U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Chid1 chitinase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 68038, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Chid1provided by MGI
Official Full Name
chitinase domain containing 1provided by MGI
Primary source
MGI:MGI:1915288
See related
Ensembl:ENSMUSG00000025512 AllianceGenome:MGI:1915288
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3110023E09Rik
Summary
Predicted to enable oligosaccharide binding activity. Predicted to be involved in negative regulation of cytokine production involved in inflammatory response. Predicted to act upstream of or within innate immune response. Predicted to be located in several cellular components, including late endosome; lysosome; and trans-Golgi network. Predicted to be active in extracellular region. Orthologous to human CHID1 (chitinase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 13.0), placenta adult (RPKM 12.1) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7 F5; 7 86.86 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141073049..141119818, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141493136..141539905, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10575 Neighboring gene STARR-positive B cell enhancer ABC_E11377 Neighboring gene CD151 antigen Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L Neighboring gene tetraspanin 4 Neighboring gene STARR-seq mESC enhancer starr_20492 Neighboring gene STARR-seq mESC enhancer starr_20493 Neighboring gene adaptor-related protein complex 2, alpha 2 subunit Neighboring gene STARR-positive B cell enhancer ABC_E2855 Neighboring gene predicted gene, 16982 Neighboring gene microRNA 7063

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables oligosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oligosaccharide binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
chitinase domain-containing protein 1
NP_001136153.2
NP_001356279.1
NP_001356280.1
NP_001356281.1
NP_080798.3
XP_006536294.1
XP_011248152.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142681.2 → NP_001136153.2  chitinase domain-containing protein 1 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AK050655, BC006876, BE953974, BY101128
    Consensus CDS
    CCDS52447.2
    UniProtKB/Swiss-Prot
    Q3TVF7, Q6P8U4, Q8C7C5, Q922Q9, Q9CXR7
    UniProtKB/TrEMBL
    A0A0R4J242
    Related
    ENSMUSP00000114693.2, ENSMUST00000153191.8
    Conserved Domains (1) summary
    cd02876
    Location:77 → 393
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...

  2. NM_001369350.1 → NP_001356279.1  chitinase domain-containing protein 1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC158224
    UniProtKB/TrEMBL
    A0A0R4J242
    Conserved Domains (1) summary
    cd02876
    Location:77 → 359
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...

  3. NM_001369351.1 → NP_001356280.1  chitinase domain-containing protein 1 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. It encodes the longest isoform (1). Variants 1, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AC158224
    Consensus CDS
    CCDS52447.2
    UniProtKB/Swiss-Prot
    Q3TVF7, Q6P8U4, Q8C7C5, Q922Q9, Q9CXR7
    UniProtKB/TrEMBL
    A0A0R4J242
    Conserved Domains (1) summary
    cd02876
    Location:77 → 393
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...

  4. NM_001369352.1 → NP_001356281.1  chitinase domain-containing protein 1 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AC158224
    Consensus CDS
    CCDS52447.2
    UniProtKB/Swiss-Prot
    Q3TVF7, Q6P8U4, Q8C7C5, Q922Q9, Q9CXR7
    UniProtKB/TrEMBL
    A0A0R4J242
    Conserved Domains (1) summary
    cd02876
    Location:77 → 393
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...

  5. NM_026522.6 → NP_080798.3  chitinase domain-containing protein 1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the central coding region, compared to variant 1. The resulting isoform (2) has the same N- and C-termini but lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC158224, AK050655, BE953974, BY101128
    Consensus CDS
    CCDS22019.2
    UniProtKB/TrEMBL
    A0A0R4J058
    Related
    ENSMUSP00000112891.2, ENSMUST00000118694.8
    Conserved Domains (1) summary
    cd02876
    Location:77 → 307
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141073049..141119818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249850.4 → XP_011248152.1  chitinase domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    D3YWG2
    Related
    ENSMUSP00000115174.2, ENSMUST00000143561.2
    Conserved Domains (1) summary
    cd02876
    Location:80 → 322
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...

  2. XM_006536231.4 → XP_006536294.1  chitinase domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006536294.1

    UniProtKB/TrEMBL
    A0A0R4J242
    Conserved Domains (1) summary
    cd02876
    Location:80 → 323
    GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922Q9.1 GenPept UniProtKB/Swiss-Prot:Q922Q9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous