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Cep70 centrosomal protein 70 [ Mus musculus (house mouse) ]

Gene ID: 68121, updated on 1-Apr-2024

Summary

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Official Symbol
Cep70provided by MGI
Official Full Name
centrosomal protein 70provided by MGI
Primary source
MGI:MGI:1915371
See related
Ensembl:ENSMUSG00000056267 AllianceGenome:MGI:1915371
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bite; 6720484E09Rik; C030018L16Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in cilium assembly and regulation of microtubule cytoskeleton organization. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in centrosome. Orthologous to human CEP70 (centrosomal protein 70). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 3.5), CNS E14 (RPKM 3.3) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 E3.3; 9 51.45 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (99065640..99205569)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (99183584..99325879)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene predicted gene, 33857 Neighboring gene STARR-positive B cell enhancer ABC_E9773 Neighboring gene predicted gene 2950 Neighboring gene STARR-seq mESC enhancer starr_25018 Neighboring gene Fas apoptotic inhibitory molecule like Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 8 pseudogene Neighboring gene RIKEN cDNA 4930422M22 gene Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 14 pseudogene Neighboring gene extended synaptotagmin-like protein 3 Neighboring gene STARR-seq mESC enhancer starr_25024 Neighboring gene muscle and microspikes RAS Neighboring gene predicted gene, 53543 Neighboring gene RIKEN cDNA 1600029I14 gene Neighboring gene NME/NM23 family member 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cep70 contributes to angiogenesis by modulating microtubule rearrangement and stimulating cell polarization and migration. Shi X, et al. Cell Cycle, 2012 Apr 15. PMID 22437770
  2. Loss of CEP70 function affects acrosome biogenesis and flagella formation during spermiogenesis. Liu Q, et al. Cell Death Dis, 2021 May 12. PMID 33980814, Free PMC Article
  3. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
  4. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cep70 is important for Cdc42 and Rac1 activation to promote angiogenesis.
    Title: Cep70 contributes to angiogenesis by modulating microtubule rearrangement and stimulating cell polarization and migration.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables gamma-tubulin binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
centrosomal protein of 70 kDa
Names
p10-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428870.1 → NP_001415799.1  centrosomal protein of 70 kDa isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159899

  2. NM_023873.5 → NP_076362.2  centrosomal protein of 70 kDa isoform 1

    See identical proteins and their annotated locations for NP_076362.2

    Status: VALIDATED

    Source sequence(s)
    AC159899
    Consensus CDS
    CCDS40738.1
    UniProtKB/Swiss-Prot
    Q3V0L8, Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1
    Related
    ENSMUSP00000091312.4, ENSMUST00000093795.10
    Conserved Domains (1) summary
    TIGR02169
    Location:98 → 351
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    99065640..99205569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313546.3 → XP_017169035.1  centrosomal protein of 70 kDa isoform X3

  2. XM_030244539.2 → XP_030100399.1  centrosomal protein of 70 kDa isoform X3

  3. XM_030244541.2 → XP_030100401.1  centrosomal protein of 70 kDa isoform X4

  4. XM_036155222.1 → XP_036011115.1  centrosomal protein of 70 kDa isoform X4

  5. XM_036155221.1 → XP_036011114.1  centrosomal protein of 70 kDa isoform X4

  6. XM_030244540.2 → XP_030100400.1  centrosomal protein of 70 kDa isoform X4

  7. XM_030244537.2 → XP_030100397.1  centrosomal protein of 70 kDa isoform X2

    Conserved Domains (1) summary
    TIGR02169
    Location:57 → 310
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  8. XM_030244536.2 → XP_030100396.1  centrosomal protein of 70 kDa isoform X1

    UniProtKB/Swiss-Prot
    Q3V0L8, Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1
    Conserved Domains (1) summary
    TIGR02169
    Location:98 → 351
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  9. XM_030244534.2 → XP_030100394.1  centrosomal protein of 70 kDa isoform X1

    UniProtKB/Swiss-Prot
    Q3V0L8, Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1
    Conserved Domains (1) summary
    TIGR02169
    Location:98 → 351
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  10. XM_030244535.2 → XP_030100395.1  centrosomal protein of 70 kDa isoform X1

    UniProtKB/Swiss-Prot
    Q3V0L8, Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1
    Conserved Domains (1) summary
    TIGR02169
    Location:98 → 351
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  11. XM_030244533.2 → XP_030100393.1  centrosomal protein of 70 kDa isoform X1

    UniProtKB/Swiss-Prot
    Q3V0L8, Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1
    Conserved Domains (1) summary
    TIGR02169
    Location:98 → 351
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  12. XM_030244538.2 → XP_030100398.1  centrosomal protein of 70 kDa isoform X2

    Conserved Domains (1) summary
    TIGR02169
    Location:57 → 310
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  13. XM_006511393.2 → XP_006511456.1  centrosomal protein of 70 kDa isoform X4

  14. XM_006511391.4 → XP_006511454.1  centrosomal protein of 70 kDa isoform X3

    See identical proteins and their annotated locations for XP_006511454.1

RNA

  1. XR_003947992.2 RNA Sequence

  2. XR_003947993.2 RNA Sequence

  3. XR_003947990.2 RNA Sequence

  4. XR_003947989.2 RNA Sequence

  5. XR_003947988.2 RNA Sequence

  6. XR_004935539.1 RNA Sequence

  7. XR_001779002.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IQY5.1 GenPept UniProtKB/Swiss-Prot:Q6IQY5

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