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Gtf2e2 general transcription factor II E, polypeptide 2 (beta subunit) [ Mus musculus (house mouse) ]

Gene ID: 68153, updated on 11-Apr-2024

Summary

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Official Symbol
Gtf2e2provided by MGI
Official Full Name
general transcription factor II E, polypeptide 2 (beta subunit)provided by MGI
Primary source
MGI:MGI:1915403
See related
Ensembl:ENSMUSG00000031585 AllianceGenome:MGI:1915403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
34kDa; C330006J08Rik
Summary
Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in transcription initiation from RNA polymerase II promoter. Predicted to be located in cytosol and nuclear speck. Predicted to be part of transcription factor TFIID complex and transcription factor TFIIE complex. Is expressed in several structures, including alimentary system; blastocyst; central nervous system; genitourinary system; and liver lobe. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 6. Orthologous to human GTF2E2 (general transcription factor IIE subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 3.8), placenta adult (RPKM 3.6) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A4; 8 20.79 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (34221942..34267201)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (33731914..33777173)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene glutathione reductase Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene predicted gene, 40485 Neighboring gene RIKEN cDNA 1700104B16 gene Neighboring gene STARR-seq mESC enhancer starr_21117 Neighboring gene small integral membrane protein 18 Neighboring gene RNA binding protein gene with multiple splicing Neighboring gene STARR-seq mESC enhancer starr_21127 Neighboring gene VISTA enhancer mm70 Neighboring gene STARR-seq mESC enhancer starr_21144 Neighboring gene STARR-seq mESC enhancer starr_21145 Neighboring gene predicted gene, 51528 Neighboring gene STARR-seq mESC enhancer starr_21150 Neighboring gene STARR-positive B cell enhancer mm9_chr8:35078702-35079003 Neighboring gene predicted gene, 33588

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A murine ATFa-associated factor with transcriptional repressing activity. De Graeve F, et al. Oncogene, 2000 Mar 30. PMID 10777215
  2. Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation. De Cegli R, et al. Nucleic Acids Res, 2013 Jan. PMID 23180766, Free PMC Article
  3. TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation. Alpern D, et al. Elife, 2014 Sep 10. PMID 25209997, Free PMC Article
  4. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article
  5. Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Kamileri I, et al. Proc Natl Acad Sci U S A, 2012 Feb 21. PMID 22323595, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to TFIIH-class transcription factor complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIE complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
general transcription factor IIE subunit 2
Names
TFIIE-beta
general transcription factor II E, polypeptide 2 (beta subunit, 34kD)
general transcription factor IIE, polypeptide 2 (beta subunit, 34kD)
transcription initiation factor IIE subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167921.1 → NP_001161393.1  general transcription factor IIE subunit 2

    See identical proteins and their annotated locations for NP_001161393.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK146803, AW538417, CX239577, DV042794
    Consensus CDS
    CCDS22236.1
    UniProtKB/Swiss-Prot
    Q3U5Y7, Q8BTZ2, Q8VE14, Q9D902
    UniProtKB/TrEMBL
    Q9CWC4
    Related
    ENSMUSP00000126284.2, ENSMUST00000170705.8
    Conserved Domains (2) summary
    cd07977
    Location:69 → 147
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    pfam18121
    Location:147 → 205
    TFA2_Winged_2; TFA2 Winged helix domain 2

  2. NM_001167922.1 → NP_001161394.1  general transcription factor IIE subunit 2

    See identical proteins and their annotated locations for NP_001161394.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK146803, AW538417, BX516160, DV042794
    Consensus CDS
    CCDS22236.1
    UniProtKB/Swiss-Prot
    Q3U5Y7, Q8BTZ2, Q8VE14, Q9D902
    UniProtKB/TrEMBL
    Q9CWC4
    Related
    ENSMUSP00000132287.2, ENSMUST00000171010.8
    Conserved Domains (2) summary
    cd07977
    Location:69 → 147
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    pfam18121
    Location:147 → 205
    TFA2_Winged_2; TFA2 Winged helix domain 2

