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SULT1A1 sulfotransferase family 1A member 1 [ Homo sapiens (human) ]

Gene ID: 6817, updated on 3-Apr-2024

Summary

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Official Symbol
SULT1A1provided by HGNC
Official Full Name
sulfotransferase family 1A member 1provided by HGNC
Primary source
HGNC:HGNC:11453
See related
Ensembl:ENSG00000196502 MIM:171150; AllianceGenome:HGNC:11453
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PST; STP; STP1; P-PST; ST1A1; ST1A3; TSPST1; ts-PST; P-PST 1; HAST1/HAST2
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in duodenum (RPKM 44.2), liver (RPKM 36.4) and 22 other tissues See more
Orthologs
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Genomic context

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See SULT1A1 in Genome Data Viewer
Location:
16p11.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28605258..28623375, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (28772308..28790437)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28616579..28634696, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7310 Neighboring gene SAGA complex associated factor 29 Neighboring gene Sharpr-MPRA regulatory region 4245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28610237-28610771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28610772-28611305 Neighboring gene sulfotransferase family 1A member 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28612139-28612653 Neighboring gene uncharacterized LOC107984835 Neighboring gene uncharacterized LOC124903674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28623750-28624250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28624498-28625048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28625049-28625598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28626587-28627161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7312 Neighboring gene nuclear pore complex interacting protein family member B8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28677654-28678567 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Insights into the substrate binding mechanism of SULT1A1 through molecular dynamics with excited normal modes simulations. Dudas B, et al. Sci Rep, 2021 Jun 23. PMID 34162941, Free PMC Article
  2. Investigating the molecular mechanism of hydroxylated bromdiphenyl ethers to inhibit the thyroid hormone sulfotransferase SULT1A1. Ma G, et al. Chemosphere, 2021 Jan. PMID 33297275
  3. Evaluation of a conserved tryptophanyl residue in donor substrate binding and catalysis by a phenol sulfotransferase (SULT1A1). Beckmann JD, et al. Arch Biochem Biophys, 2020 Nov 30. PMID 33049293
  4. Structural and Dynamic Characterizations Highlight the Deleterious Role of SULT1A1 R213H Polymorphism in Substrate Binding. Dash R, et al. Int J Mol Sci, 2019 Dec 11. PMID 31835852, Free PMC Article
  5. Genetic polymorphisms of 3'-untranslated region of SULT1A1 and their impact on tamoxifen metabolism and efficacy. Sanchez-Spitman AB, et al. Breast Cancer Res Treat, 2018 Nov. PMID 30120701, Free PMC Article

See all (246) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of Conformational Dynamics of Sulfotransferases SULT1A1 and SULT1A3 in Substrate Specificity.
    Title: Role of Conformational Dynamics of Sulfotransferases SULT1A1 and SULT1A3 in Substrate Specificity.
  2. Insights into the substrate binding mechanism of SULT1A1 through molecular dynamics with excited normal modes simulations.
    Title: Insights into the substrate binding mechanism of SULT1A1 through molecular dynamics with excited normal modes simulations.
  3. Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.
    Title: Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.
  4. Prediagnostic circulating inflammation biomarkers and esophageal squamous cell carcinoma: A case-cohort study in Japan.
    Title: Prediagnostic circulating inflammation biomarkers and esophageal squamous cell carcinoma: A case-cohort study in Japan.
  5. Investigating the molecular mechanism of hydroxylated bromdiphenyl ethers to inhibit the thyroid hormone sulfotransferase SULT1A1.
    Title: Investigating the molecular mechanism of hydroxylated bromdiphenyl ethers to inhibit the thyroid hormone sulfotransferase SULT1A1.
  6. Evaluation of a conserved tryptophanyl residue in donor substrate binding and catalysis by a phenol sulfotransferase (SULT1A1).
    Title: Evaluation of a conserved tryptophanyl residue in donor substrate binding and catalysis by a phenol sulfotransferase (SULT1A1).
  7. These findings highlight the key insights of structural consequences caused by R213H mutation, which would enrich the understanding regarding the role of SULT1A1 mutation in cancer development.
    Title: Structural and Dynamic Characterizations Highlight the Deleterious Role of SULT1A1 R213H Polymorphism in Substrate Binding.
  8. Different ethnic and racial populations have varying degrees of SULT1A1-mediated sulfation activity.
    Title: Multi-ethnic SULT1A1 copy number profiling with multiplex ligation-dependent probe amplification.
  9. Patients were categorized in three groups depending on the decreased SULT1A1 activity due to rs6839 and rs1042157: low activity group (rs6839 (GG) and rs1042157 (TT)); high activity group (rs6839 (AA) and rs1042157 (CC)); and medium activity group (all the other combinations of rs6839 and rs1042157). Associations between SULT1A1 phenotypes and clinical outcome (RFS) were explored
    Title: Genetic polymorphisms of 3'-untranslated region of SULT1A1 and their impact on tamoxifen metabolism and efficacy.
  10. Suggest SULT1A1/1A2 play a central role in furfuryl alcohol bioactivation and the formation of hemoglobin adducts.
    Title: Hemoglobin adducts of furfuryl alcohol in genetically modified mouse models: Role of endogenous sulfotransferases 1a1 and 1d1 and transgenic human sulfotransferases 1A1/1A2.
Submit: New GeneRIF Correction See all GeneRIFs (125)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog
Common variants at five new loci associated with early-onset inflammatory bowel disease.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC5163, MGC131921

