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Dmac2l distal membrane arm assembly component 2 like [ Mus musculus (house mouse) ]

Gene ID: 68055, updated on 21-Apr-2024

Summary

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Official Symbol
Dmac2lprovided by MGI
Official Full Name
distal membrane arm assembly component 2 likeprovided by MGI
Primary source
MGI:MGI:1915305
See related
Ensembl:ENSMUSG00000054894 AllianceGenome:MGI:1915305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ATPW; Atp5s; 1110015E18Rik
Summary
Predicted to enable metal ion binding activity. Predicted to act upstream of or within ATP biosynthetic process and ion transport. Located in mitochondrion. Is expressed in several structures, including brain; gallbladder; genitourinary system; gut; and respiratory system. Orthologous to human DMAC2L (distal membrane arm assembly component 2 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 6.3), bladder adult (RPKM 3.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 C2; 12 28.94 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69771687..69791439)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69724913..69744665)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene SOS Ras/Rho guanine nucleotide exchange factor 2 Neighboring gene chloride intracellular channel protein 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32374 Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene STARR-positive B cell enhancer ABC_E2387 Neighboring gene STARR-positive B cell enhancer mm9_chr12:70834549-70834850 Neighboring gene VISTA enhancer mm122 Neighboring gene cyclin dependent kinase like 1 Neighboring gene RIKEN cDNA 4930512B01 gene Neighboring gene microRNA 681 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 5 Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evidence for the involvement of coupling factor B in the H+ channel of the mitochondrial H+-ATPase. Sanadi DR, et al. Proc Natl Acad Sci U S A, 1984 Mar. PMID 6143319, Free PMC Article
  2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP synthase subunit s, mitochondrial
Names
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit S
ATP synthase-coupling factor B
distal membrane arm assembly complex 2 like
distal membrane arm assembly complex 2-like protein
mitochondrial ATP synthase regulatory component factor B
NP_001348619.1
NP_001348620.1
NP_080812.1
XP_006516243.1
XP_006516244.1
XP_011242464.1
XP_011242465.1
XP_011242466.1
XP_030102747.1
XP_030102748.1
XP_030102749.1
XP_036013491.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361690.1 → NP_001348619.1  ATP synthase subunit s, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AI844080, AK003725, AK009141, BB869492
    Consensus CDS
    CCDS25954.1
    UniProtKB/Swiss-Prot
    Q8R2M3, Q9CRA7
    Related
    ENSMUSP00000152430.2, ENSMUST00000220916.2
    Conserved Domains (2) summary
    cd09293
    Location:97 → 166
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:111 → 139
    LRR_AMN1; leucine-rich repeat [structural motif]

  2. NM_001361691.1 → NP_001348620.1  ATP synthase subunit s, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC141560
    Consensus CDS
    CCDS25954.1
    UniProtKB/Swiss-Prot
    Q8R2M3, Q9CRA7
    Conserved Domains (2) summary
    cd09293
    Location:97 → 166
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:111 → 139
    LRR_AMN1; leucine-rich repeat [structural motif]

  3. NM_026536.2 → NP_080812.1  ATP synthase subunit s, mitochondrial precursor

    See identical proteins and their annotated locations for NP_080812.1

    Status: VALIDATED

    Source sequence(s)
    AI844080, AK003725, BB869492
    Consensus CDS
    CCDS25954.1
    UniProtKB/Swiss-Prot
    Q8R2M3, Q9CRA7
    Related
    ENSMUSP00000021372.6, ENSMUST00000021372.6
    Conserved Domains (2) summary
    cd09293
    Location:97 → 166
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:111 → 139
    LRR_AMN1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    69771687..69791439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516180.4 → XP_006516243.1  ATP synthase subunit s, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006516243.1

    Conserved Domains (1) summary
    cd09293
    Location:97 → 159
    AMN1; Antagonist of mitotic exit network protein 1

  2. XM_011244162.3 → XP_011242464.1  ATP synthase subunit s, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011242464.1

    Conserved Domains (1) summary
    cd09293
    Location:97 → 159
    AMN1; Antagonist of mitotic exit network protein 1

  3. XM_030246887.2 → XP_030102747.1  ATP synthase subunit s, mitochondrial isoform X1

    Conserved Domains (1) summary
    cd09293
    Location:97 → 159
    AMN1; Antagonist of mitotic exit network protein 1

  4. XM_030246888.2 → XP_030102748.1  ATP synthase subunit s, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q8R2M3, Q9CRA7
    Conserved Domains (2) summary
    cd09293
    Location:97 → 166
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:111 → 139
    LRR_AMN1; leucine-rich repeat [structural motif]

  5. XM_006516181.4 → XP_006516244.1  ATP synthase subunit s, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006516244.1

    Conserved Domains (1) summary
    cd09293
    Location:97 → 159
    AMN1; Antagonist of mitotic exit network protein 1

  6. XM_036157598.1 → XP_036013491.1  ATP synthase subunit s, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A1Y7VK84
    Related
    ENSMUSP00000152757.2, ENSMUST00000220460.2
    Conserved Domains (1) summary
    cd09293
    Location:97 → 159
    AMN1; Antagonist of mitotic exit network protein 1

  7. XM_011244164.4 → XP_011242466.1  ATP synthase subunit s, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011242466.1

    Conserved Domains (1) summary
    cd09293
    Location:97 → 159
    AMN1; Antagonist of mitotic exit network protein 1

  8. XM_011244163.4 → XP_011242465.1  ATP synthase subunit s, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011242465.1

    Conserved Domains (1) summary
    cd09293
    Location:97 → 159
    AMN1; Antagonist of mitotic exit network protein 1

  9. XM_030246889.2 → XP_030102749.1  ATP synthase subunit s, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q8R2M3, Q9CRA7
    Conserved Domains (2) summary
    cd09293
    Location:97 → 166
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:111 → 139
    LRR_AMN1; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CRA7.1 GenPept UniProtKB/Swiss-Prot:Q9CRA7

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