  3. NM_026584.3 → NP_080860.3  general transcription factor IIE subunit 2

    See identical proteins and their annotated locations for NP_080860.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK146803, AW538417, BY256665, DV042794
    Consensus CDS
    CCDS22236.1
    UniProtKB/Swiss-Prot
    Q3U5Y7, Q8BTZ2, Q8VE14, Q9D902
    UniProtKB/TrEMBL
    Q9CWC4
    Related
    ENSMUSP00000129834.2, ENSMUST00000167264.8
    Conserved Domains (2) summary
    cd07977
    Location:69 → 147
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    pfam18121
    Location:147 → 205
    TFA2_Winged_2; TFA2 Winged helix domain 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    34221942..34267201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509188.4 → XP_006509251.1  general transcription factor IIE subunit 2 isoform X2

    See identical proteins and their annotated locations for XP_006509251.1

    UniProtKB/Swiss-Prot
    Q3U5Y7, Q8BTZ2, Q8VE14, Q9D902
    UniProtKB/TrEMBL
    Q9CWC4
    Conserved Domains (2) summary
    cd07977
    Location:69 → 147
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    pfam18121
    Location:147 → 205
    TFA2_Winged_2; TFA2 Winged helix domain 2

  2. XM_006509186.3 → XP_006509249.1  general transcription factor IIE subunit 2 isoform X2

    See identical proteins and their annotated locations for XP_006509249.1

    UniProtKB/Swiss-Prot
    Q3U5Y7, Q8BTZ2, Q8VE14, Q9D902
    UniProtKB/TrEMBL
    Q9CWC4
    Conserved Domains (2) summary
    cd07977
    Location:69 → 147
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    pfam18121
    Location:147 → 205
    TFA2_Winged_2; TFA2 Winged helix domain 2

  3. XM_006509187.2 → XP_006509250.1  general transcription factor IIE subunit 2 isoform X2

    See identical proteins and their annotated locations for XP_006509250.1

    UniProtKB/Swiss-Prot
    Q3U5Y7, Q8BTZ2, Q8VE14, Q9D902
    UniProtKB/TrEMBL
    Q9CWC4
    Conserved Domains (2) summary
    cd07977
    Location:69 → 147
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    pfam18121
    Location:147 → 205
    TFA2_Winged_2; TFA2 Winged helix domain 2

  4. XM_036154260.1 → XP_036010153.1  general transcription factor IIE subunit 2 isoform X2

    UniProtKB/Swiss-Prot
    Q3U5Y7, Q8BTZ2, Q8VE14, Q9D902
    UniProtKB/TrEMBL
    Q9CWC4
    Conserved Domains (2) summary
    cd07977
    Location:69 → 147
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    pfam18121
    Location:147 → 205
    TFA2_Winged_2; TFA2 Winged helix domain 2

  5. XM_036154258.1 → XP_036010151.1  general transcription factor IIE subunit 2 isoform X2

    UniProtKB/Swiss-Prot
    Q3U5Y7, Q8BTZ2, Q8VE14, Q9D902
    UniProtKB/TrEMBL
    Q9CWC4
    Conserved Domains (2) summary
    cd07977
    Location:69 → 147
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    pfam18121
    Location:147 → 205
    TFA2_Winged_2; TFA2 Winged helix domain 2

  6. XM_030243746.2 → XP_030099606.1  general transcription factor IIE subunit 2 isoform X2

    UniProtKB/Swiss-Prot
    Q3U5Y7, Q8BTZ2, Q8VE14, Q9D902
    UniProtKB/TrEMBL
    Q9CWC4
    Conserved Domains (2) summary
    cd07977
    Location:69 → 147
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    pfam18121
    Location:147 → 205
    TFA2_Winged_2; TFA2 Winged helix domain 2

  7. XM_006509185.5 → XP_006509248.1  general transcription factor IIE subunit 2 isoform X1

    UniProtKB/TrEMBL
    Q9CWC4
    Conserved Domains (2) summary
    cd07977
    Location:72 → 150
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    pfam18121
    Location:150 → 208
    TFA2_Winged_2; TFA2 Winged helix domain 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D902.2 GenPept UniProtKB/Swiss-Prot:Q9D902

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