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables aryl sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aryl sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables flavonol 3-sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables steroid sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amine metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in catecholamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in estrogen metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ethanol catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in flavonoid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sulfation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sulfation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
sulfotransferase 1A1
Names
aryl sulfotransferase 1
phenol-sulfating phenol sulfotransferase 1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
thermostable phenol sulfotransferase1
NP_001046.2
NP_001381350.1
NP_001381351.1
NP_001381352.1
NP_001381353.1
NP_001381354.1
NP_803565.1
NP_803566.1
NP_803878.1
NP_803880.2
XP_016879093.1
XP_016879094.1
XP_016879097.1
XP_016879099.1
XP_047290500.1
XP_047290501.1
XP_047290502.1
XP_047290503.1
XP_047290504.1
XP_047290505.1
XP_047290506.1
XP_054169761.1
XP_054169762.1
XP_054169763.1
XP_054169764.1
XP_054169765.1
XP_054169766.1
XP_054169767.1
XP_054169768.1
XP_054169769.1
XP_054169770.1
XP_054169771.1
XP_054169772.1
XP_054169773.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028128.1 RefSeqGene

    Range
    18502..23288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001055.4 → NP_001046.2  sulfotransferase 1A1 isoform a

    See identical proteins and their annotated locations for NP_001046.2

    Status: REVIEWED

    Source sequence(s)
    AC020765
    Consensus CDS
    CCDS32420.1
    UniProtKB/Swiss-Prot
    P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7
    UniProtKB/TrEMBL
    H3BRY5
    Related
    ENSP00000321988.7, ENST00000314752.12
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 287
    Sulfotransfer_1; Sulfotransferase domain

  2. NM_001394421.1 → NP_001381350.1  sulfotransferase 1A1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC020765
    Consensus CDS
    CCDS32420.1
    UniProtKB/Swiss-Prot
    P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7
    UniProtKB/TrEMBL
    H3BRY5
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 287
    Sulfotransfer_1; Sulfotransferase domain

  3. NM_001394422.1 → NP_001381351.1  sulfotransferase 1A1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC020765
    Consensus CDS
    CCDS32420.1
    UniProtKB/Swiss-Prot
    P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7
    UniProtKB/TrEMBL
    H3BRY5
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 287
    Sulfotransfer_1; Sulfotransferase domain

  4. NM_001394423.1 → NP_001381352.1  sulfotransferase 1A1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC020765
    Consensus CDS
    CCDS32420.1
    UniProtKB/Swiss-Prot
    P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7
    UniProtKB/TrEMBL
    H3BRY5
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 287
    Sulfotransfer_1; Sulfotransferase domain

  5. NM_001394424.1 → NP_001381353.1  sulfotransferase 1A1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC020765
    Consensus CDS
    CCDS32420.1
    UniProtKB/Swiss-Prot
    P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7
    UniProtKB/TrEMBL
    H3BRY5
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 287
    Sulfotransfer_1; Sulfotransferase domain

  6. NM_001394425.1 → NP_001381354.1  sulfotransferase 1A1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC020765
    Consensus CDS
    CCDS32420.1
    UniProtKB/Swiss-Prot
    P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7
    UniProtKB/TrEMBL
    H3BRY5
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 287
    Sulfotransfer_1; Sulfotransferase domain

