase 2 Neighboring gene small ArfGAP 1 Neighboring gene STARR-positive B cell enhancer ABC_E981 Neighboring gene predicted gene 53062 Neighboring gene succinate dehydrogenase complex assembly factor 4 Neighboring gene STARR-seq mESC enhancer starr_00443 Neighboring gene STARR-seq mESC enhancer starr_00445 Neighboring gene predicted gene, 30756 Neighboring gene STARR-seq mESC enhancer starr_00447 Neighboring gene collagen, type IX, alpha 1 Neighboring gene collagen, type XIX, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_00448 Neighboring gene STARR-seq mESC enhancer starr_00450 Neighboring gene STARR-seq mESC enhancer starr_00451 Neighboring gene predicted gene, 26418

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  2. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • KIAA1411

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cellular lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
protein FAM135A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403087.1 → NP_001390016.1  protein FAM135A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325

  2. NM_001403088.1 → NP_001390017.1  protein FAM135A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325

  3. NM_001403089.1 → NP_001390018.1  protein FAM135A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325

  4. NM_001403090.1 → NP_001390019.1  protein FAM135A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325
    UniProtKB/Swiss-Prot
    Q3UEW1, Q5XK31, Q6NS59, Q8BXS8, Q8BZL9, Q8K2K2, Q9D2J6
    Conserved Domains (2) summary
    pfam05057
    Location:1235 → 1430
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 172
    DUF3657; Protein FAM135

  5. NM_001403091.1 → NP_001390020.1  protein FAM135A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325

  6. NM_001403092.1 → NP_001390021.1  protein FAM135A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325
    Related
    ENSMUSP00000139633.2, ENSMUST00000187752.7

  7. NM_001403093.1 → NP_001390022.1  protein FAM135A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325

  8. NM_001403094.1 → NP_001390023.1  protein FAM135A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325
    UniProtKB/TrEMBL
    A0A087WRT5

  9. NM_001403095.1 → NP_001390024.1  protein FAM135A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325
    UniProtKB/TrEMBL
    A0A087WRT5
    Related
    ENSMUSP00000140766.2, ENSMUST00000187369.7

  10. NM_001403096.1 → NP_001390025.1  protein FAM135A isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325

  11. NM_001403097.1 → NP_001390026.1  protein FAM135A isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325

  12. NM_026604.4 → NP_080880.4  protein FAM135A isoform 3

    See identical proteins and their annotated locations for NP_080880.4

    Status: VALIDATED

    Source sequence(s)
    AK034175, AK044359, BC070446, BM200880, BY732479
    Consensus CDS
    CCDS14853.1
    UniProtKB/Swiss-Prot
    Q3UEW1, Q5XK31, Q6NS59, Q8BXS8, Q8BZL9, Q8K2K2, Q9D2J6
    UniProtKB/TrEMBL
    A0A087WP54
    Related
    ENSMUSP00000027337.9, ENSMUST00000027337.15
    Conserved Domains (2) summary
    pfam05057
    Location:1235 → 1430
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111 → 172
    DUF3657; Protein FAM135

RNA

  1. NR_175350.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    24049824..24139444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238569.3 → XP_011236871.1  protein FAM135A isoform X14

    Conserved Domains (1) summary
    pfam05057
    Location:645 → 840
    DUF676; Putative serine esterase (DUF676)

  2. XM_030242598.2 → XP_030098458.1  protein FAM135A isoform X11

    Conserved Domains (1) summary
    pfam05057
    Location:841 → 1036
    DUF676; Putative serine esterase (DUF676)

  3. XM_006496232.5 → XP_006496295.1  protein FAM135A isoform X2

    UniProtKB/TrEMBL
    A0A087WP54
    Conserved Domains (2) summary
    pfam05057
    Location:1239 → 1434
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:115 → 175
    DUF3657; Protein FAM135

  4. XM_017322275.3 → XP_017177764.1  protein FAM135A isoform X6

    UniProtKB/TrEMBL
    A0A087WP54
    Conserved Domains (2) summary
    pfam05057
    Location:1043 → 1238
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:115 → 175
    DUF3657; Protein FAM135

  5. XM_030242599.2 → XP_030098459.1  protein FAM135A isoform X12

    Conserved Domains (1) summary
    pfam05057
    Location:810 → 1005
    DUF676; Putative serine esterase (DUF676)

  6. XM_036153271.1 → XP_036009164.1  protein FAM135A isoform X10

    Conserved Domains (1) summary
    pfam05057
    Location:861 → 1056
    DUF676; Putative serine esterase (DUF676)

  7. XM_030242596.2 → XP_030098456.1  protein FAM135A isoform X10

    Conserved Domains (1) summary
    pfam05057
    Location:861 → 1056
    DUF676; Putative serine esterase (DUF676)

  8. XM_030242600.2 → XP_030098460.1  protein FAM135A isoform X12

    Conserved Domains (1) summary
    pfam05057
    Location:810 → 1005
    DUF676; Putative serine esterase (DUF676)

  9. XM_030242597.1 → XP_030098457.1  protein FAM135A isoform X10

    Conserved Domains (1) summary
    pfam05057
    Location:861 → 1056
    DUF676; Putative serine esterase (DUF676)

RNA

  1. XR_004934154.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NS59.2 GenPept UniProtKB/Swiss-Prot:Q6NS59

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