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H2bc4 H2B clustered histone 4 [ Mus musculus (house mouse) ]

Gene ID: 68024, updated on 8-Feb-2024

Summary

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Official Symbol
H2bc4provided by MGI
Official Full Name
H2B clustered histone 4provided by MGI
Primary source
MGI:MGI:1915274
See related
Ensembl:ENSMUSG00000018102 AllianceGenome:MGI:1915274
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H2bc6; H2bc8; H2bfs; Hist1h2bc; 2610022J01Rik
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in colon adult (RPKM 339.7), small intestine adult (RPKM 307.1) and 28 other tissues See more
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Genomic context

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See H2bc4 in Genome Data Viewer
Location:
13 A3.1; 13 9.87 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (23868182..23876805)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23684199..23692480)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33968 Neighboring gene predicted gene, 22452 Neighboring gene STARR-positive B cell enhancer ABC_E384 Neighboring gene STARR-positive B cell enhancer ABC_E8514 Neighboring gene H2A clustered histone 6 Neighboring gene H1.6 linker histone, cluster member Neighboring gene H4 clustered histone 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Histone modifications associated with somatic hypermutation. Odegard VH, et al. Immunity, 2005 Jul. PMID 16039583
  2. Phosphorylation of histone H2B at DNA double-strand breaks. Fernandez-Capetillo O, et al. J Exp Med, 2004 Jun 21. PMID 15197225, Free PMC Article
  3. Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro. Ingram DA, et al. J Exp Med, 2001 Jul 2. PMID 11435472, Free PMC Article
  4. Histone H2B as a functionally important plasminogen receptor on macrophages. Das R, et al. Blood, 2007 Nov 15. PMID 17690254, Free PMC Article
  5. Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss. Scekic-Zahirovic J, et al. EMBO J, 2016 May 17. PMID 26951610, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histone H2B type 1-C/E/G
Names
H2B histone family, member S
histone 1, H2bc
histone cluster 1, H2bc

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290380.1 → NP_001277309.1  histone H2B type 1-C/E/G

    See identical proteins and their annotated locations for NP_001277309.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is intronless and differs from variant 1 in its 3' UTR which contains a palindromic termination sequence. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL592149
    Consensus CDS
    CCDS26357.1
    UniProtKB/Swiss-Prot
    Q6ZWY9
    UniProtKB/TrEMBL
    A0JLV3
    Conserved Domains (1) summary
    smart00427
    Location:28 → 124
    H2B; Histone H2B

  2. NM_023422.3 → NP_075911.2  histone H2B type 1-C/E/G

    See identical proteins and their annotated locations for NP_075911.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer, two exon transcript and contains a polyA signal and site. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK011516
    Consensus CDS
    CCDS26357.1
    UniProtKB/Swiss-Prot
    Q6ZWY9
    UniProtKB/TrEMBL
    A0JLV3
    Related
    ENSMUSP00000018246.5, ENSMUST00000018246.6
    Conserved Domains (1) summary
    smart00427
    Location:28 → 124
    H2B; Histone H2B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    23868182..23876805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004938062.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZWY9.3 GenPept UniProtKB/Swiss-Prot:Q6ZWY9

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