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Arpc4 actin related protein 2/3 complex, subunit 4 [ Mus musculus (house mouse) ]

Gene ID: 68089, updated on 5-Mar-2024

Summary

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Official Symbol
Arpc4provided by MGI
Official Full Name
actin related protein 2/3 complex, subunit 4provided by MGI
Primary source
MGI:MGI:1915339
See related
Ensembl:ENSMUSG00000079426 AllianceGenome:MGI:1915339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
20kDa; p20-Arc; 5330419I20Rik
Summary
Predicted to enable actin filament binding activity and enzyme binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to protein-macromolecule adaptor activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in several cellular components, including actin cytoskeleton; cell projection; and nucleus. Predicted to be part of Arp2/3 protein complex. Is expressed in dorsal root ganglion. Used to study psoriasis. Orthologous to several human genes including ARPC4-TTLL3 (ARPC4-TTLL3 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 58.0), placenta adult (RPKM 48.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 E3; 6 52.76 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113355074..113367408)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113378113..113390447)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma) pseudogene Neighboring gene transcriptional adaptor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:113327864-113328099 Neighboring gene tubulin tyrosine ligase-like family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1706 Neighboring gene RNA pseudouridylate synthase domain containing 3 Neighboring gene cell death-inducing DFFA-like effector c Neighboring gene predicted gene, 52871

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Active cell migration is critical for steady-state epithelial turnover in the gut. Krndija D, et al. Science, 2019 Aug 16. PMID 31416964
  2. Knockout of the Arp2/3 complex in epidermis causes a psoriasis-like disease hallmarked by hyperactivation of transcription factor Nrf2. van der Kammen R, et al. Development, 2017 Dec 15. PMID 29113991
  3. mTORC1 and mTORC2 Converge on the Arp2/3 Complex to Promote Kras(G12D)-Induced Acinar-to-Ductal Metaplasia and Early Pancreatic Carcinogenesis. Zhao Y, et al. Gastroenterology, 2021 Apr. PMID 33388318
  4. Epithelial colonization by gut dendritic cells promotes their functional diversification. Rivera CA, et al. Immunity, 2022 Jan 11. PMID 34910930, Free PMC Article
  5. Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion. DeMali KA, et al. J Cell Biol, 2002 Dec 9. PMID 12473693, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Arp2/3 protein complex ISO
Inferred from Sequence Orthology
more info
  
part_of Arp2/3 protein complex TAS
Traceable Author Statement
more info
 PubMed 
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
actin-related protein 2/3 complex subunit 4
Names
arp2/3 complex 20 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170485.1 → NP_001163956.1  actin-related protein 2/3 complex subunit 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC155287, AK017993, AK133626
    Consensus CDS
    CCDS51871.1
    UniProtKB/TrEMBL
    E9PWA7
    Related
    ENSMUSP00000131690.2, ENSMUST00000171058.8
    Conserved Domains (1) summary
    cl05433
    Location:2 → 89
    ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)

  2. NM_001170486.1 → NP_001163957.1  actin-related protein 2/3 complex subunit 4 isoform 3

    See identical proteins and their annotated locations for NP_001163957.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC155287, AK017993, AK133626
    Consensus CDS
    CCDS85117.1
    UniProtKB/TrEMBL
    Q3TX55
    Related
    ENSMUSP00000145344.2, ENSMUST00000203578.3
    Conserved Domains (1) summary
    cl05433
    Location:1 → 76
    ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)

  3. NM_026552.3 → NP_080828.1  actin-related protein 2/3 complex subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_080828.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC155287, AK017993, AK133626
    Consensus CDS
    CCDS20417.1
    UniProtKB/Swiss-Prot
    P59999, Q3UWV4
    UniProtKB/TrEMBL
    Q9D3C4
    Related
    ENSMUSP00000114839.2, ENSMUST00000156898.5
    Conserved Domains (1) summary
    pfam05856
    Location:1 → 166
    ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    113355074..113367408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59999.3 GenPept UniProtKB/Swiss-Prot:P59999

Gene LinkOut

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