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Eif3h eukaryotic translation initiation factor 3, subunit H [ Mus musculus (house mouse) ]

Gene ID: 68135, updated on 11-Apr-2024

Summary

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Official Symbol
Eif3hprovided by MGI
Official Full Name
eukaryotic translation initiation factor 3, subunit Hprovided by MGI
Primary source
MGI:MGI:1915385
See related
Ensembl:ENSMUSG00000022312 AllianceGenome:MGI:1915385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
40kD; Eif3s3; EIF3-P40; EIF3-gamma; 1110008A16Rik; 9430017H16Rik
Summary
Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is expressed in axial skeleton; central nervous system; early conceptus; oocyte; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; prostate cancer; and prostate carcinoma. Orthologous to human EIF3H (eukaryotic translation initiation factor 3 subunit H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 124.1), CNS E14 (RPKM 118.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Eif3h in Genome Data Viewer
Location:
15 C; 15 19.42 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (51649956..51728901, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (51786563..51865461, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38649 Neighboring gene predicted gene, 34503 Neighboring gene STARR-seq mESC enhancer starr_38651 Neighboring gene predicted gene, 41320 Neighboring gene STARR-seq mESC enhancer starr_38653 Neighboring gene STARR-positive B cell enhancer ABC_E4132 Neighboring gene STARR-positive B cell enhancer ABC_E5475 Neighboring gene predicted gene, 34678 Neighboring gene UTP23 small subunit processome component Neighboring gene predicted gene, 48923

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A forward genetic screen identifies eukaryotic translation initiation factor 3, subunit H (eIF3h), as an enhancer of variegation in the mouse. Daxinger L, et al. G3 (Bethesda), 2012 Nov. PMID 23173090, Free PMC Article
  2. Mouse p56 blocks a distinct function of eukaryotic initiation factor 3 in translation initiation. Hui DJ, et al. J Biol Chem, 2005 Feb 4. PMID 15561726
  3. A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice. Fantauzzo KA, et al. Hum Mol Genet, 2008 Nov 15. PMID 18713754, Free PMC Article
  4. Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c. Fujii K, et al. Dev Cell, 2021 Nov 8. PMID 34752747, Free PMC Article
  5. The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. Zeng L, et al. J Biol Chem, 2013 Oct 18. PMID 24003236, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identified of the first two alleles of eIF3h in an unbiased forward genetic screen for modifiers of epigenetic reprogramming in the mouse.
    Title: A forward genetic screen identifies eukaryotic translation initiation factor 3, subunit H (eIF3h), as an enhancer of variegation in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107627

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal-dependent deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 43S preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation initiation factor 3 complex, eIF3m IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit H
Names
eIF3 p40 subunit
eukaryotic translation initiation factor 3 subunit 3
eukaryotic translation initiation factor 3, subunit 3 (gamma)
eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418513.1 → NP_001405442.1  eukaryotic translation initiation factor 3 subunit H isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102229

  2. NM_001418514.1 → NP_001405443.1  eukaryotic translation initiation factor 3 subunit H isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC102229

  3. NM_001418515.1 → NP_001405444.1  eukaryotic translation initiation factor 3 subunit H isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC102229

  4. NM_001418516.1 → NP_001405445.1  eukaryotic translation initiation factor 3 subunit H isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC102229

  5. NM_080635.2 → NP_542366.1  eukaryotic translation initiation factor 3 subunit H isoform 1

    See identical proteins and their annotated locations for NP_542366.1

    Status: VALIDATED

    Source sequence(s)
    AC102229
    Consensus CDS
    CCDS27461.1
    UniProtKB/Swiss-Prot
    Q91WK2
    UniProtKB/TrEMBL
    Q3THW7, Q3TII2, Q5M9L0, Q8BTX5
    Related
    ENSMUSP00000022925.9, ENSMUST00000022925.10
    Conserved Domains (1) summary
    cd08065
    Location:37 → 300
    MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    51649956..51728901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WK2.1 GenPept UniProtKB/Swiss-Prot:Q91WK2

Gene LinkOut

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