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Fdx2 ferredoxin 2 [ Mus musculus (house mouse) ]

Gene ID: 68165, updated on 5-Mar-2024

Summary

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Official Symbol
Fdx2provided by MGI
Official Full Name
ferredoxin 2provided by MGI
Primary source
MGI:MGI:1915415
See related
Ensembl:ENSMUSG00000079677 AllianceGenome:MGI:1915415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fdx1l; B230118G17Rik
Summary
Predicted to enable 2 iron, 2 sulfur cluster binding activity; electron transfer activity; and metal ion binding activity. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial myopathy. Orthologous to human FDX2 (ferredoxin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 38.6), cortex adult (RPKM 27.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A3; 9 7.7 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20978808..20984827, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21067512..21073531, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26592 Neighboring gene intercellular adhesion molecule 5, telencephalin Neighboring gene zinc finger, GATA-like protein 1 Neighboring gene predicted gene, 38431 Neighboring gene ribonucleoprotein, PTB-binding 1 Neighboring gene microRNA 7082 Neighboring gene STARR-positive B cell enhancer ABC_E459 Neighboring gene tyrosine kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E1780

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery. Gakh O, et al. J Biol Chem, 2016 Sep 30. PMID 27519411, Free PMC Article
  2. Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex. Boniecki MT, et al. Nat Commun, 2017 Nov 3. PMID 29097656, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables electron transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in P450-containing electron transport chain IEA
Inferred from Electronic Annotation
more info
  
involved_in [2Fe-2S] cluster assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of [4Fe-4S] cluster assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron-sulfur cluster assembly NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of iron-sulfur cluster assembly complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
ferredoxin-2, mitochondrial
Names
adrenodoxin-like protein, mitochondrial
ferredoxin 1-like
ferredoxin-1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039824.3 → NP_001034913.1  ferredoxin-2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001034913.1

    Status: VALIDATED

    Source sequence(s)
    AK020979, BC061189, BF318146
    Consensus CDS
    CCDS22892.1
    UniProtKB/Swiss-Prot
    Q6P8M0, Q9CPW2, Q9CV00
    Related
    ENSMUSP00000010348.6, ENSMUST00000010348.7
    Conserved Domains (1) summary
    PLN02593
    Location:59 → 174
    PLN02593; adrenodoxin-like ferredoxin protein

RNA

  1. NR_157201.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC061189, BF318146
    Related
    ENSMUST00000217150.2

  2. NR_157202.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163637

  3. NR_157203.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163637

  4. NR_157204.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163637

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    20978808..20984827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPW2.1 GenPept UniProtKB/Swiss-Prot:Q9CPW2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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