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Cfap298 cilia and flagella associate protien 298 [ Mus musculus (house mouse) ]

Gene ID: 68001, updated on 5-Mar-2024

Summary

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Official Symbol
Cfap298provided by MGI
Official Full Name
cilia and flagella associate protien 298provided by MGI
Primary source
MGI:MGI:1915251
See related
Ensembl:ENSMUSG00000022972 AllianceGenome:MGI:1915251
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110004E09Rik
Summary
Predicted to be involved in cilium assembly and regulation of cilium movement. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 26. Orthologous to human CFAP298 (cilia and flagella associated protein 298). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 38.1), CNS E11.5 (RPKM 13.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C3.3; 16 52.17 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (90721178..90731737, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (90925811..90934849, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41464 Neighboring gene URB1 ribosome biogenesis 1 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E1929 Neighboring gene eva-1 homolog C Neighboring gene predicted gene, 36363 Neighboring gene STARR-seq mESC enhancer starr_41466 Neighboring gene STARR-seq mESC enhancer starr_41467 Neighboring gene STARR-seq mESC enhancer starr_41468 Neighboring gene predicted gene, 53919 Neighboring gene STARR-positive B cell enhancer ABC_E4188 Neighboring gene synaptojanin 1 Neighboring gene RIKEN cDNA 4930404I05 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:91012148-91012449 Neighboring gene STARR-seq mESC enhancer starr_41471 Neighboring gene PAX3 and PAX7 binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
  2. Human chromosome 21 gene expression atlas in the mouse. Reymond A, et al. Nature, 2002 Dec 5. PMID 12466854
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cilium movement ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cilia- and flagella-associated protein 298
Names
UPF0769 protein C21orf59 homolog
protein kurly homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026502.2 → NP_080778.2  cilia- and flagella-associated protein 298

    See identical proteins and their annotated locations for NP_080778.2

    Status: VALIDATED

    Source sequence(s)
    AK045905, CX236612
    Consensus CDS
    CCDS28321.1
    UniProtKB/Swiss-Prot
    Q8BL95, Q8VCL7
    UniProtKB/TrEMBL
    Q9CU27
    Related
    ENSMUSP00000023694.4, ENSMUST00000023694.11
    Conserved Domains (1) summary
    pfam11069
    Location:189 → 285
    DUF2870; Protein of unknown function (DUF2870)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    90721178..90731737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160103.1 → XP_036015996.1  cilia- and flagella-associated protein 298 isoform X1

    UniProtKB/TrEMBL
    Q9CU27
    Conserved Domains (1) summary
    pfam11069
    Location:145 → 239
    DUF2870; Protein of unknown function (DUF2870)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BL95.1 GenPept UniProtKB/Swiss-Prot:Q8BL95

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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