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Fahd2a fumarylacetoacetate hydrolase domain containing 2A [ Mus musculus (house mouse) ]

Gene ID: 68126, updated on 21-Apr-2024

Summary

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Official Symbol
Fahd2aprovided by MGI
Official Full Name
fumarylacetoacetate hydrolase domain containing 2Aprovided by MGI
Primary source
MGI:MGI:1915376
See related
Ensembl:ENSMUSG00000027371 AllianceGenome:MGI:1915376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fahd2; Cgi-105; 1500003K14Rik; B430104H02Rik
Summary
Predicted to enable hydro-lyase activity. Located in mitochondrion. Orthologous to several human genes including FAHD2A (fumarylacetoacetate hydrolase domain containing 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 26.8), adrenal adult (RPKM 13.0) and 28 other tissues See more
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Genomic context

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Location:
2 F1; 2 62.01 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (127278135..127286491, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (127436215..127444571, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39923 Neighboring gene STARR-seq mESC enhancer starr_05626 Neighboring gene glycerol-3-phosphate acyltransferase 2, mitochondrial Neighboring gene STARR-positive B cell enhancer mm9_chr2:127279437-127279737 Neighboring gene Kv channel interacting protein 3, calsenilin Neighboring gene predicted gene, 35478 Neighboring gene predicted gene, 54151 Neighboring gene prominin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential expression of murine CGI-105 gene in 3T3-L1 cells by adrenocorticotropic hormones. Choi H, et al. Cell Biol Int, 2005 Feb. PMID 15774318
  2. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CGI-105 mRNA is induced in differentiating 3T3-L1 cells by adrenocorticotropic hormones.
    Title: Differential expression of murine CGI-105 gene in 3T3-L1 cells by adrenocorticotropic hormones.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
fumarylacetoacetate hydrolase domain-containing protein 2A
NP_083905.1
XP_006500153.1
XP_006500154.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029629.2 → NP_083905.1  fumarylacetoacetate hydrolase domain-containing protein 2A

    See identical proteins and their annotated locations for NP_083905.1

    Status: VALIDATED

    Source sequence(s)
    AI841210, AK080868, BY269533
    Consensus CDS
    CCDS16702.1
    UniProtKB/Swiss-Prot
    Q3TC72, Q8K0V8
    UniProtKB/TrEMBL
    A0A0R4J094
    Related
    ENSMUSP00000028848.4, ENSMUST00000028848.4
    Conserved Domains (2) summary
    COG0179
    Location:51 → 313
    MhpD; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism]
    pfam01557
    Location:109 → 312
    FAA_hydrolase; Fumarylacetoacetate (FAA) hydrolase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    127278135..127286491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500090.2 → XP_006500153.1  fumarylacetoacetate hydrolase domain-containing protein 2A isoform X1

    Conserved Domains (1) summary
    COG0179
    Location:27 → 223
    MhpD; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism]

  2. XM_006500091.1 → XP_006500154.1  fumarylacetoacetate hydrolase domain-containing protein 2A isoform X2

    Conserved Domains (1) summary
    pfam01557
    Location:1 → 152
    FAA_hydrolase; Fumarylacetoacetate (FAA) hydrolase family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_026568.1: Suppressed sequence

    Description
    NM_026568.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TC72.1 GenPept UniProtKB/Swiss-Prot:Q3TC72

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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