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Ubxn2b UBX domain protein 2B [ Mus musculus (house mouse) ]

Gene ID: 68053, updated on 11-Apr-2024

Summary

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Official Symbol
Ubxn2bprovided by MGI
Official Full Name
UBX domain protein 2Bprovided by MGI
Primary source
MGI:MGI:1915303
See related
Ensembl:ENSMUSG00000028243 AllianceGenome:MGI:1915303
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p37; 3110003A22Rik; 6430407D20Rik
Summary
Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including establishment of mitotic spindle orientation; negative regulation of protein localization to centrosome; and positive regulation of mitotic centrosome separation. Located in spindle pole centrosome. Orthologous to human UBXN2B (UBX domain protein 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 5.9), CNS E18 (RPKM 5.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A1; 4 2.91 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (6191105..6219788)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (6191105..6219788)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 46 pseudogene Neighboring gene Ras suppressor protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09476 Neighboring gene STARR-positive B cell enhancer ABC_E3480 Neighboring gene Cyp7a1 promoter Neighboring gene STARR-seq mESC enhancer starr_09478 Neighboring gene STARR-seq mESC enhancer starr_09479 Neighboring gene cytochrome P450, family 7, subfamily a, polypeptide 1 Neighboring gene RIKEN cDNA 4930430E12 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. Borodovsky A, et al. EMBO J, 2001 Sep 17. PMID 11566882, Free PMC Article
  2. Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly. van den Boom J, et al. Nat Struct Mol Biol, 2021 Dec. PMID 34824462
  3. p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis. Uchiyama K, et al. Dev Cell, 2006 Dec. PMID 17141156
  4. The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A. Kress E, et al. J Cell Biol, 2013 May 13. PMID 23649807, Free PMC Article
  5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear membrane reassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitotic centrosome separation ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole centrosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
UBX domain-containing protein 2B
Names
NSFL1 cofactor p37
p97 cofactor p37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026534.2 → NP_080810.2  UBX domain-containing protein 2B

    See identical proteins and their annotated locations for NP_080810.2

    Status: VALIDATED

    Source sequence(s)
    BC076632, BY745604
    Consensus CDS
    CCDS17949.1
    UniProtKB/Swiss-Prot
    Q0KL01, Q8BGY8, Q8CCQ0, Q9CZA8
    Related
    ENSMUSP00000029907.6, ENSMUST00000029907.6
    Conserved Domains (2) summary
    cd01770
    Location:255 → 331
    p47_UBX; p47-like ubiquitin domain
    smart00553
    Location:140 → 232
    SEP; Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    6191105..6219788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0KL01.2 GenPept UniProtKB/Swiss-Prot:Q0KL01

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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