Pdf peptide deformylase (mitochondrial) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdfprovided by MGI
Official Full Name: peptide deformylase (mitochondrial)provided by MGI
Primary source: MGI:MGI:1915273
See related: Ensembl:ENSMUSG00000078931 AllianceGenome:MGI:1915273
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2610019N19Rik
Summary: Predicted to enable peptide deformylase activity. Predicted to be involved in cellular protein modification process and positive regulation of cell population proliferation. Predicted to be active in mitochondrion. Orthologous to human PDF (peptide deformylase, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 65.3), ovary adult (RPKM 44.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.55 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (107772921..107775246, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (107046289..107048614, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide deformylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide deformylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-terminal protein amino acid modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-terminal protein amino acid modification	ISO Inferred from Sequence Orthology more info
involved_in co-translational protein modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-methionine modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-methionine modification	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptide deformylase, mitochondrial

Names: peptide deformylase-like protein; polypeptide deformylase

NP_080789.2

EC 3.5.1.88

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026513.2 → NP_080789.2 peptide deformylase, mitochondrial

Status: VALIDATED

Source sequence(s)

AI447856, AK008820, AV099506, BB658019

Consensus CDS

CCDS59743.1

UniProtKB/Swiss-Prot

S4R2K0

Related

ENSMUSP00000138676.2, ENSMUST00000055316.10

Conserved Domains (1) summary

cd00487
Location:55 → 212

Pep_deformylase; Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II) ...