  7. NM_177529.3 → NP_803565.1  sulfotransferase 1A1 isoform a

    See identical proteins and their annotated locations for NP_803565.1

    Status: REVIEWED

    Source sequence(s)
    AC020765
    Consensus CDS
    CCDS32420.1
    UniProtKB/Swiss-Prot
    P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7
    UniProtKB/TrEMBL
    H3BRY5
    Related
    ENSP00000456459.1, ENST00000566189.5
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 287
    Sulfotransfer_1; Sulfotransferase domain

  8. NM_177530.4 → NP_803566.1  sulfotransferase 1A1 isoform a

    See identical proteins and their annotated locations for NP_803566.1

    Status: REVIEWED

    Source sequence(s)
    AC020765
    Consensus CDS
    CCDS32420.1
    UniProtKB/Swiss-Prot
    P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7
    UniProtKB/TrEMBL
    H3BRY5
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 287
    Sulfotransfer_1; Sulfotransferase domain

  9. NM_177534.4 → NP_803878.1  sulfotransferase 1A1 isoform a

    See identical proteins and their annotated locations for NP_803878.1

    Status: REVIEWED

    Source sequence(s)
    AC020765
    Consensus CDS
    CCDS32420.1
    UniProtKB/Swiss-Prot
    P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7
    UniProtKB/TrEMBL
    H3BRY5
    Related
    ENSP00000457912.1, ENST00000569554.5
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 287
    Sulfotransfer_1; Sulfotransferase domain

  10. NM_177536.5 → NP_803880.2  sulfotransferase 1A1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC020765
    Conserved Domains (1) summary
    cl21551
    Location:24 → 188
    Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    28605258..28623375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434549.1 → XP_047290505.1  sulfotransferase 1A1 isoform X3

  2. XM_047434547.1 → XP_047290503.1  sulfotransferase 1A1 isoform X1

  3. XM_047434544.1 → XP_047290500.1  sulfotransferase 1A1 isoform X1

  4. XM_017023608.2 → XP_016879097.1  sulfotransferase 1A1 isoform X1

    UniProtKB/TrEMBL
    H3BRY5
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 293
    Sulfotransfer_1; Sulfotransferase domain

  5. XM_047434546.1 → XP_047290502.1  sulfotransferase 1A1 isoform X1

  6. XM_047434545.1 → XP_047290501.1  sulfotransferase 1A1 isoform X1

  7. XM_047434548.1 → XP_047290504.1  sulfotransferase 1A1 isoform X2

    UniProtKB/Swiss-Prot
    P50225, Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7

  8. XM_017023610.2 → XP_016879099.1  sulfotransferase 1A1 isoform X1

    UniProtKB/TrEMBL
    H3BRY5
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 293
    Sulfotransfer_1; Sulfotransferase domain

  9. XM_017023605.2 → XP_016879094.1  sulfotransferase 1A1 isoform X1

    UniProtKB/TrEMBL
    H3BRY5
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 293
    Sulfotransfer_1; Sulfotransferase domain

  10. XM_017023604.2 → XP_016879093.1  sulfotransferase 1A1 isoform X1

    UniProtKB/TrEMBL
    H3BRY5
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 293
    Sulfotransfer_1; Sulfotransferase domain

  11. XM_047434550.1 → XP_047290506.1  sulfotransferase 1A1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    28772308..28790437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313786.1 → XP_054169761.1  sulfotransferase 1A1 isoform X5

  2. XM_054313788.1 → XP_054169763.1  sulfotransferase 1A1 isoform X7

  3. XM_054313787.1 → XP_054169762.1  sulfotransferase 1A1 isoform X6

  4. XM_054313789.1 → XP_054169764.1  sulfotransferase 1A1 isoform X8

  5. XM_054313791.1 → XP_054169766.1  sulfotransferase 1A1 isoform X10

  6. XM_054313792.1 → XP_054169767.1  sulfotransferase 1A1 isoform X11

  7. XM_054313794.1 → XP_054169769.1  sulfotransferase 1A1 isoform X1

  8. XM_054313797.1 → XP_054169772.1  sulfotransferase 1A1 isoform X3

  9. XM_054313790.1 → XP_054169765.1  sulfotransferase 1A1 isoform X9

  10. XM_054313798.1 → XP_054169773.1  sulfotransferase 1A1 isoform X1

  11. XM_054313793.1 → XP_054169768.1  sulfotransferase 1A1 isoform X2

  12. XM_054313796.1 → XP_054169771.1  sulfotransferase 1A1 isoform X1

  13. XM_054313795.1 → XP_054169770.1  sulfotransferase 1A1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50225.3 GenPept UniProtKB/Swiss-Prot:P50225

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